jeanne marrazzo lrg

Professor
Division Director







CURRENT RESEARCH IS CENTERED IN SEVERAL AREAS:

  • Biomedical prevention of HIV, especially evaluation of vaginal and oral pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition in African women
  • Interactions between hormonal contraceptives and cervicovaginal inflammation and infection
  • Molecular epidemiology of the vaginal microbiome, including bacterial vaginosis (BV), and role of newly defined bacteria in the pathogenesis and diagnosis of BV and other inflammatory genital syndromes
  • Sexually transmitted infections and health care seeking behavior in LGBTQ populations, including STD in men who have sex with men and in HIV care settings, cervical neoplasia and BV in women who report sex with women;
  • Diagnosis and epidemiology of bacterial STDs
  • Evaluation of a contraceptive vaginal ring on the vaginal microbiome, local immunity and HIV shedding in Kenyan women
  • Evaluation of a contraceptive vaginal ring on the vaginal microbiome and local immunity in U.S. women

Our work has expanded the microbiologic spectrum of BV-associated organisms, and we continue to study predictors of infection with these bacteria, their role in diagnosis of vaginal infections, the host immune response in BV, and potential reservoirs (including sex partners) that may help explain BVs association with specific sexual practices. We also study the effects that different types of hormonal contraception have on the genital microbiome and on risk of and activity of critical genital infections, including genital herpes and HIV shedding. The major objectives of work related to HIV PrEP is to evaluate the effectiveness of oral vs. vaginally delivered antiretroviral medications in preventing HIV acquisition in young HIV-uninfected women in sub-Saharan Africa. Research related to other STDs seeks to define better treatment for common infections, including gonorrhea and BV. Collaborators in these efforts include UAB colleagues Ned Hook, Latesha Elopre, Jane Schwebke, and Jodie Dionne-Odom, as well as colleagues at the University of Washington (David Fredricks, Thomas Hawn, Sujatha Srinivasan, Christine Johnston and Connie Celum).

As faculty for the Alabama-North Carolina STD Prevention Training Center, I am also invested in delivering and evaluating excellent educational offerings to providers in practice and to medical practitioners in training. See www.nnptc.org for more information.


SELECTED PUBLICATIONS:

  1. Balkus J, Brown E, Palanee T, Gonasagrie N, Gafoor Z, Zhang J, Richardson BA, Chirenje ZM, Marrazzo JM, Baeten J. An empiric HIV risk scoring tool to predict HIV-1 acquisition in African women. JAIDS [in press].
  2. Gorgos Linda M, Sycuro LK, Srinivasan S, Fiedler TL, Morgan MT, Balkus JE, McClelland RS, Fredricks DN, Marrazzo JM. Relationship of specific bacteria in the cervical and vaginal microbiotas with cervicitis. Sex Transm Dis 2015;42(9):475-81. PMID 26267872
  3. Barbee LA, Dhanireddy S, Tat SA, Radford A, Marrazzo JM. Barriers to bacterial STI testing of HIV-infected men who have sex with men engaged in HIV primary care. Sex Transm Dis 2015;42(10):590-4. PMID 26372931
  4. Noguchi LM, Richardson BA, Baeten JM, Hillier SL, Balkus JE, Chirenje ZM, Bunge K, Ramjee G, Nair G, Palanee-Phillips T, Selepe P, van der Straten A, Parikh UM, Gomez K, Piper JM, Watts H, Marrazzo JM. Risk of HIV-1 acquisition among women using different types of injectable progestin contraception in South Africa: a prospective cohort study. Lancet HIV 2015;2(7):e279-e287. PMID 26155597.
  5. Tat S, Marrazzo JM, Graham S. Women who have sex with women living in low- and middle-income countries: a systematic review of sexual health and risk behaviors. LGBT Health 2015,2(2):91-104.
  6. Balkus JE, Nair G, Montgomery ET, Mishra A, Palanee T, Ramjee G, Panchia R, Selepe P, Richardson BA, Chirenje ZM, Marrazzo JM. Age-disparate partnerships and risk of HIV-1 acquisition among South African women participating in the VOICE Trial. JAIDS 2015;70(2):212-7. PMID 26049280
  7. Marrazzo JM, Richardson B, Ramjee G, et al, for the VOICE (MTN 003) Team. Tenofovir-based preexposure prophylaxis for HIV infection among African women. New Engl J Med 2015;372(6):509-18. PMID 25651245
  8. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. New England Journal of Medicine 2005;353:1899-911.


 RECENT NEWS:

  • Jeanne Marrazzo, MD, MPH, has been elected to the American Clinical and Climatological Association.
  • Marrazzo recently featured on Healio.com highlighting her presentation at the ASM Microbe 2016 Conference.  Her address focused on current trends in sexually transmitted infections among patient with HIV, including "really explosive numbers of syphilis cases."
  • Jeanne Marrazzo, MD, selected for one of the "Most Notable Articles for 2015" for her article Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women.


UAB Medicine Physician Profile










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