Dr. Smith earned his B.A. from the University of California at Berkeley in pre-medical sciences and anthropology and his M.D. from the University of Rochester, N.Y. After residency in internal medicine at Vanderbilt and a fellowship in gastroenterology at the University of Colorado, which included training in clinical parasitology at the University of Natal in Durban, S. Africa, he did a postdoctoral fellowship in parasite immunology in the Laboratory of Parasitic Diseases, NIAID, NIH and then joined the Laboratory of Cellular Immunology, NIDCR, NIH, where he was a Senior Investigator until joining the UAB Department of Medicine in 1993. Dr. Smith is currently a Professor and the Director of the Mucosal HIV and Immunobiology Center (MHIC) at UAB.
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Downregulated TH17 responses are associated with reduced gastritis in Helicobacter pylori-infected children. Serrano C, Wright SW, Bimczok D, Shaffer CL, Cover TL, Venegas A, Salazar MG, Smythies LE, Harris PR, Smith PD. Mucl Immunol 6:950-959, 2013.
Intestinal macrophages and response to microbial encroachment. Smith PD, Smythies LE, Shen R, Greenwell-Wild T, Gliozzi M and Wahl SM. Muc Immunol 4:31-42, 2011.
Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages. Shen R, Meng G, Ochsenbauer C, Clapham PR, Grams J, Novak L, Kappes JC, Smytheis LE and Smith PD. PLoS Pathol 7(5):e1002060, 2011.
Human intestinal macrophages display profound inflammatory anergy despiet avid pahobytic and bacteriocidal activity. Smythies LE, Sellers M, Clements R, Mosteller-Barnum M, Meng G, Benjamin WH, Orenstein JM and Smith PD. J Clin Invest 115:66-75, 2005.
Intestinal macrophages: unique effector cells of the innate immune system. Smith PD, Ochsenbauer-Jambor C, Smythies LE. Immunol Rev 206:149-59, 2005.
Macrophage HIV-1 infection and the gastrointestinal tract reservoir. Smith PD, Meng G, Salazar-Gonzalez JF, Shaw GM. J Leukoc Biol 74:642, 2003.
Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Meng G, Wu X, Wei X, Sellers MT, Decker JM, Moldoveanu Z, Kappes JC, Mestecky J, Shaw GM, Smith PD. Nat Med 8:150-6, 2002.
Quantitative analysis of mononuclear cells expressing HIV-1 RNA in esophageal mucosa. Smith PD, Fox CH, Masur H, Winter HS, Alling DW. J Exp Med 180:1541-6, 1994.
Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. Mai UEH, Perez-Perez GI, Allen JB, Wahl SM, Blaser MJ, Smith PD. J Exp Med 175:517-25, 1992.
Cytomegalovirus induces expression of tumor necrosis factor by human monocytes and mucosal macrophages. Smith PD, Saini SS, Raffeld M, Manischewitz JF, Wahl SM. J Clin Invest 90:1642-8, 1992.
Soluble surface prtoeins from Helicobacter pylori activate monocytes/macrophages by a lipopolysaccharide-independent mechanism. Mai UEH, Perez-Perez GI, Wahl LM, Wahl SM, Blaser MJ, Smith PD. J Clin Invest 87:894-900, 1991.
Monocyte function in the acquired immune deficiency syndrome: Defective chemotaxis. Smith PD, Ohura K, Masur H, Lane HC, Fauci AS, Wahl SM. J Clin Invest 74:2121-8, 1984.