Jack R. Lancaster, PhD

Professor

Dept. of Anesthesiology

Contact Information:

Office Address: BMR2 222
Phone: 2005-975-9673
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Websites: Dept. of Anesthesiology Faculty Page
School of Medicine Faculty Profile

Education:

University of Tennessee at Martin
BSc, Chemistry, 1970

University of Tennessee Center for the Health Sciences
PhD, Biochemistry. 1974

Post-Graduate Training:

Cornell University, Ithaca, NY
Postdoctoral Fellow, 1974-6

Duke University Medical Center, NC
Postdoctoral Fellow 1976-80

Research Interests:

1. Biological roles of nitric oxide and reactive oxygen species: a.Basic studies: Biochemistry and molecular biology of NO and its interactions at the cellular and subcellular levels; cultured cells (hepatocytes, erythrocytes, lymphocytes, mammalian cell lines, bacteria) and isolated proteins (iron-sulfur proteins, electron transferring enzymes) and membranes; Dynamics of NO in blood and tissue: Kinetics, modeling b.Biomedical studies: Roles of NO in injury (inflammation, infection, ischemia/reperfusion) dealing particularly with interactions between NO and reactive oxygen species; Hemoglobin in blood as a major determinant of the biomedical actions of NO; - Biological mechanisms of nitrosation from NO c.Techniques and applications: Electron paramagnetic resonance spectroscopy for in vitro and in vivo detection of NO and its actions; Electrochemical detection of NO; Determination of enzymatic, cellular, organ, and organismal damage from reactive oxygen intermediates; Measurement of cellular enzymatic activities (including the enzymatic synthesis of NO), spectroscopic properties, and metabolism; Methodologies in membrane biochemistry/biophysics; Computer modeling of diffusion/reaction

2.Molecular mechanisms of enzyme-catalyzed electron transfer and biological energy transfer: a.- Conservation of energy coupling in electron transfer and membrane transport of solutes and ions

3.Cellular and biochemical mechanisms of cytokine function: a.- Cytokine production and their effects during immune activation (sepsis, allograft rejection) and oxidative injury during disturbances in oxygen metabolism (ischemia/reperfusion, sepsis, oxidative burst)

Publications

DRC Membership Category:

Senior Scientist