| Alok Mulky, PhD |
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Rank: Assistant Professor Division: Hematology & Oncology Campus Address: LHRB 609 Phone: (205) 934-7046 Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it Departmental Affiliation(s): Primary: Medicine Biosketch: Dr. Alok Mulky received his B.S. and M.S. in Microbiology from the University of Mumbai (1996 and 1998, respectively) and received his Ph.D. in Microbiology from UAB in 2005. Dr. Mulky completed his postdoctoral fellowship studying host proteins involved in HIV-1 replication from the National Cancer Institute in Frederick, Maryland, and joined the UAB faculty in 2011. Research Description: Dr. Mulky's research is focused on characterizing: (i) innate mechanisms for blocking human immunodeficiency virus type 1 (HIV-1) and (ii) host-cell factors required for viral replication. His recent research has focused on investigating proteins in the RNA-induced silencing complex (RISC) and the P body that interact with HIV-1 during viral assembly. His long-term research goal is to comprehensively define the function/s of the RISC and P body during trafficking, assembly and release of HIV-1 from infected cells. In collaboration with Dr. John Kappes (UAB Hem-Onc Division), Dr. Mulky is also involved in research for evaluating the humoral immune response to HIV-1 infection, and in the characterization of antibody response produced in HIV-1 patients and vaccinees. Selected Publications: • Lee, K.*, Mulky, A.*, Yuen, W., Martin, T. D., Meyerson, N. R., Choi, L., Yu, H., Sawyer, S. L., and Kewalramani, V. N. (2012) HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6, J. Virol. 86, 3851-3860. PMID: 22301135 *Equal Contribution • Lee, K., Ambrose, Z., Martin, T. D., Oztop, I., Mulky, A., Julias, J. G., Vandegraaff, N., Baumann, J. G., Wang, R., Yuen, W., Takemura, T., Shelton, K., Taniuchi, I., Li, Y., Sodroski, J., Littman, D. R., Coffin, J. M., Hughes, S. H., Unutmaz, D., Engelman, A., and KewalRamani, V. N. (2010) Flexible use of nuclear import pathways by HIV-1, Cell Host Microbe 7, 221-233. PMID: 20227665 • Furtak, V., Mulky, A., Rawlings, S. A., Kozhaya, L., Lee, K., Kewalramani, V. N., and Unutmaz, D. (2010) Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity, PLoS One 5, e9081. PMID: 20140200 • Mulky, A., Cohen, T. V., Kozlov, S. V., Korbei, B., Foisner, R., Stewart, C. L., and KewalRamani, V. N. (2008) The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections, J. Virol. 82, 5860-5868. PMID: 18400857 • Olivares, I., Mulky, A., Boross, P. I., Tozser, J., Kappes, J. C., Lopez-Galindez, C., and Menendez-Arias, L. (2007) HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions, J. Mol. Biol. 372, 369-381. PMID: 17651754 • Mulky, A., Vu, B. C., Conway, J. A., Hughes, S. H., and Kappes, J. C. (2007) Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication, J. Mol. Biol. 365, 1368-1378. PMID: 17141805 • Chou, C. F., Mulky, A., Maitra, S., Lin, W. J., Gherzi, R., Kappes, J., and Chen, C. Y. (2006) Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay, Mol. Cell. Biol. 26, 3695-3706. PMID: 16648466 • Mulky, A., Sarafianos, S. G., Jia, Y., Arnold, E., and Kappes, J. C. (2005) Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions, J. Mol. Biol. 349, 673-684. PMID: 15893326 • Mulky, A., and Kappes, J. C. (2005) Analysis of human immunodeficiency virus type 1 reverse transcriptase subunit structure/function in the context of infectious virions and human target cells, Antimicrob. Agents Chemother. 49, 3762-3769. PMID: 16127051 • Mulky, A., Sarafianos, S. G., Arnold, E., Wu, X., and Kappes, J. C. (2004) Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo, J. Virol. 78, 7089-7096. PMID: 15194785 |