Research

Research

Research is the third area of excellence in our Division. For 2008, the Division’s federal research awards and industry grants (direct cost) totaled over $21 million. The Division also has two NIH sponsored T32 grant.

Research interests of the Division include:

  • pathogenesis of viral infections, especially human papillomaviruses, herpes simplex, varicella zoster and retroviruses (with emphasis on HIV envelope proteins and structural and functional determinants of cytopathicity);
  • basic and clinical problems in patients with AIDS including natural history, investigational therapy of HIV disease and its complications, and mechanisms of HIV resistance;
  • epidemiology, pathogenesis and therapy of sexually transmitted diseases;
  • antiviral therapy (HSV, VZV and CMV);
  • epidemiology, natural history and therapy of systemic mycoses;
  • host defenses and infectious diseases in immunocompromised patients;
  • vaccine research clinic for clinical testing and laboratory evaluations of candidate HIV vaccines, VZV and HPV vaccines, and anthrax vaccine;
  • travel medicine and international health;
  • integrated malaria control, medical entymology.

The UAB AIDS program is strong in both the clinical and research arenas. The AIDS out-patient clinics currently follow about 1,200 HIV-infected persons exhibiting the full spectrum of clinical manifestations from asymptomatic infection to advanced AIDS, complicated by opportunistic infectious diseases and malignancies. UAB, via the collaborative efforts of faculty in multiple departments, has successfully competed for eight major AIDS-focused research grants sponsored by NIH.

In addition, the NIAID-sponsored multi-center Mycoses Study Group is based in the Division of Infectious Diseases, as is the UAB Sexually Transmitted Diseases Cooperative Research Center and the STD Clinical Trials Unit. The STD programs consist of investigators from not only Infectious Diseases, but also from Obstetrics-Gynecology and Microbiology, as well as the Schools of Public Health, and Social and Behavioral Sciences.