|November 2012 Research Spotlight: Dr. Xiaoli Li & Dr. Julie Baskin|
Dr. Xiaoli Li & Dr. Julie Baskin's paper entitled "The Unique Cytoplasmic Domain of Human FcγRIIIA Regulates Receptor-Mediated Function", published in the Journal of Immunology has been selected as the Department's paper of the month for November 2012.
Dr. Xiaoli Li obtained a diploma in Biochemistry and a Master’s in virology both from Wuhan University, China. In 1992 he obtained a Ph.D. in Immunology from UAB. After a postdoctoral fellowship at Cleveland Clinic Foundation and a year as Instructor at Rush Medical Center, he returned to UAB where he joined Dr. Kimberly’s group. He is currently Assistant Professor in the Division of Clinical Immunology and Rheumatology.
Dr. Li's current work combines the use of functional genomic analysis and high content multi-chromatic flow cytometry analyses to understand the effects of natural gene polymorphisms of FcγR genes, their unique regulation, and the associated down-stream signaling events in SLE autoimmunity.
Dr. Baskin received a B.S. in Zoology from the University of Massachusetts at Amherst in 1980, her M.S. in Biology from Georgetown University in 1982, and her Ph.D. in Cell and Molecular Biology from the University of Alabama at Birmingham in 1991. She was awarded an Immunologic Diseases and Basic Immunology Training Grant fellowship and joined the laboratory of Dr. Ed Lamon where she investigated idiotypic network activation to the hapten 2, 4 dinitrophenyl (DNP) and antibody-induced inhibition of sarcoma growth using monoclonal antibodies specific for Moloney murine sarcoma/leukemia cell surface antigen. More recently, Dr. Baskin worked in the laboratory of Dr. Robert Kimberly where she had been investigating the role of protein kinase C (PKC) phosphorylation of the alpha-chain cytoplasmic domains of gamma-chain associated Fc receptors. Research interests include receptor-initiated cell signalling and the contribution of the α-chain cytoplasmic domain to downstream cellular responses.
Dr. Robert Kimberly's research group is interested in the role of genetic factors in the normal function of the immune system and in development of autoimmune and immune-mediated inflammatory diseases such as systemic lupus erythematosus and systemic vasculitis. Our approach has focused on receptors for immunoglobulin (Fc receptors) as a model system and has explored molecular mechanisms of receptor signaling and the molecular basis for receptor polymorphisms in humans. Allelic variations in receptor structure profoundly affect receptor function. Our group has been a leader in developing several national research consortia for the study of human diseases, and we have demonstrated that certain low-binding alleles are enriched in SLE patients. More active alleles are over-represented in patients with vasculitis and severe renal disease.
J Immunol. 2012 Nov 1;189(9):4284-94. doi: 10.4049/jimmunol.1200704. Epub 2012 Sep 28.