April 2014 Research Spotlight: Ruizhong Shen

ruizhong shenDr. Ruizhong Shen received his B.S. in Virology and Molecular Biology from Wuhan University, P.R. China, and his Ph.D. in Genetics from Iowa State University.  His post-doctoral fellowship was with Dr. Gail Wertz in the Department of Microbiology at UAB.  He joined the Department of Medicine in 2006 and was promoted to Assistant Professor in 2008.
Dr. Shen’s research interests focus on two areas: the regulation of HIV-1 replication in mucosal cells and the immunobiology of HIV-1 transmission in genital and gut mucosae.  His recent studies have elucidated the role of vaginal and intestinal macrophages and dendritic cells in HIV-1 infection, antibody inhibition of HIV-1 transcytosis across rectal mucosa, the role of intestinal microenvironment on HIV-1 infection, the role of envelope glycan moieties on the major events of HIV-1 mucosal transmission, and the effect of breast milk on mother-to-child transmission.   He has been publishing in Journal of Virology, Journal of Immunology, Journal of Biological Chemistry, Mucosal Immunology, PLoS Pathogens and others.  His work is currently supported by NIH, UAB CFAR and UAB Cancer Center.
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March 2014 Research Spotlight: Zhi-Xiang Xu

picture-1Dr. Xu is currently an Assistant Professor in the UAB Division of Hematology/Oncology, and a Scientist at the UAB Comprehensive Cancer Center. He received his BS degree and PhD degree from Soochow University, China. He completed a Postdoctoral Fellowship at the Department of Molecular Pathology at the University of Texas, MD Anderson Cancer Center, and as Assistant Professor at MD Anderson Cancer Center before joining the UAB Division of Hematology/Oncology in 2009.
Dr. Xu's research focuses on identification of molecular mechanisms underlying tumor suppressor function and to develop pharmacological agents that can modulate or mimic tumor suppressors for cancer prevention and treatment.
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February 2014 Research Spotlight: Xinrui Li

Xinrui Li photoDr. Xinrui Li received her B.S. in Life Sciences from Fudan University, China in 2003, and her Ph.D. in Cell Biology from the University of Alabama at Birmingham in 2009. She conducted her postdoctoral training under Dr. Robert Kimberly and Dr. Jeff Edberg.  She is currently an Instructor in the Division of Clinical Immunology and Rheumatology. She is interested in identifying genetic and epigenetic factors associated with systemic autoimmune diseases and delineating how these factors impact biological outcomes.  
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January 2014 Research Spotlight: David A. Calhoun

CalhounDavid A. Calhoun, MD, Professor of Medicine
Dr. David Calhoun is a Professor of Medicine in the Division of Cardiovascular Diseases at the University of Alabama at Birmingham (UAB).  Dr. Calhoun is also a faculty member of the UAB Sleep/Wake Disorders Center.  Dr. Calhoun received his undergraduate and medical degrees from the University of Virginia, Charlottesville, Virginia and then completed his internal medicine residency training at UAB.  After residency, he did a post-doctoral research fellowship with Dr. Suzanne Oparil.   As current Medical Director of the Vascular Biology and Hypertension Program, Dr. Calhoun oversees all clinical research within the Hypertension Program.  Dr. Calhoun's laboratory has been focused on identifying mechanisms of treatment resistant hypertension.  Important findings from this line of work have included identification of hyperaldosteronism as an important cause of antihypertensive treatment failure, benefit of mineralocorticoid receptor antagonists for resistant hypertension, and aldosterone excess as an important mediator of the severity of obstructive sleep apnea.
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