Adam R. Wende, PhD

Adam-Wende 1Assistant Professor

Dept. of Pathology
Division of Molecular and Cellular Pathology

Contact Information:

Office Address: VH G109F
Phone: (205) 975-6272
E-mail: arwende@uab.edu
Websites: School of Medicine Faculty Profile

Education:

Knox College, Galesburg, IL; 1996-2000 B.A. Double major Biochemistry and Biology
Washington University, Saint Louis, MO; 2000-2006 Ph.D. Molecular and Cellular Biology

Post-Graduate Training:

University of Utah, Salt Lake City, UT; 2006-2009 American Heart Association Postdoctoral Fellow
University of Utah, Salt Lake City, UT; 2009-2012 JDRF Advanced Postdoctoral Research Associate

Research Description:

Work in the laboratory has two primary goals: 1) to determine the role of metabolic substrate switching in the hearts of individuals with diabetes or heart failure, and 2) to define the role of cellular glucose delivery on post-translational regulation of mitochondrial enzyme activity and epigenetic regulation of gene expression that together may lead to the development of diabetic cardiomyopathy. The primary goal of the NIH R00 funded research is to determine the role the protein post-translational modification O-GlcNAc has in regulating cardiac cellular function and define the role that changes in glucose levels have on long-lasting epigenetic regulation of gene expression in a process termed “glycemic memory”. By defining these molecular signatures of altered protein regulation and DNA structure/regulation we aim to provide critical knowledge to determining future therapeutic interventions for diabetic and heart failure patients. A secondary project in the laboratory is determining the role that mitochondrial substrate switching has in the adaptations to stress.


Publications


DRC Membership Category:

Scientist