Phillip Doyle Smith, MD

phillip_smithMary J. Bradford Professor in Gastroenterology
Professor of Medicine and Microbiology


Address: 1825 University Blvd
Shelby, room 610
UAB
Birmingham, AL 35294
Telephone: (205) 975-9254
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Publications

 

__________________________________________________________


Education


B.A., University of California, Berkley, CA
M.D., University of Rochester, Rochester, NY
Internship/Residency in Medicine, Vanderbilt University, Nashville, TN
Fellowship in Gastroenterology, University of Colorado
Postdoctoral Fellow in Parasite Immunology, NIH/NIAID

 

Research Interests


Dr. Smith's laboratory investigates the gastrointestinal immune responses to infectious agents and inflammatory stimuli. The mucosal cell functions currently being investigated include macrophage anergy, T regulatory and helper cell function, virus transcytosis, and the regulation of inflammation. The cellular and molecular basis for these responses are investigated by probing purified intestinal macrophages, intestinal lymphocytes and epithelial cells with pathogens such as cytomegalovirus, HIV-1 and Helicobacter pylori or their purified or cloned products. The goal of these studies is to elucidate the cascade of events that regulate mucosal immune responses to enteric pathogens and inflammatory stimuli. Understanding these responses is critical for developing novel therapeutic agents and vaccine strategies for mucosal diseases.