Comparative Pathology Laboratory

Director: Trenton R. Schoeb, D.V.M., Ph.D., DACVP

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Phone: (205) 934-2288

• Research animal histology: Routine and special paraffin processing, embedding, and sectioning; frozen sections; routine and special stains
• Veterinary clinical pathology: Hematology; clinical chemistry; urinalysis
• Training: Animal necropsy technique; tissue collection, fixation, and trimming; sample collection for clinical pathology
• Consultation: Animal pathologic techniques; design of experiments requiring collection of anatomic or clinical pathologic data from research animals
• Collaborative research support: Analysis of disease expression in animal models; pathologic phenotyping of genetically engineered mice; gross and microscoping photography; animal pathology cores for program projects

Epitope Recognition and Immunoreagent Core Facility (ERIC)

Director: Mary Ann Accavitti-Loper, Ph.D.

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Phone: (205) 934-0913

• Monoclonal antibody development and large-scale production
• Vaccine design (peptides, proteins, gel slices, viruses, cells, TFcells)
• Strategic immunization protocols:
  • Subtractive immunization
  • Knock-out mice
  • CDR-3 altered mice
• Large-scale Mab production and purification
• Epitope differentiation (oligoclonal antiserum design)
• Anti-tag Mabs (i.e. Myc, Flag, HA, GST, GFP) and isotype-matched controls

Heflin Center for Genomic Science Core Facility

Director: Molly Bray, Ph.D.
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Phone: (205) 975-7651

Associate Director: Mike Crowley, Ph.D.
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Phone: (205) 975-2013

Bioinformatics Director: David Crossman, Ph.D.
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Phone: (205) 996-4045 

• The Cores are available to anyone wishing to access state-of-the-art genomics and genetic technologies.
• Illumina Next-Generation Sequencing (NGS) Consultative and Experimental services are now available.
• The Illumina Core has the latest in DNA analysis technology including the iSCAN and BeadXpress systems for:
• Large and medium scale SNP genotyping
• Human DNA methylation analysis
• Gene expression analysis and more
• The Genomic Core facility provides:
• DNA sequencing
• SNP genotyping
• Human cell line DNA fingerprinting
• Affymetrix gene expression arrays
• Discount oligonucleotides from IDT
• The Genomic Core also provides comprehensive data analysis services for microarrays, NGS and more.

Transgenic Mouse Facility

Director: Bob Kesterson, Ph.D.

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Phone: (205) 934-7206

• We provide all services related to genetically modified mouse models (transgenic and knockout).
• Services:
  • DNA or ES cell microinjection
  • ES cell gene targeting
  • Assisted reproduction and line cryopreservation
  • Consultations and custom services developed as needed.
• New equipment: Autogen965 high-throughput DNA isolation robot; 384 samples/4 hrs (mouse tails, ES cells, plasmids, BACs)