Phillip Smith, MD, Professor, MHIC Director

phillip_smithDr. Smith earned his B.A. from the University of California at Berkeley in pre-medical sciences and anthropology and his M.D. from the University of Rochester, N.Y. After residency in internal medicine at Vanderbilt and a fellowship in gastroenterology at the University of Colorado, which included training in clinical parasitology at the University of Natal in Durban, S. Africa, he did a postdoctoral fellowship in parasite immunology in the Laboratory of Parasitic Diseases, NIAID, NIH and then joined the Laboratory of Cellular Immunology, NIDCR, NIH, where he was a Senior Investigator until joining the UAB Department of Medicine in 1993.  Dr. Smith is currently a Professor and the Director of theMucosal HIV and Immunobiology Center (MHIC) at UAB. 

Recent Publications
Downregulated TH17 responses are associated with reduced gastritis in Helicobacter pylori-infected children. Serrano C, Wright SW, Bimczok D, Shaffer CL, Cover TL, Venegas A, Salazar MG, Smythies LE, Harris PR, Smith PD.
Mucl Immunol 6:950-959, 2013.

Intestinal macrophages and response to microbial encroachment.
Smith PD, Smythies LE, Shen R, Greenwell-Wild T, Gliozzi M and Wahl SM.
Muc Immunol 4:31-42, 2011.

Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages.
Shen R, Meng G, Ochsenbauer C, Clapham PR, Grams J, Novak L, Kappes JC, Smytheis LE and Smith PD.
PLoS Pathol 7(5):e1002060, 2011.

Human intestinal macrophages display profound inflammatory anergy despiet avid pahobytic and bacteriocidal activity.
Smythies LE, Sellers M, Clements R, Mosteller-Barnum M, Meng G, Benjamin WH, Orenstein JM and Smith PD.
J Clin Invest
115:66-75, 2005.

Intestinal macrophages: unique effector cells of the innate immune system.
Smith PD, Ochsenbauer-Jambor C, Smythies LE.
Immunol Rev 206:149-59, 2005.

Macrophage HIV-1 infection and the gastrointestinal tract reservoir.
Smith PD, Meng G, Salazar-Gonzalez JF, Shaw GM.
J Leukoc Biol 74:642, 2003.

Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells.
Meng G, Wu X, Wei X, Sellers MT, Decker JM, Moldoveanu Z, Kappes JC, Mestecky J, Shaw GM, Smith PD.
Nat Med 8:150-6, 2002.

Quantitative analysis of mononuclear cells expressing HIV-1 RNA in esophageal mucosa.
Smith PD, Fox CH, Masur H, Winter HS, Alling DW.
J Exp Med 180:1541-6, 1994.

Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa.
Mai UEH, Perez-Perez GI, Allen JB, Wahl SM, Blaser MJ, Smith PD.
J Exp Med 175:517-25, 1992.


Cytomegalovirus induces expression of tumor necrosis factor by human monocytes and mucosal macrophages.
Smith PD, Saini SS, Raffeld M, Manischewitz JF, Wahl SM.
J Clin Invest 90:1642-8, 1992.

Soluble surface prtoeins from Helicobacter pylori activate monocytes/macrophages by a lipopolysaccharide-independent
mechanism.
Mai UEH
, Perez-Perez GI, Wahl LM, Wahl SM, Blaser MJ, Smith PD.
J Clin Invest 87:894-900, 1991.

Monocyte function in the acquired immune deficiency syndrome: Defective chemotaxis.
Smith PD, Ohura K, Masur H, Lane HC, Fauci AS, Wahl SM.
J Clin Invest 74:2121-8, 1984.