Associate Professor of Medicine
Dr. Gupta’s research program focuses on questions in the areas of both clinical and experimental pathophysiology. He is using advanced imaging modalities including cardiac magnetic resonance imaging (cMRI) to non-invasively characterize cardiovascular mechanics for the early detection and diagnosis of cardiovascular pathology. Dr. Gupta’s group is also studying anti-inflammatory mechanisms associated with administration of apolipoprotein mimetic peptides developed in the laboratory of G.M. Anantharamaiah. The current study describes protective effects of an apoA-I mimetic peptide in the context of acute respiratory distress syndrome secondary to sepsis.
The June 2013 Research Spotlight features two first co-authors:
Mr Jagirdar holds a M Sc in Biotechnology and M S in Cellular and Molecular Biology. He has developed his career through research as Research assistant/Associate during 2004-2012 in part at University of Michigan. During his time at UAB Mr Jagirdar was instrumental in augmenting pleural research with an emphasis on dissecting the role of the pleural mesothelial compartment in the etiology of Idiopathic Pulmonary Fibrosis. Mr Jagirdar left UAb in Dec 2011 and now runs Geneclick.org, a non profit Bioinformatics & Computational Biology service.
Dr. Jason Zolak received his B.S. degree in neurobiology and physiology from the University of Maryland, and his medical degree from the University of Virginia. He completed a surgery internship, followed by an internal medicine residency at UAB in 2010. He will complete his fellowship in pulmonary and critical care medicine in June of 2013. Dr. Zolak has a clinical interest in pleural disease and malignancy. In conjunction with Dr. Veena Antony, he has investigated the role of pleural mesothelial cells in fibrogenic lung injury. They have demonstrated the novel finding that pleural mesothelial cells undergo differentiation with acquisition of mesenchymal phenotypic characteristics and migrate into the lung parenchyma in fibrogenic lung injury. They have further elucidated a potentially protective role for the induction of heme oxygenase-1 in idiopathic pulmonary fibrosis. They continue to investigate the role of pleural-based therapies for parenchymal diseases.
Mr. Hao Li received his M.S. degree from the Institute of Medicinal Biotechnology of the Chinese Academy of Medical Science in 2005. He joined the Graduate Program in Microbiology at UAB in 2008 and has carried out his graduate study in Dr. John Mountz laboratory at UAB since 2008. Mr. Li initially studied the role of IL-23 in the regulation of autoimmune disease in the BXD2 mouse model of systemic autoimmunity. These mice develop spontaneous germinal centers (GCs) in the spleen that are highly dependent of interleukin (IL)-17. Mr. Li made the novel and unexpected finding that IL-23 was necessary to maintain the integrity of marginal zone barrier that prevents follicular entry of apoptotic self-antigens in BXD2 mice. This initial work led to his present findings of a novel mechanism of autoimmunity in which “leaks” in the marginal zone barrier enable entry of apoptotic Ags into the follicle Mr. Li currently studies the molecular mechanisms regulating the interactions of marginal zone macrophages and marginal zone B cells in maintaining the tolerogenic function of these cells to apoptotic self-antigens.