Janusz H. Kabarowski, PhD

KabarowskiAssociate Professor

Dept. of Microbiology

Contact Information:

Office Address: BBRB 334
Phone: 205-996-2082
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Websites:   Dept. of Microbiology Faculty Page
                  School of Medicine Faculty Profile

Education:

Leukaemia Research Fund centre
The Institute of Cancer Research (Chester Beatty Laboratories)
PhD, Leukemia, 1997

Post-Graduate Training:

University of California at Los Angeles 
Postdoctoral Fellow, Immunobiology, 1998-2003

Research Interests:

Lipids and lipoprotein metabolism in chronic inflammatory disease

Research Description:

Dr. Kabarowski’s research program is focused on the study of lipids and lipoprotein metabolism in chronic inflammatory disease (notably atherosclerosis and autoimmune disease). Early work characterized the role of the G2A lipid receptor in atherosclerosis and lipoprotein metabolism, showing that pro-atherogenic effects of this receptor may be mediated through its modulatory influence on hepatic High-Density Lipoprotein (HDL) biogenesis. More recently, Dr. Kabarowski’s group described autoimmune-mediated effects on HDL metabolism in normolipidemic mouse models of Systemic Lupus Erythematosus (SLE) and currently a major effort of his laboratory is directed toward developing therapeutic approaches by which anti-inflammatory and immunosuppressive properties of HDL may be harnessed to improve major Lupus phenotypes and combat premature atherosclerosis, a major cause of morbidity and mortality in this and other rheumatic autoimmune diseases. Emphasis is placed on determining the mechanisms by which protective anti-inflammatory properties of HDL are subverted by chronic inflammation, understanding how this influences immunoregulatory processes involved in SLE and atherosclerosis, and establishing the therapeutic efficacy of HDL-targeted approaches such as HDL mimetic peptides in SLE and other autoimmune diseases.

Publications

DRC Membership Category:

Senior Scientist