About Glomerular Disease Therapeutics Laboratory
Our primary goal at the Glomerular Disease Therapeutics Laboratory (GDTL) is to develop novel mechanism based therapy for proteinuria and chronic kidney disease related to glomerular disorders. We use existing animal models, and develop new mechanistically relevant rat models of glomerular disease to study genes and proteins that have potential in future glomerular therapeutics. We also conduct a variety of cell biology, proteomic, molecular biology and imaging studies to rigorously test our hypothesis and develop new agents for treatment of human glomerular disease. Novel therapeutic strategies in advanced stages of development include the use of compounds that alter sialylation in vivo, and various forms of recombinant Angiopoietin-like-4 in the treatment of some forms of nephrotic syndrome (see patents below). We are actively engaged in identifying a circulating glomerulophilic proteome (CGP) that modulates human glomerular disease.
Location: We are physically located on the 6th floor of Tinsley Harrison Tower (rooms 612, 611A, 611B and 611N) in the Division of Nephrology at the University of Alabama at Birmingham.
Patented therapeutic strategies in accelerated development
1) The use of sialic acid precursors in the treatment of glomerular disease and nephrotic syndrome. U. S. patent and PCT have been filed. We welcome communication from parties interested in the licensing or commercialization of this patent.
2) The use of recombinant Angiopoietin-like-4 and its mutants in the treatment of proteinuria, glomerular disease and nephrotic syndrome. In addition to the original PCT, several other patent applications have been filed. We welcome communication from parties interested in the licensing or commercialization of this patent.
Key recent publications
- Clement LC, Macé C, Marshall CM, Del Nogal Avila M, Chugh SS. (2014) The Proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome. Transl Res. pii:S1931-5244 (14). PMID: 25005737
- Macé C, Chugh SS. (2014) Nephrotic syndrome: components, connections and Angiopoietin-like 4 related therapeutics. J Am Soc Nephrol. [Epub ahead of print] PMID:24854282
- Chugh SS, Macé C, Clement LC, Del Nogal Avila M, Marshall C. (2014) Angiopoietin-like 4 based therapeutics for proteinuria and kidney disease. Front Pharmacol. 5:23. PMID:24611049 PDF
- Clement LC*, Macé C* (equal contributors), Avila-Casado C, Joles JA, Kersten S, Chugh SS. (2014) Circulating Angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med. 20(1):37-46. PMID: 24317117 (See commentaries by Vaziri PMID: 24838183 and Kirk PMID:24342959)
- Chugh SS, Clement LC. (2012) Telomerase at the center of collapsing glomerulopathy. Nat Med 18(1):26-27. PMID: 22227662
- Chugh SS, Clement LC, Macé C. (2012) New insights into human minimal change disease: Lessons from animal models. Am J Kid Dis. 59(2):284-292. PMCID: PMC3253318, PMID: 21974967.
- Avila-Casado C, Fortoul TI, Chugh SS. (2011) HIV-associated nephropathy: experimental models. Contrib Nephrol. 169:270-285. PMID: 21252526
- Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S, Chugh SS. (2011) Podocyte – secreted Angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 17(1):117-122. PMCID: PMC3021185, PMID: 21151138
- Clement LC, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C, Chugh SS. (2007) Early changes in gene expression that influence the course of primary glomerular disease. Kidney Int. 72(3):337-347. PMID: 17457373
- Liu G, Clement LC, Kanwar YS, Avila-Casado C, Chugh SS. (2006) ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. J Biol Chem. 281(51):39681-39692. PMID: 17056598
- Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS. (2003) Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest. 112(2):209-221. PMID: 12865409
Funding: NIH / NIDDK
. Phone (205)996-9641. Fax (205)996-9675.
- Sumant S. Chugh MD, Professor of Medicine, Principal Investigator
- Lionel C. Clément PhD, Assistant Professor of Medicine, Investigator
- Camille E. A. Macé PhD, Instructor in Medicine, Investigator
- Caroline Marshall MD, Assistant Professor of Medicine, Investigator
- Mariá Del Nogal Avila, Ph.D., Postdoctoral Fellow
- Hector Donoro Blázquez, Laboratory Assistant