Kim A. Caldwell, Ph.D.


Adjunct Assistant Professor


Primary Department Affiliation
: Biological Sciences

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 205.348.4021
Fax: 205.348.1786

Recent Publications


Curriculum Vitae

KIM A. CALDWELL, Ph.D.

Assistant Professor of Biological Sciences

The University of Alabama

Department of Biological Sciences

P.O. Box 870344

Tuscaloosa, AL 35487-0344

www.bama.ua.edu/~gcaldwel

Education:

SUNY at Fredonia, B.S. in Recombinant Gene Technology (minor in Chemistry), 1987

The University of Tennessee, M.S. in Biotechnology, 1989

The University of Tennessee, Ph.D. in Cell and Molecular Biology, 1995

Professional Experience:

Graduate Teaching Assistant, Dept. of Zoology, University of Tennessee, 1988 - 1991

Graduate Research Assistant, Dept. of Zoology, University of Tennessee, 1991 - 1995

Postdoctoral Research Fellow, Laboratory of Development and Molecular Biology,

The Rockefeller University, 1995 - 1997

Postdoctoral Research Fellow, Dept. Biological Sciences, Columbia University, 1997 - 1999

Biomedical Science Writer, Health Science Communications, Inc., New York, NY, 1999

Adjunct Assistant Professor, Dept. Biological Sciences, University of Alabama, 1999 - 2003

Director, Hughes Rural Science Scholars Program, University of Alabama, 2002 - present

Adjunct Assistant Research Professor, Dept. of Neurology, University of Alabama School of

Medicine, 2003 - present

Faculty member, UA Center for Green Manufacturing, 2003 - present

Assistant Professor, Dept. of Biological Sciences, University of Alabama, 2004 - present

Honors and Awards:

Science Alliance Graduate Student Research Achievement Award, Univ. TN, 1991-1994

Graduate Research Fellowship, Scholarly Activities Research Incentive Fund, Univ. TN, 1994

Chancellor's Award for Extraordinary Professional Promise, Univ. TN, 1994

Blount Undergraduate Initiative Fellow, The University of Alabama, 2002- present

National Academies Summer Institute for Undergraduate Education in Biology participant, 2005

Education Fellow in the Life Sciences, National Academy of Sciences, 2006

Honorary Member, The Anderson Society, 2006

Movement Disorders Society Best Young Investigator Award, Kyoto, Japan, 2006

Member, Omicron Delta Kappa, 2007

Teaching Activities:

1988-1991: University of Tennessee: lecture and laboratory for General Biology I; recitation sessions

for Cell Biology and Genetics; lecture and laboratory for Biotechnology Laboratory

2000 - present: The University of Alabama, Principles of Biology I for majors

2002 - present: The University of Alabama, Decoding Ourselves: The Impact of the Human Genome

Project on Science & Society

2003 - 2006: The University of Alabama, The Language of Research

University Administrative Activities:

2000 - 2006: Director, Rural Science Scholars Program at The Univ. of Alabama

2004 - 2006: Biological Sciences Department Graduate Student Committee, UA

Direction of Graduate Student Research:

2001. Michael Shiffler. Protein-protein interaction screening for NUD-1 interactors. M.S., UA

2002. Elaina Sexton. Suppression of polyglutamine-induced protein aggregation in Caenorhabditisby torsin proteins. M.S., UA

elegans

2003. Christopher Gelwix. Torsin-mediated protection from cellular stress in the dopaminergic

neurons of C. elegans. M.S., UA

2005. Summer Slater. Functional analysis of structural alterations of nud-1during embryonic cell

divisions in C. elegans. M.S., UA

2006. Shelli Williams. Functional Characterization of The Roles of Lissencephaly-Related Proteins In

Cellular Division And Neuronal Synchrony. Ph.D., UA

2006. Songsong Cao. Functional characterization of torsins in C. elegans models of

human neurological movement disorders. Ph.D., UA

2003-present. Shusei Hamamichi. Identification of new Parkinson's disease genes.

2005-present. Jafa Armagost. Bacterial causes of Parkinson's disease.

2006-present. Pan Chen. Role of torsinA in movement disorders.

2006-present. Bwarenaba Kautu. Identification of new epilepsy-associated genes.

2006-present. Adam Harrington. Identification of new torsinA associated proteins.

2006-present. Michelle Tucci. Behavioral analysis of C. elegans with dopamine neuron death.

2006-present. Alexander Burdette. Chemical-genetic analysis of torsinA function.

Direction of Undergraduate Research:

2000-2001. John Paul Bevel. Cloning of torsin proteins into expression vectors.

2001-2001. Clay Blanton. Isolation of the cDNA for TOR-2.

2001-2002. Jenny Whitworth. Analysis of nuclear migration genes during embryonic cell division.

2001-2003. Sarah Adair. RNAi screening for new Parkinson's related genes.

2002-2003. Meiklejohn McKenzie. Genetic screening for NUD-1 effectors.

2002-2002. Sarah Howard. Protein-protein interaction screening for TOR-2 effectors.

2002-2003. Daniel Wyatt. Protein-protein interaction screening for TOR-2 effectors.

2002-2004. Mathew Cybulsky. Protein-protein interaction screening for NUD-1 effectors.

2002-2003. Andrea Braden. Induction of epileptic-like convulsions in C. elegans.

2003-2004. Perry Guevara. RNAi screening for new Parkinson's related genes.

2003-2004. Stephanie Brennan. RNAi screening for new Parkinson's related genes.

2003-2005. Kimberly Peters. Cell division analysis of potential NUD-1 interactors.

2003-2006. Cody Locke. Analysis of potential epilepsy-associated genes in C. elegans.

2005-2006. Meaghan Till. Cell division analysis of potential NUD-1 interactors.

2004-2006. Shermeen Memon. Analysis of the potential toxic effects of ionic liquids in C. elegans.

2004-2006. Amber Clark. Compound screening for potential therapeutic intervention for dystonia.

2004-2006. John Philips. Investigating the relationship between NUD-1 and γ-tubulin.

2005-2007. Robyn Thomas. Cell division analysis of potential NUD-1 interactors.

2006-2007. Alicia Wright. Cell division analysis of NUD-1 associated proteins.

2004-present. Renee Rivas. Functional relationship between two proteins implicated in dystonia.

2005-present. Jeana Blalock. Environmental causes of Parkinson's disease.

2005-present. Ashley Phares. Tauopathy in C. elegans.

2005-present. Stacey Fox. The effect of Tylenol on polyglutamine disease models.

2005-present. Adam Knight. Identification of proteins that interact with LRRK2.

2006-present. Kyle Lee. Identification of new epilepsy-associated genes.

2006-present. John Ricketts. Identification of Parkinson's disease -related genes.

2006-present. Max Thompson. Identification of Parkinson's disease -related genes.

2006-present. Susan Deleon. Environmental causes of Parkinson's disease.

2006-present. Lauren Bryant. Dopamine associated behavioral analysis of C. elegans.

2006-present. Kalen Berry. Computer-aided analysis of C. elegans movement.

Research Grants:

Charles H. Revson Foundation

• "Investigations of Wingless Signal Transduction in Drosophila melanogaster"

• $30,000; 1995-1996

• Postdoctoral Fellow

National Institute of Child Health and Human Development

• "Investigations of Wingless Signal Transduction in Drosophila melanogaster"

• $75,000; 1996-1999

• NRSA Postdoctoral Fellowship

Bachmann-Strauss Dystonia & Parkinson Foundation

• "Analysis of torsin-mediated protection from cellular stress in C. elegans"

• $50,000; January 2004-December 2004

• Co-PI with Dr. Guy Caldwell, UA

Dystonia Medical Research Foundation

• " Chemical Screening for Torsin Effectors in C. elegans"

• $39,000; January 2005-December 2005

• Co-PI with Dr. Guy Caldwell, UA

Bachmann-Strauss Dystonia & Parkinson Foundation

• "Proteomic Analysis of Torsin Effectors and Functional Interactions Pertaining to Dystonia"

• $50,000; January 2005-December 2005

• Co-PI with Dr. Guy Caldwell, UA

The University of Alabama Research Advisory Committee

• "Functional Characterization of NUD-1: A Novel Regulator of Cell Division"

• $5,000; May 2005-April 2007

• PI

The University of Alabama College of Arts and Sciences Teaching Grants

• "Active Learning in Large Lecture Classrooms"

• $2,000; May 2005-April 2006

• PI

McNeil Consumer and Specialty Pharmaceuticals

• "Functional Survey of the Neuroprotective Benefits of Tylenol for Movement Disorders"

• $75,000; January 2006-December 2006

• PI

Bachmann-Strauss Dystonia & Parkinson Foundation

• "Examining the Neuroprotective Capacity of Novel Gene Targets Associated with Parkinson's

Disease"

• $50,000; January 2006-December 2006

• Co-PI with Dr. Guy Caldwell, UA

National Institutes of Health

• "Investigation of C. elegans NUD-1 in Centrosome Function and Mitosis"

• $211,000; April 2006-March 2008

• PI

The Parkinson's Institute, contract award

• "STOP-PD Initiative: A Project to Identify a Compound that will Stop, and Ideally, Reverse

Parkinson's Disease"

• $100,000; January 2006-December 2006

• Co-PI with Dr. Guy Caldwell, UA

FoldRx Pharmaceuticals, Inc.

• "Investigation of compounds as neuroprotective agents in C. elegans model of PD"

• $40,000 for July 2006 - September 2006

• Co-PI with Dr. Guy Caldwell, UA

Bachmann-Strauss Dystonia & Parkinson Foundation

• "Investigating small molecule therapeutics for torsion dystonia"

• $50,000; January 2007-December 2007

• Co-PI with Dr. Guy Caldwell, UA

Michael J. Fox Foundation for Parkinson's Research

• "Validation of VPS41, A protein involved in lysosomal trafficking, as a new target for

Parkinson disease therapy"

• $250,000; May 2007-April 2009

• Co-PI with Drs. David Standaert (UAB) and Guy Caldwell (UA)

National Parkinson Foundation

• "Examining the neuroprotective capacity of gene targets associated with Parkinson's disease"

• $40,000; June 2007-May 2008 (declined)

• PI

Publications

:

Textbook

 

Caldwell, G.A., Williams, S.N., and Caldwell, K.A. 2006. Integrated Genomics: A DiscoverybasedWiley, Chichester, UK.

Laboratory Course.

Book Chapters

 

Handel, M.A., Shannon, M., and Caldwell, K.A. (1993) "Sex chromosome activity during meiosis."

In: Meiosis II: Contemporary Approaches to the Study of Meiosis (ed., Haseltine, F.P., and

Heyner, S.), AAAS pp. 55-68.

Caldwell, G.A., Cao, S., Gelwix, C.C., Sexton, E.G., and Caldwell, K.A. (2004) "An Animal Model

to Discern Torsin Function: Suppression of Protein Aggregation in C. elegans" In Advances in(Fahn, S., Marsden, D., and DeLong, M., eds). Lippencott, Williams &

Neurology: Dystonia 4

Wilkens, New York, 94:79-85.

Caldwell, G.A., Cao, S., Izevbaye, I., and Caldwell, K.A. (2005) "Use of C. elegans to Model

Human Movement Disorders" In Animal Models of Movement Disordes (LeDoux, J., ed.) Elsevier,

New York, 111-126.

Baumeister, R., Samann, J., Caldwell, K.A., and Caldwell, G.A. "Alzheimer's and Parkinson's

Disease". WormBook: in revision

Research Publications

Caldwell, K.A.,

and Handel, M.A. (1991) "Protamine transcript sharing among

postmeiotic spermatids." Proc. Natl. Acad. Sci. USA 88:2407-2411.

Handel, M.A., Caldwell, K.A., and Wiltshire, T. (1995) "Culture of pachytene

spermatocytes for analysis of meiosis." Developmental Genetics 16:128-139.

Wiltshire, T., Park, C., Caldwell, K.A., and Handel, M.A. (1995) "Induced premature

G2/M transition in pachytene spermatocytes includes events unique to meiosis."

 

Developmental Biology

169:557-567.

Caldwell, K.A.,

Wiltshire, T., and Handel, M.A. (1996) "A genetic strategy for

differential screening of meiotic germ-cell cDNA libraries." Molecular Reproduction43:403-413.

and Development

Matunis, E., Tran, J., Gonczy, P., Caldwell, K.A., and Dinardo, S. (1997) "punt and

schnurri

regulate a somatically derived signal that restricts proliferation of committed

progenitors in the germline." Development 124:4383-4391.

Jong, M.T.C., Carey, A.H., Caldwell, K.A., Handel, M.A., Driscoll, D.J., Stewart, C.L.,

Rinchik, E.M., and Nicholls, R.D. (1999) "Imprinting of a RING zinc-finger encoded

gene in the mouse chromosome region homologous to Prader-Willi syndrome."

 

Human Molecular Genetics

8:795-803.

Wehrli, M., Dougan, S., Caldwell, K., Schwartz, S., O'Keefe, L., Vaizel-Ohayon, D., Schejter, E.,

Tomlinson, A., and DiNardo, S. (2000) "Arrow encodes a LDL Receptor-Related Protein Essential

for Wingless Signaling." Nature 407:527-530.

Dawe, A. L., Caldwell, K.A., Harris, P.M., Morris, N.R., and Caldwell, G.A. (2001).Evolutionarily conserved nuclear migration genes required for early embryonic

"

development in Caenorhabditis elegans." Develop. Genes Evol211:434-441..

Caldwell GA, Cao S, Sexton EG, Gelwix CC, Bevel JP, Caldwell KA. (2003).

"Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans

by torsin proteins." Human Molecular Genetics 12:307-319.

Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A., Lin, S-H.,

Yu-Lee, L. (2003) "A Role for NudC, a Dynein-Associated Nuclear Movement Protein, in mitosis

and Cytokinesis" J. Cell Science 116:1991-2003.

Swatloski, R.P., Holbrey, J.D., Memon, S. B., Caldwell, G.A., Caldwell, K.A., and Rogers, R.D.

(2004) "Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride

based ionic liquids. Chem. Commun. 6:668-669.

Williams, S.N., Braden, A.L., Locke, C., Caldwell, K.A., and Caldwell, G.A. (2004) "Epileptic-like

convulsions associated with LIS1 in the cytoskeletal control of neurotransmitter signaling in C.." Human Molecular Genetics 13:2043-2059.

elegans

Locke, C.J., Caldwell, K.A., and Caldwell, G.A. (2005) "CarpeDB: A comprehensive database on the

genetics of epilepsy" Nucleic Acids Res. 33:D5-24.

Cao, S., Gelwix, C.C., Caldwell, K.A., and Caldwell, G.A. (2005) "Torsin-mediated

protection from cellular stress in the dopaminergic neurons of C. elegans." Journal of25:3801-3812.

Neuroscience

Dickey, C.A., Dickson, D., Yue, M., Lin, W-L., Dunmore, J., West, G., Patterson, C., Cao, S., Clark,

A.K., Caldwell, G.A., Caldwell, K.A., Eckman, C., Hutton, M., and Petrucelli, L. (2006) "Deletion

of CHIP leads to caspase-3 activation and neuronal apoptosis associated with increases in nonubiquitinated,

soluble phospho-tau species without neurofibrilary tangles. Journal of Neuroscience

26:6985-6996

Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K., Xu, K.,

Strathearn, K.E., Liu, F., Cao, S., Caldwell, K.A., Caldwell, G.A., Marsischky, G., Kolodner, R.D.,

Labaer, J., Rochet, J.C., Bonini, N.M., and Lindquist, S. (2006) "alpha-synuclein blocks ER-golgi

traffic and Rab1 rescues neuron loss in Parkinson's models" Science 313:324-328.

Locke, C.J., Williams, S.N., Schwarz, E.M., Caldwell, G.A., and Caldwell, K.A. (2006) "Genetic

Interactions Among Cortical Malformation Genes that Influence Susceptibility to Convulsions"

 

Brain Research

1120:23-34.

Patents Pending

 

Caldwell, G.A. and Caldwell, K.A. "Nucleotide Sequences that Code for Torsin Genes, Torsin

Proteins, and Methods of Using the Same to Treat Protein-Aggregation" Patent Awarded by the

U.S. Patent and Trademark Office, #224040US23; Nov. 2005

Caldwell, G.A. and Caldwell, K.A. "Regulators of Protein Misfolding and Aggregation and Methods

of Using the Same" Patent Application to the U.S. Patent and Trademark Office, February 2005

Caldwell, G.A. ,Caldwell, K.A., Cao, S. "Methods of using small molecule compounds for protein

aggregation" Patent Application to the U.S. Patent and Trademark Office, November 2005

Caldwell, G.A. ,Caldwell, K.A., Cao, S. "Methods of using small molecule compounds for

neuroprotection" Patent Application to the U.S. Patent and Trademark Office, December 2005

Invited Seminars:

• Baylor College of Medicine, Houston, TX. May, 2001

• The University of Alabama at Huntsville, Huntsville, AL. October 2001

• AED Premedical Honor Society, UA, Tuscaloosa, AL. November 2003

• Bachmann-Strauss Dystonia & Parkinson Foundation Think Tank, New York, NY. Nov. 2003

• UA Parker Adams Program, Tuscaloosa, AL. January 2004

• Dystonia Medical Research Foundation Grant Holders Workshop, Atlanta, GA. February 2004

• UA Neuropsychology graduate seminar, Tuscaloosa, AL. February 2004

• The University of Wisconsin - La Crosse, La Crosse, WI. March 2004

• The University of Louisiana at Monroe, Monroe, LA. March 2004

• The University of Idaho, Moscow, ID. April 2004

• UAB Medical School, Neurology Grand Rounds, Birmingham, AL. May 2004

• UA Touch of Class seminar, Tuscaloosa, AL. October 2004

• The University of Montevallo, Montevallo, AL. November 2004

• UA Chemical Engineering Honors Forum, Tuscaloosa, AL. December 2004

• UAB Medical School, Gene Therapy Center, Birmingham, AL. February 2005

• UA Library Seminar Series, Tuscaloosa, AL. February 2005

• McCollough Medical Scholars Forum, Tuscaloosa, AL. February 2005

• UA Chemical Engineering Honors Forum, Tuscaloosa, AL. March 2005

• UA Center for Mental Health and Aging, Tuscaloosa, AL. March 2005

• MD Anderson Cancer Center, Houston, TX. March 2005

• Baylor College of Medicine, Houston, TX. March 2005

• UA Lifelong Learning Seminar, Tuscaloosa, AL. April 2005

• Mississippi State University, Starkville, MS. April 2005

• The University of Wisconsin - Madison, Madison, WI. August 2005

• Bachmann Strauss Dystonia and Parkinson's Disease Think Tank, New York, NY. Nov. 2005

• Dystonia Medical Research Foundation Grantholders Workshop - Scottsdale, AR. Feb. 2006

• Dystonia Workshop at The National Institutes of Health, Bethesda, MD. June 2006

• International Movement Disorder Society Congress, Kyoto, Japan. November 2006

• UAB Departments of Neurobiology and Biochemistry, Birmingham, AL. November 2006

• Partnership for Biotechnology Research, Huntsville, AL. February 2007

• UA Library Seminar Series, Tuscaloosa, AL. February 2007

• The University of Tennessee, Knoxville, TN. March 2007

• Pennington Biomedical Research Center at LSU, Baton Rouge, LA. March 2007

• Explorations in Lifelong Learning Seminar, Tuscaloosa, AL. April 2007

• The University of Ottawa, Health Research Institute, Ottawa, Canada. May 2007

• Department of Neurology, Universität Tübingen, Tübingen, Germany. July 2007