John C. Chatham, DPhil

Chatham-JohnProfessor
Dept. of Medicine
Division of Cardiovascular Disease

Contact Information:

Office Address: MCLM 684
Phone: 205-934-0240
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Websites: School of Medicine Faculty Profile

Education:

University of Southampton, England 
BSc, Chemistry, 1983

University of Oxford, England 
DPhil, Biochemistry, 1987

Post-Graduate Training:

Huntington Medical Research Institutes Pasadena, CA 
Postdoctoral Fellow, 1987

Johns Hopkins University School of Medicine Baltimore, MD
Postdoctoral Fellow, 1987-9

Research Description:

The overall goal of my laboratory is to understand the impact of alterations in cardiac energy metabolism and substrate utilization on the cardiomyocyte function.  We have three major areas of interest:

  1. Investigating the mechanisms leading to the increased incidence of heart failure in patients with diabetes
  2. Development of new metabolically based therapeutic interventions for the treatment of ischemic heart disease
  3. Development of metabolic interventions to improve outcomes following trauma and hemorrhage

A common theme to all these projects is the role of glucose in post-translational modifications of proteins mediated by the hexosamine biosynthesis pathway leading to protein-O-glycosylation.  We propose that this is a central mechanism by which changes in metabolism are transduced into alterations in cellular function.

Publications

DRC Membership Category:

Senior Scientist