Edlue Tabengwa, PhD

Rank: Assistant ProfessorTabengwa Edlue - Copy small

Division: Hematology & Oncology

Campus Address: SHEL

Phone: (205) 975-0963

Email: tabengwa@uab.edu

Departmental Affiliation(s):
Primary: Medicine

Biosketch:

Research Interests:
Dr. Tabengwa joined Dr. Randall Davis’ laboratory July 1, 2010 as an Assistant Professor with a strong scientific background to help establish and lead the management of a new facility on campus termed the Multidisciplinary Molecular Interaction Core (MMIC). This facility supports an NIH-funded Biacore T200 instrument that enables the characterization of protein-protein and other biomolecular interactions by surface plasmon resonance (SPR) technology. She has led in the establishment of this facility and instrumentation which has quickly grown under her management. She currently manages and operates the instrument, trains and educates new and established users, and analyzes data generated from this valuable resource for a current user base of eight different laboratories including Dr. Davis’.

Publications:

  1. Li X.N., Varma V.K., Parks J.M., Benza R.L., Koons J.C., Grammer J.R., Grenett H.E., Tabengwa E.M., Booyse F.M.: Thrombin decreases the urokinase receptor and surface-localized fibrinolysis in cultured endothelial cells. (1995) Arterioscler Thromb Vasc Biol. 15: 410-419. PMID:7749851
  2. Li X.N., Koons J.C., Benza R.L., Parks J.M., Varma V.K., Bradley W.A., Gianturco S.H., Taylor K.B., Grammer J.R., Tabengwa E.M., Booyse F.M.: Hypertriglyceridemic VLDL decreases plasminogen binding to endothelial cells and surface-localized fibrinolysis. (1996) Biochemistry35: 6080-6088. PMID:8634250
  3. Aikens M.L., Grenett H.E., Benza R.L., Tabengwa E.M., Davis G.C., Demissie S., Booyse F.M.: Ethanol increases surface-localized fibrinolytic activity in cultured endothelial cells. (1997) Alcohol Clin Exp Res. 21: 1471-1478. PMID:9394120
  4. Li X.N., Grenett H.E., Benza R.L., Demissie S., Brown S.L., Tabengwa E.M., Bradley W.A., Gianturco S.H., Fless G.M., Booyse F.M.: Genotype-specific transcriptional regulation of PAI-1 expression by hypertriglyceridemic (HTG)-VLDL and Lp(a) in cultured human endothelial cells. (1997) Arterioscler Thromb Vasc Biol. 17: 3215-3223. PMID:9409314
  5. Grenett H.E., Aikens M.L., Tabengwa E.M., Davis G.C., Booyse F.M.: Ethanol downregulates transcription of the PAI-1 gene in cultured human endothelial cells. (2000) Thromb Res. 97:247-255. PMID:10674412
  6. Tabengwa E.M., Abou-Agag L.H., Benza R.L., Torres J.A. Aikens M.L., Booyse F.M.: Ethanol-induced upregulation of candidate plasminogen receptor annexin II in cultured human endothelial cells. (2000) Alcohol Clin Exp Res. 24(6):754-761. PMID:10888061
  7. Tabengwa E.M., Benza R.L., Grenett H.E., Booyse F.M.: Hypertriglyceridemic VLDL downregulates tissue plasminogen activator gene transcription though cis-repressive region(s) in the tissue plasminogen activator promoter in cultured human endothelial cells. (2000) Arterioscler Thromb Vasc Biol. 20(6):1675-1681. PMID:10845888
  8. Tabengwa E.M., Grenett H.E., Benza, R.L., Abou-Agag L.H., Tresnak, J.A., Wheeler C.G., Booyse F.M.: Ethanol-induced upregulation of the urokinase receptor in cultured human endothelial cells. (2001) Alcohol Clin Exp Res. 25 (2):163-170. PMID:11236828.
  9. Abou-Agag L.H., Tabengwa E.M., Tresnak, J.A., Wheeler C.G., Taylor K.B., Booyse F.M.: Ethanol-Induced Increased Surface-Localized Fibrinolytic Activity in Cultured Human Endothelial Cells: Kinetic Analysis. (2001) Alcohol Clin Exp Res. 25 (3):351-361. PMID:11290845
  10. Tabengwa E.M., Wheeler C.G., Yancey D.A., Grenett H.E., Booyse F.M.: Alcohol-induced upregulation of fibrinolytic activity and plasminogen activators in cultured human monocytes. (2002) Alcohol Clin Exp Res. 26: (8) 1121-1127. PMID:12198385
  11. Schmidt E., Wehr B., Tabengwa E.M., Reimer S., Brocker E.B., Zillikens D.: Elevated expression and release of tissue-type, but not urokinase-type plasminogen activator, after binding of autoantibodies to bullous pemphigoid antigen 180 in cultured human keratinocytes. (2004) Clin Exp Immunol. 135: 497-504. PMID:15008985
  12. Booyse F.M., Pan W., Grenett H.E., Parks D.A., Darley-Usmar V.M., Bradley K.M., Tabengwa EM: Mechanism by which alcohol and wine polyphenols affect coronary heart disease risk. (2007) Annals of Epidemiol. 17(S5): S24-S31. PMID:17478321
  13. Pasten C., Olave N.C., Zhou L., Tabengwa E.M., Wolkowicz P.E., Grenett H.E.:   Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: Molecular contributor to cardiovascular protection. (2007) Thromb Res. 121 (1): 59-65. PMID:17379280
  14. Pan W., Chang M.J., Booyse F.M., Grenett H.M., Bradley K.M., Wolkowizc P.E., Chang Q., Tabengwa E.M.: Quercetin induced tissue plasminogen activator expression is mediated through Sp1 and p38 mitogen activated protein kinase in human endothelial cells. (2008) J Throb Haemost. (6): 976-985. PMID:18419748
  15. Wolkowicz P.E., Huang J., Umeda P.K., Sharifov O.F., Tabengwa E., Halloran B.A., Urthaler F., Grenett H.E.: Pharmacological evidence for Orai channel activation as a source of cardiac abnormal automaticity. (2011) Eur J Pharmacol. 668(1-2):208-16. PMID:217454