Majd Zayzafoon, MD, PhD

Zayzafoon-MajdAssociate Professor

Dept. of Pathology

Contact Information:

Office Address: Shelby 813
Phone: 205-934-5574
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Websites: School of Medicine Faculty Profile

Education:

Damascus University School of Medicine, Syria
MD, 1987

Michigan State University, East Lansing, MI

PhD, 2001

Post-Graduate Training:

Preston Hospital, Tyne & Wear, Great Britain
Resident, Internal Medicine, 1988-92

Preston Hospital, Tyne & Wear, Great Britain
Fellow, Gastroenterology, 1992-5

Michigan State University, East Lansing, MI
Postdoctoral Fellow, 2001-2

University of Alabama at Birmingham

Postdoctoral Fellow, 2002-5

Research Description:

The long-term goal of my laboratory is to develop novel therapeutic approaches for building and retaining bone mass in humans. Our research activities include understanding the transcriptional regulation of osteoblast differentiation and the role of calcium signaling in this process. We particularly examine the roles of calmodulin dependent protein kinase II and the nuclear factor of activated T-cells in the regulation of osteoblast proliferation and differentiation. We also study the mechanisms involved in the development of bone tumors such as osteosarcoma or bone metastasis from other tumors such as prostate cancer. The outcome of these studies will not only increase our understanding of the regulation of osteoblast differentiation and the growth of bone tumors, but also play a key role in the development of new targets for drug design and therapies for osteoporosis and bone tumors.

Publications

DRC Membership Category:

Senior Scientist