RamanProfessor of Medicine

Address: 1825 University Blvd
Shelby Building, 305
Birmingham, AL 35294
Telephone: (205) 934-2472
FAX: (205) 934-2542
Email: craman@uab.edu


Members of the Laboratory




B.Sc. (Zoology), Madras University, India
M.Sc. (Microbiology), Idaho State University
Ph.D. (Microbiology-Immunology), Southern Illinois University
Postdoctoral Studies, Loyola University in Chicago, Stritch School of Medicine, with Dr. Katherine Knight

Research Interests

The overall research focus of the laboratory is the elucidation of mechanisms that regulate generation and maintenance of immune tolerance in T and B lymphocytes. Autoimmunity and predisposition to development of leukemias are the often of the outcomes of alterations in generation and/or maintenance of tolerance. The development of inability of T and B lymphocytes to respond to self antigens while maintaining the ability to respond to self antigens is an active process in which the signals initiated by the engagement of the T cell antigen receptor (TCR) or B cell antigen receptor (BCR) are regulated by a complex of other lymphocyte surface molecules. Signaling cascades initiated by these lymphocyte surface molecules range form those that directly alter the quality and quantity of antigen receptor signals to those that promote cell survival or initiate programmed cell death or apoptosis. Our experimental approaches include in vitro structure function studies to define protein-protein interactions to the use of animal models of disease that naturally occur or are genetically created. Currently our focus is on the cell surface receptors CD5, DR6 and the family of receptors that bind to lignads Blys and April. Each of these receptors play a key role in regulating lymphocyte function and homeostasis and alterations in their signaling activities leads to diverse pathologies. The ultimate goal of our studies is to identify key targets for the development of therapeutic strategies for the treatment of leukemias and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.