Fadi G. Hage, MD

Fadi-HageAssistant Professor

Dept. of Medicine

Division of Cardiovascular Disease


Contact Information

Office Address: ZRB 1022
Phone: 205-934-0406
E-mail: fadihage@uab.edu
Websites: Faculty Profile


Education:

Saint Mary Orthodox College, Beirut, Lebanon
1994 Lebanese Baccalaureate II with honors


American University of Beirut, Beirut, Lebanon
1997 BS Chemistry with Distinction

2001 MD with Distinction


Post-Graduate Training:

Intern in Medicine, American University of Beirut, Beirut, Lebanon

Intern in Medicine, University of Alabama at Birmingham

Resident in Medicine, University of Alabama at Birmingham

Fellowship in Cardiovascular Disease, University of Alabama at Birmingham

Postdoctoral training in Vascular Biology and Hypertension, University of Alabama at Birmingham

Frommeyer Fellowship in Investigative Medicine, University of Alabama at Birmingham


Research Interests:

Vascular injury, inflammation and cardiovascular imaging


Research Description:

Dr Hage is a cardiologist with research interest in vascular injury, inflammation and cardiovascular imaging. Since the introduction of high-sensitivity assays for C-reactive protein (CRP), vast amounts of clinical data suggests that serum CRP levels can predict risk of cardiovascular disease but no clinical study has established a direct cause-and-effect relationship between CRP and vascular injury. Using a CRP transgenic mouse he has shown that CRP facilitates the adverse remodeling seen after acute arterial injury and that this depends on expression of the activating immunoglobulin receptor FcgRI and its accessory common g-chain and on a functioning complement system. If these findings are confirmed in humans they could have important therapeutic implications.

In addition, Dr Hage is interested in investigating the high cardiovascular risk of patients with chronic kidney disease.  By studying the survival of almost four thousand patients with end-stage renal disease evaluated for renal transplantation at UAB he has shown that a depressed left ventricular function is the strongest predictor of mortality in this population. Coronary revascularization had a limited impact on survival and myocardial perfusion imaging provided more powerful prognostic information than coronary anatomy by angiography. He is currently pursuing several novel predictors of risk in chronic kidney disease including markers of sudden cardiac death.

Publications


DRC Membership Category:

Scientist