National Exercise Clinical Trials Network (NExTNet)

Exercise profoundly influences virtually all aspects of human biology; yet major knowledge gaps remain. The National Exercise Clinical Trials Network (NExTNet) was established to facilitate multi-site exercise clinical trials to address these knowledge gaps in a disease-specific or population-specific manner. Currently 59 institutions from coast to coast are members of the growing network. Among NExTNet’s primary functions is to foster standardization of procedures for rigorous multi-site trials. The University of Alabama at Birmingham (UAB) Center for Exercise Medicine serves as the NExTNet Coordinating Center.

NExTNet Vision

To transform biomedical research, clinical care and, ultimately, global health by providing the evidence base that will optimize exercise prescription and lifestyle intervention strategies in a disease-specific and population-specific manner.

NExTNet Mission Statement

To achieve its vision, NExTNet will lead and facilitate rigorous, multi-institutional, trans-disciplinary research to address key knowledge gaps in:

Exercise Biology

•       Mechanisms driving dose-response relationships.
•       Genetic and phenotypic variations in responsiveness.
•       Mechanisms by which physical inactivity fosters development and progression of CNCDs.
•       Taking advantage of the potent exercise stimulus to discover new pathways and molecular targets.

Exercise-Drug/Device Interactions

•       Differences in drug/device efficacy between active and inactive individuals.
•       Synergism, antagonism, drug metabolism.
•       Drug re-purposing based on exercise responses.

Exercise Psychology/Behavioral Medicine

•       Genetic and non-genetic determinants of exercise adherence and lasting lifestyle modification.

Clinical Application

•       Optimizing disease-specific and population-specific exercise dosing/prescription to streamline clinical care.