R. Pat Bucy, MD, PhD

bucyProfessor of Pathology

Director, UAB Hospital Flow Cytometry Lab



Address: Spain Tower, W287
UAB
Birmingham, AL 35294
Telephone: (205) 934-6246
FAX: (205) 975-7074
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


Publications

 

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Education


B.S. (Chemistry), Austin College, Sherman, TX
M.D. Washington University, St. Louis, MO
Ph.D. Washington University, St. Louis, MO
Residency (Anatomic Pathology), Barnes Hospital, St. Louis, MO


Research Interests


Dr. Bucy is interested in the regulation of immune responses by T cells, particularly the forms of regulation that develop in vivo in situations with chronic antigen presence. Conventional experimental systems have used model antigens given in discreet inoculations so that the clearance of antigen is the dominant overall control mechanism. In physiological situations such as solid organ transplantation, chronic viral diseases, and organ specific autoimmune diseases, antigen is usually not cleared, but the immune system develops various control mechanisms that limit immune damage. In addition to his role as the Director of the UAB Medical Scientist Training Program (joint MD/PhD training), Dr. Bucy's lab is engaged in a wide range of projects with a translational focus, that span the gamut of basic mechanistic studies in mice to active design of human clinical trials. Active current projects include use of TCR transgenic mice to study murine heart transplant tolerance, analysis of T cell population dynamics in response to various forms of immunization, studies of viral and cellular dynamics in SHIV infected Rhesus Macaques, and a substantial series of studies focused on therapeutic immunization of HIV infected people and assessment of changes in immune function in these people. In all of these systems, multiple techniques are used including flow cytometry, immunohistochemistry, cell culture techniques, production of novel transgenic mice, real-time RT-PCR,. and in situ hybridization analysis of viral and cellular RNA species.