Mohammad Athar, Ph.D.
Mohammad Athar, Ph.D.
University of Alabama at Birmingham
1530 3RD AVE S
BIRMINGHAM AL 35294-0019
B.Sc. 1975. Chemistry. Lucknow University, Lucknow, India.
M.Sc. 1977. Inorganic Chemistry. Lucknow University, Lucknow, India.
M. Phil. 1978. Coordination Chemistry. Aligarh Muslim University, Aligarh, India.
Ph.D. 1980. Coordination Chemistry. Aligarh Muslim University, Aligarh, India.
|Professor and Vice-Chair for Basic Research:||Department of Dermatology|
|Senior Scientist:||UAB Comprehensive Cancer Center|
|Co-Director:||UAB Skin Disease Research Center|
|Faculty Member:||Graduate Schoo, University of Alabama at Birmingham|
|Adjunct Senior Research Scientist:||Columbia University College of Physicians and Surgeons, NY|
Athar M, Khan WA, Mukhtar H. Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicty in Sencar mice. Cancer Res., 1989; 49:5784-5788
Athar M, Elmets CA, Bickers DR, Mukhtar H. A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative-mediated cutaneous photosensitization. Activation of the xanthine oxidative pathway. J. Clin. Invest., 1989; 83:1137-1143.
Krutmann J, Athar M, Mendel DB, Khan IU, Guyre PM, Mukhtar H, Elmets CA. Inhibition of the high affinity Fc receptor (Fc gamma RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals. J. Biol. Chem., 1989; 264:11407-11413.
Athar M, Lloyd JR, Bicers DR, Mukhtar H. Malignant conversion of radiation and chemically-induced mouse skin benign tumors by free radical generating compounts. Carcinogenesis, 1989; 10:1841-1845.
Athar M, Mukhtar H, Bickers DR, Kahn IU, Kalyanaraman B. Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study. Carcinogenesis, 1989; 10:1499-1503.
Anderson AHR, Robbins R, Hasan R, Athar M, Mukhtar H, Elmets CA. Metabolic requirements for induction of contact hypersensitivity to immunotoxic polyaromatic hydrocarcarbons. J. Immunol., 1995; 155: 3530-3537.
Athar M, Iqbal M, Giri U. Novel copper-superoxide dismutase mimics and O2- -mediated damage. Nutrition. 1995; 11:559-63.
Giri U, Iqbal M, Athar M. Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: Possible role of in situ generated reactive oxygen species. Carcinogenesis, 1996; 17:2023-28.
Athar M, Iqbal M. Ferric nitrilotriacetate promotes N-diethylnitrosamine-induced renal tumorigenesis in the rat: implications for the involvement of oxidative stress. Carcinogenesis, 1998; 19:1133-39.
Elmets CA, Athar M, Tubesing KA, Rothaupt D, Xu H, Mukhtar H. Susceptibility to the biological effects of polyaromatic hyrdrocarbons is influenced by genes of the major histocompatibility complex. Proc Natl Acad Sci USA 1998; 95:14915-19.
Ansar S, Iqbal M, Athar M. Nordihydroguairetic acid is a potent inhibitor of ferric-nitrilotriacetate-mediated hepatic and renal toxicity, and renal tumour promotion in mice. Carcinogenesis, 1999: 20:599-606.
Sah NK, Taneja TK, Pathak N, Begum R, Athar M, Hasnain SE. The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway. Proc Natl Acad Sci USA, 1999; 96:4838-43.
Liu SX, Athar M, Lippai I, Waldren C, Hei TK. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci USA, 2001; 98:1643-48.
Trikha P, Sharma N, Athar M. Nitroglycerin: a NO donor inhibits TPA-mediated tumor promotion in murine skin. Carcinogenesis, 2001: 22:1207-1211.
Tang X, Kim AL, Feith DJ, Pegg AE, Russo J, Zhang H, Aszterbaum M, Kopelovich L, Epstein Jr. EH, Bickers DR, Athar M. Ornithine Decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptc1+/- mice. J Clin Invest,2004; 113(6):867-75.
Vogt A, Chuang PT, Herbert J, Hwang J, Lu Y, Kopelovich L., Athar M, Bickers DR, Epstein EH, Jr. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. J Exp Med, 2004; 199:743-52.
Vogt A, Chuang PT, Herbert J, Hwang J, Lu Y, Kopelovich L, Athar M, Bickers DR, Epstein Jr EH. Topical tazarotene reduces basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet radiation or ionizing radiation. Cancer Res, 2004; 64: 4385-89.
Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, Tyring SK, Kopelovich L, Hebert J, Epstein Jr EJ, Bickers DR, Xie J. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomaa through regulation of Fas expression and apoptosis. Cancer Res. 2004; 64: 7545-52.
Liu S, Davidson MM, Tang X, Athar M, Ivanov V, Hei TK. Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Res, 2005; 65(8): 3236-42.
Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin diseases. J Invest Dermatol., 2006; 126:2565-75.
Lebedeva IV, Sarkar D, Su ZZ., Gopalkrishnan RV., Athar M, Randolph A, Valerie K, Dent P, and Fisher PB. Molecular target-based therapy of pancreatic cancer. Cancer Res., 2006; 66:2403-2413.
Arif E, Vibhuti A, Alam P, Deepak D, Singh B, Athar M, Pasha MA. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Clin. Chim. Acta., 2007; 382: 37-42.
Tang X, Zhu Y, Han AL, Kim L, Kopelovich L, Bickers DR, Athar M. CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J. Clin. Invest., 2007; 117:3753-3764.
Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL. Resveratrol: A review of preclinical studies for human cancer prevention. Toxicol. Appl. Pharmacol., 2007; 224: 274-283.
Lebedeva I, Su Z, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB. Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. Mol. Cancer. Therapy, 2008; 7:2042-50.
Lebedeva I, Su Z, Vozhilla N, Chatman L, Sarkar D, Athar M, Fisher PB. Mechanism of in vitro pancreatic cancer cell growth inhibition by mda-7/IL-24 and perillyl alcohol. Cancer Res., 2008; 68:7439-47.
Pradhan S, Kim HK, Thrash CJ, Cox MA, Mantena SK, Wu JH, Athar M, Katiyar SK, Elmets CA, Timares L. A critical role for the proapoptotic protein Bid in UV-induced immune suppression and cutaneous apoptosis. J Immunol., 2008; 181: 3077-88.
Hsieh Y-C, Athar M, Chaudry IH. When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol. Med., 2009; 15: 129-38.
Shaik SS, Soltau TD, Chaturvedi G, Totapally B, Hagood JS, Andrews WW, Athar M, Killingsworth C, Patel RP, Fallon MB, Maheshwari A. Low intensity shear stress increases endothelial ELR CXC chemokine production via a FAK-p38B-NF-KB pathway. J. Biol. Chem., 2009; 284:5945-55.
Tang JY, Aszterbaum M, Athar M, Barsanti F, Cappola C, Estevez N, Hebert J, Hwang J, Khaimskiy Y, Kim AL, Lu Y, So PL, Tang X, Kohn MA, McCulloch CE, Kopelovich L, Bickers DR, Epstein Jr. EH. Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and mice. Cancer Prev. Res. (Phil, PA), 2010; 3: 25-34.
Elmets CA, Athar M. Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans. Cancer Prev. Res. (Phil, PA), 2010; 3: 8-11.
Xu J, Timares L, Heilpern C, Weng Z, Li C, Xu H, Pressey JG, Elmets CA, Kopelovich L, Athar M. Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. Cancer Res., 2010; 70: 6566-76.
Kim KH, Back JH, Zhu Y, Arbesman J, Athar M, Kopelovich L, Kim AL, Bickers DR. Resveratrol targets transforming growth factor-beta2 signaling to block UV-induced tumor progression. J Invest. Dermatol., 2011; 131: 195-202.
Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, Athar M, Shimamura M, Bhandari V, Aprahamian C, Dimmitt RA, Serra R, Ohis RK. TGF-Beta(2) suppresses cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology, 2011; 140: 242-53.
Active Grant Support
Project entilted "Inhibiting multiple molecular targets for preventing non-melanoma skin cancer
Principle Investigator: Mohammad Athar, Ph.D.
Period: 03/04/2011 - 02/28/2016
Project entitled "Role of p53 and ptc tumor suppressive pathways in BCCs development and prevention"
Period: 9/30/2006 - 5/31/2012
Project entitled "Effects of chemopreventive agents on the development of basal cell and squamous cell carcinomas in Ptc-/+ heterozygous hairless murine model"
Period: 12/01/2007 - 04/30/11
Project entitled "Developing a murine model for arsenic-induced skin neoplasml"
Period: 7/1/2009 - 6/30/2012