NFL Charities has awarded UAB a $100,000 grant to study a compound that could minimize the effects of concussions. Known as catalytic oxidoreductant, the compound may interrupt a cascade of biochemical injuries, including oxidative stress and an aggressive immune response to brain inflammation, that cause a large amount of additional cell death after a concussion’s initial damage to brain cells. Candace Floyd, Ph.D., research director in the Department of Physical Medicine and Rehabilitation, and Hubert Tse, Ph.D., an assistant professor in the Department of Microbiology who helped to develop the compound, will lead the research team. Additional studies will examine the compound’s effects on multiple concussions; evidence suggests three or more lead to significant brain damage. The results could point to a drug that could be administered immediately after a concussion, anywhere from sidelines to battlefields.
Winter 2013 UAB Medicine