C. Roger White, Ph.D.
Dr. White received his undergraduate degree in economics from Lake Forest College, IL, and then a M.S. and Ph.D. in physiology and biophysics from the University of Illinois in Urbana, IL. After a post-doctoral fellowship at UAB in the vascular biology and hypertension program, he joined the UAB faculty, achieving Associate Professor of Medicine in the Division of Cardiovascular Disease in 2001.
Dr. White’s research program focuses on two areas: (1) the mechanism of oxidative tissue injury in models of acute and chronic inflammation; and (2) the role of dyslipidemia in the development of inflammation and diabetic vascular complications. An altered metabolism of lipoproteins is thought to contribute to increased cardiovascular risk and vascular remodeling. The role of macrophages in mediating vascular inflammation in the setting of altered lipid metabolism is also a topic of study.
- White, C.R., Brock, T.A., Chang, L.Y., Crapo, J., Briscoe, P., Ku, D., Bradley, W.A., Gianturco, S., Gore, J., Freeman, B.A. and Tarpey, M.M. Superoxide and peroxynitrite in atherosclerosis. Proceed. Natl. Acad. Sci. USA. 91:1044-1048, 1994.
- White, C.R., Darley-Rsmar, V., McAdams, M., Berrington, W.R., Gore, J., Thompson, J.A., Parks, D.A., Tarpey, M.M. and Freeman, B.A. Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits. Proceed. Natl. Acad. Sci. USA. 93:8745-8749, 1996.
- White, C.R., Shelton, J., Chen, S.J., Durand, J., Allen, L., Darley-Usmar, V., Nabors, C., Sanders, P.W., Chen, Y.F. and Oparil, S. Estrogen restores endothelial cell function in an experimental model of vascular injury. Circulation 96:1624-1630, 1997.
- Zhang, C., Kelpke, S., Ma, W., Zhou, F., Parks, D.A., Darley-Usmar, V. and White, C.R. Endothelial dysfunction is induced by the proinflammatory oxidant hypochlorous acid. Am. J. Physiol.281:H1469-H1475, 2001.
- Zhang, C., Reiter, C., Eiserich, J.P., Darley-Usmar, V.M., Parks, D.A., Beckman, J.A., Barnes, S., Kirk, M., Baldus, S. and White, C.R. L-arginine chlorination products inhibit endothelial nitric oxide production. J. Biol. Chem. 276:27159-27165, 2001.
- Eiserich, J.P., Baldus, S., Brennan, M.L., Ma, W., Zhang, C., Tousson, A., Castro, L., Lusis, A.J., White, C.R. and Freeman, B.A. Myeloperoxidase: a leukocyte-derived vascular NO oxidase. Science296:2391-2394, 2002.
- Shelton, J., Gupta, H., Grenett, H., Wong, D., Wyss, J.M., Oparil, S. and White, C.R. The neointimal response to endovascular injury is enhanced in obese zucker rats. Diabetes Obes. Metab. 5:415-423, 2003.
- White, C.R., Parks, D.A., Patel, R.P., Shelton, J., Tarpey, M.M., Freeman, B.A. and Darley-Usmar, V.M. L-arginine supplementation inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia. FEBS Lett. 561:94-98, 2004.
- Gupta, H., Dai, L., Datta, G., Garber, D.W., Grenett, H., Li, Y., Mishra, V., Palgunachari, M.N., Handattu, S., Gianturco, S.H., Bradley, W.A., Anantharamaiah, G.M. and White, C.R. Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein A-I mimetic peptide. Circ. Res. 97:2365-243, 2005.
- Peng, N., Clark, J.T., Prasain, J., Kim, H., White, C.R. and Wyss, J.M. Antihypertensive and cognitive effects of grape polyphenols in estogent-depleted, female spontaneously hypertensive rats. Am.J. Physiol. 289:R771-R775, 2005.