Metformin to Augment Strength Training Effective Response in Seniors

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Strength exercise training is the most effective intervention identified to combat loss of muscle function with advancing age; however, the response to exercise is blunted and highly variable in older adults. This randomized, placebo-controlled trial – a collaboration between two major academic medical centers (University of Kentucky and University of Alabama at Birmingham) – is designed to determine if the addition of a medication (metformin) will improve the effectiveness of strength training in older adults. The overall goal is to establish a low cost, personalized approach to prevent frailty in older adults.

Funding: National Institutes of Health, National Institute on Aging (Grant #1R01AG046920)

Investigators: Charlotte Peterson, PhD, and Phil Kern, MD, University of Kentucky; Marcas Bamman, PhD, University of Alabama at Birmingham

Participants: 65+ years of age; no history of diabetes; no intensive strength training during the past three years; access to transportation; must meet all other inclusion and exclusion criteria.

Benefits: Supervised exercise training 3 days per week for 14 weeks with certified trainers in a clinical research setting; free assessments of health and functional status, body composition, and fitness; opportunity to play a pivotal role in biomedical research that will advance personalized exercise medicine for older adults.

If you may be interested in participating and want to learn more, please complete the questionnaire below and a member of our research staff will contact you soon. You may also email masterstrial@uab.edu or call 205-996-4086. Thank you for your interest.


MASTERS Trial Interest Form

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