Rosalinda Roberts

Primary Department Affiliation: Psychiatry and Behavioral Neurobiology

Sparks Center, 866B
1720 7th Ave. South
Birmingham, Al 35294
Sparks Center, 865D

Education:
- 1979-1982 B.S., Biological Sciences, University of California, Irvine

- 1982-1986 Ph.D., Biological Sciences, Department of Anatomy and Neurobiology, University of California, Irvine, California

- 1986-1989 Postdoctoral Fellow, Department of Neurology, Harvard Medical School and Massachusetts General Hospital Boston, Massachusetts

Academic Appointments with UAB:
- Kathy Ireland Professor, Department of Psychiatry and Behavioral Neurobiology
- Professor of Neurobiology (secondary)
- Professor of Cell Biology (secondary)
- Senior Scientist, Civitan International Research Center

Previous Academic Appointments:
- 1989-1990 Instructor in Neurology, Department of Neurology, Harvard Medical School and Massachusetts General Hospital Boston, Massachusetts

- 1990-2007 Faculty, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Maryland

- Emma Perez-Costas, PhD, Assistant Professor - This email address is being protected from spambots. You need JavaScript enabled to view it.

Research Interests:
- Basal Ganglia Neurobiology in Normal and Diseased Brain
- Neuropathology in Schizophrenia and other mental illnesses
- Antipsychotic Drug Effects
- Development of the mammalian striatum
- Developing and maintaining postmortem psychiatric brain collections

Recent Publications:
Roberts, R.C., Xu, L., Roche, J.K., and Kirkpatrick, B. (2005) The ultrastructural localization of reelin in the cortex in postmortem human brain. J. Comp. Neurol., 482:294-308.

Roberts, R.C., Roche, J.K., and Conley, R.R. (2005) Synaptic differences in the postmortem striatum of subjects with schizophrenia: a stereological ultrastructural analysis. Synapse, 56:185-197.

Hutcherson, L. and Roberts, R.C. (2005) The immunocytochemical localization of substance P in the human striatum: a postmortem ultrastructural study. Synapse, 57:191-201.

Akbarian, S., Ruehl, M.G., Bliven, E., Luiz, L.A., Peranelli, A.C., Baker, S.P., Roberts, R.C., Bunney Jr., W.E., Conley, R.C., Jones, E.G., Tamminga, C.A., and Guo, Y. (2005) Chromatin alterations associated with downregulated metabolic gene expression in prefrontal cortex of schizophrenics. Arch. Gen. Psych., 62:829-840.

Roberts, R.C., Roche, J.K., and Conley, R.R. (2005) Synaptic differences in the patch matrix compartments of the striatum of subjects with schizophrenia: a postmortem ultrastructural analysis. Neurobiol. Dis., 20:324-335.

Kirkpatrick, B., Xu, L., Cascella, N., Ozeki, Y., Sawa, A., and Roberts, R.C. (2006) DISC1 immunoreactivity at the light and ultrastructural level in the human neucortex.. Jrl. Comp. Neurol., 497:436-450.

Roberts, R.C. (2007) Disrupted in Schizophrenia (DISC1): Integrating clinical and basic findings. Schizophr Bull. 33 (1):11-5.

Dwivedi,Y., Rizavi, H.S., Teppen, T., Sasaki, N., Chen, H., Zhang, H., Roberts, R.C., Conley, R.R., and Pandey, G.N. (2007) Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects. Neuropsychopharmacology, 32:2338-2350.

Poeggeler, B., Rassoulpour, A., Wu, H.W., Guidetti, P., Roberts, R.C., and Schwarcz, R. (2007) Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal NMDA neurotoxicity. Neurosci., 148(1):188-97.

Perez-Costas, E., Melendez-Ferro, M., and Roberts, R.C. (2007) Microscopy techniques and the study of synapses. In: Modern Research and Educational Topics in Microscopy. A. Mendez-Vilas and J. Diaz (eds), Formatex, Badajoz, Spain, Vol 1:164-170.

Perez-Costas, E., Guidetti, P., Melendez-Ferro, M., Kelley, J.J., and Roberts, R.C. (2008) Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assays. J. Neural Transm. May;115(5):745-53

Roberts, R.C., and Perez-Costas, E. (2008) Ultrastructural localization of reelin, In: Reelin glycoprotein. Structure, biology and roles in health disease. S.H. Fatemi (ed.), Springer, May, 8:107-126.

Roberts, R.C., Roche, J.K., and Conley, R.R. (2008) Differential synaptic changes in the striatum of subjects with undifferentiated vs. paranoid schizophrenia. Synapse, Aug 62(8):616-27.

Pandey, G.N., Ren, X., Rizavi, H.S., Conley, R.R., Roberts, R.C., Dwivedi, Y. (2008) Brain-derived neurotrophic factor and tyrosine kinase B receptor signaling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol. ( 2008) Jul 9:1-15.

Wonodi, I, Hong, L.E., Stine, O.C., Mitchell, B.D., Elliott, A., Roberts, R.C., Conley, R.R., McMahon, R.P., and Thaker, G.K. (2008) Dopamine Transporter Polymorphism Modulates Oculomotor Function and DAT1 mRNA Expression in Schizophrenia, Am J Med Gen, in press.

Melendez-Ferro M, Perez-Costas, E., Roberts, R.C. (2008) A new use for long term frozen brain tissue: Golgi impregnation. J. Neuroscience Methods, in press.

Roberts, R.C., Roche, J.K., Conley, R.R., and Lahti, A. (2008) Dopaminergic synapses in the caudate nucleus of subjects with schizophrenia: relationship to treatment response. Synapse, in press.