Douglas R. Moellering, PhD

Moellering-DougInstructor

Dept. of Nutrition Sciences

School of Health Professions

Contact Information

Office Address: VH G004
Phone: 205-996-2660
E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.
Websites: Dept. of Nutrition Sciences Faculty Page

Education:

Thomas More College, Crestview Hills, KY

BA, Biology, 1991


University of Alabama at Birmingham

MS, Basic Medical Sciences (Physiology & Biophysics), 1995

University of Alabama at Birmingham

PhD, Cellular and Molecular Pathology, 2003

Post-Graduate Training:

University of Alabama at Birmingham
Postdoctoral Fellow, Department of Nutrition Sciences, 2003-8

Research Interest

Dr. Moellering is an Instructor of Nutrition Sciences, a Scientist in the Diabetes Research Center (DRC), and Manger of the DRC's Redox Biology Core (BARB).  He developed and manages the Redox Core serving multiple investigators in measuring functional mitochondrial physiology, bioenergetics, enzyme activity, markers of oxidative stress, and/or reactive oxygen species formation.   Eighty percent of the air we breathe and most of the food that is consumed and absorbed are metabolized within mitochondria to produce 90% of the energy, in the form of ATP, necessary for use in all cellular processes, including exercise, growth, and reproduction.  

Dr. Moellering's studies support accumulating evidence that many diseases involve mitochondrial dysfunction with concomitant increased reactive oxygen and/or nitrogen species formation.  Some of these diseases include insulin resistance, Type 2 Diabetes Mellitus (T2DM), Parkinson's disease, Alzheimer's disease, cardiovascular disease, atherosclerosis, cancer, obesity, and Harman’s free-radical theory of aging (although aging is not a disease). These reactive products are called free radicals since they contain one or more unpaired electrons. Free radical-mediated alterations in energy production, tissue injury, and human disease are pervasive, and still poorly understood.  

Dr. Moellering's research interests involve mitochondrial physiology, bioenergetics, and free radical-mediated tissue injury and disease pathologies.  Currently his research is focused on mitochondrial free-radical production contributing to altered bioenergetics, the development of obesity, insulin resistance and T2DM, increased cardiovascular disease susceptibility, and aging.

Publications

DRC Membership Category:

Scientist