Guy Caldwell, Ph.D.
Adjunct Assistant Professor
Primary Department Affiliation: Biological Sciences
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Recent Publications
Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page
BIOGRAPHICAL SKETCH
NAME
Guy Alexander Caldwell
eRA COMMONS USER NAME
guycaldwell
POSITION TITLE
Associate Professor of Biological Sciences
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
Washington & Lee University Lexington, VA B.S. 1981-1986 Biology
The University of Tennessee Knoxville, TN Ph.D. 1986-1993 Cell & Molecular Biology
Columbia University New York, NY Postdoctoral 1995-1999 Neurogenetics
A. Positions and Honors
Positions Held
1985-1986 Research Assistant, Department of Biology, Washington & Lee University
1986-1987 Research Intern in Molecular Genetics, Burroughs-Wellcome Co., Research Triangle Park, NC
1987-1990 Graduate Teaching Assistant, Dept. Microbiology, The University of Tennessee
1990-1993 Graduate Research Assistant, Dept. Microbiology, The University of Tennessee
1995-1996 Lecturer, Cell Biology, The University of Tennessee
1995-1999 Postdoctoral Research Fellow, Columbia University, Sponsor: Martin Chalfie
1999-2005 Assistant Professor of Biological Sciences, The University of Alabama
2003- Faculty Affiliate, Center for Mental Health & Aging, The University of Alabama
2003- Faculty Member, Center for Green Manufacturing, The University of Alabama
2004- Adjunct Research Asst. Professor, Dept. Neurology, Univ. Alabama at Birmingham (UAB)
2005- Associate Professor of Biological Sciences, The University of Alabama
2007- Scientist, Center for Experimental Therapeutics and Neurodegeneration, UAB
2007- Adjunct Associate Professor, Dept. Neurobiology, UAB
Honors
1983-1986 Robert E. Lee Research Scholarship, Washington & Lee University
1988-1993 Science Alliance Research Achievement Award, Oak Ridge National Lab - U. Tennessee
1992 American Society for Cell Biology Student Travel Award
1995-1998 NRSA Postdoctoral Fellowship, NINDS, 1st percentile rank
2001-2003 Basil O'Connor Scholar of The March of Dimes Birth Defects Foundation
2003- CAREER Award Recipient, National Science Foundation
2005- Leadership Board Fellow, The University of Alabama, College of Arts & Sciences
2005 Howard Hughes Medical Institute Investigator, Nominee
2005 Carnegie Foundation and CASE U.S. Professor of The Year, State of Alabama
Memberships
American Society for Cell Biology
American Association for the Advancement of Science
American Epilepsy Society
International Brain Research Organization
Movement Disorders Society
Society for Neuroscience
Genetics Society of America
B. Selected publications
Textbooks Authored
Becker, J. M., Caldwell, G.A., and Zachgo, E. A. (1990) Biotechnology: A Laboratory Course. Academic Press, Inc.
Harcourt Brace Jovanovich Publishers), San Diego (textbook, 232 pages) [Chinese edition also]
Becker, J.M., Caldwell, G.A., and Zachgo, E.A. (1996) Biotechnology: A Laboratory Course, 2nd Edition. Academic
Press, Inc. (Harcourt Brace Publishers), San Diego (textbook, 250 pages) [Spanish edition also]
Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page
Caldwell, G.A., Williams, S.N., and Caldwell, K.A. (2006) Integrated Genomics: A Discovery-based Laboratory
Course. (Wiley), Chichester, U.K. (textbook, 225 pages)
Book Chapters
Caldwell, G.A., Cao, S., Izevbaye, I., and Caldwell, K.A. (2005) "Use of C. elegans to Model Human Movement Disorders"
In Animal Models of Movement Disorders (LeDoux, M., ed.) Elsevier, New York, pp. 113-128
Baumeister, R., Säman, J., Caldwell, K.A., and Caldwell, G.A. (2007) "Investigating Alzheimer's and Parkinson's Disease
using C. elegans" In Wormbook (Chalfie, M., ed.). in press
Journal Articles
Marcus, S., Caldwell, G.A., Xue, C.-B., Naider, F. and Becker, J.M. (1990) "Total in vitro Maturation of the S. cerevisiae
a-factor Lipopeptide Mating Pheromone". Biochem. Biophys. Res. Comm. 172:1310-1316.
Marcus, S., Caldwell, G.A., Miller, D., Xue, C.-B., Naider, F., and Becker, J.M. (1991) "Significance of C-terminal
Cysteine Modifications to the Biological Activity of Saccharomyces cerevisiae a-factor Mating Pheromone". Mol. Cell.
Biol. 11:3603-3612.
Caldwell, G.A., Wang, S-H., Dawe, A.L., Becker, J.M. and Naider, F. (1993) "Identification of a Hyperactive Mating
Pheromone of Saccharomyces cerevisiae". Biochem. Biophys. Res. Comm. 197:1173-1178.
Ben-Yaacov, R., Knoller, S., Caldwell, G.A., Becker, J., and Koltin, Y. (1994) "Candida albicans Gene Encoding
Resistance to Benomyl and Methotrexate is a Multidrug Resistance Gene". Antimicrob. Agents Chemother.
38:648-652.
Caldwell, G.A., Wang, S.-H., Lu, H.-F., Naider, F., and Becker, J.M. (1994) "Molecular Determinants of the Bioactivity of
the Saccharomyces cerevisiae Lipopeptide Mating Pheromone". J. Biol. Chem. 269:19817-19826.
Caldwell, G.A., Wang, S.-H., Naider, F., and Becker, J.M. (1994) "Consequences of Altered Isoprenylation Targets on afactor
Export and Bioactivity". Proc. Natl. Acad. Sci. USA. 91:1275-1279.
Caldwell, G.A., Naider, F. and Becker, J.M. (1995) "Fungal Lipopeptide Mating Pheromones: A Model System for the
Study of Protein Prenylation" Microbiol. Rev. 59:406-422.
Gu, G., Caldwell, G.A., and Chalfie, M. (1996) "Genetic Interactions Affecting Mechanosensation in C. elegans."
Proc. Natl. Acad. Sci. USA. 13:6577-6582.
Dawe, A. L., Caldwell, K.A., Harris, P.M., Morris, N.R., and Caldwell, G.A. (2001) "Evolutionarily conserved nucelar
migration genes required for early embryonic development in C. elegans". Dev. Genes Evol. 211:434-441.
Caldwell G.A., Cao S., Sexton E.G., Gelwix C.C., Bevel J.P., and Caldwell K.A. (2003) "Suppression of polyglutamineinduced
protein aggregation in Caenorhabditis elegans by torsin proteins." Hum. Mol. Genet. 12:307-319.
Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A., Lin, S-H., Yu-Lee, L. (2003) "A Role for
NudC, a Dynein-Associated Nuclear Movement Protein, in Mitosis and Cytokinesis" J. Cell Sci. 116:1991-2003.
Swatloski, R.P. Rogers, R.D., Holbrey, J.D., Turner, M.B., Memon, S.B. Caldwell, G.A. and Caldwell, K.A., (2004) "Using C.
elegans to Probe Toxicity of 1-alkyl-3-methylimidazolium Chloride Based Ionic Liquids" Chem. Comm. 6:689-690.
Caldwell, G.A., Cao, S., Gelwix, C.C., Sexton, E.G., and Caldwell, K.A. (2004) "An Animal Model to Discern Torsin Function:
Suppression of Protein Aggregation in C. elegans" Adv. Neurol. 94:79-85.
Williams, S.N., Locke, C.J., Braden, A.L., Caldwell, K.A., and Caldwell, G.A. (2004) "Epileptic-like convulsions associated
with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans" Hum. Mol. Genet.
13:2043-2059.
Zhang, S., Keller, C.A., Yao, C. A., Caldwell, G.A.,Chalfie, M. (2004) "MEC-2 is recruited to the putative mechanosensory
complex in C. elegans touch receptor neurons through its stomatin-like domain," Curr. Biol.14:1888-1896.
Cao S., Gelwix C.C., Caldwell K.A. and Caldwell G.A. (2005) "Torsin-mediated protection from cellular stress in the
dopaminergic neurons of C. elegans" J. Neurosci. 25:3801-12.
Dickey, C.A., Dickson, D., Yue, M., Lin, W-L., Dunmore, J., West, G., Patterson, C., Cao, S., Clark, A.M.K., Caldwell,
G.A., Caldwell, K.A., Eckman, C., Hutton, M., and Petrucelli, L. (2005) "Deletion of CHIP leads to caspase-3 activation
and neuronal apoptosis associated with increases in non-ubiquitinated, soluble phospho-tau species without
neurofibrilary tangles. J. Neurosci. 26:6985-6996.
Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K., Xu, K., Strathearn, K.E., Liu, F., Cao,
S., Caldwell, K.A., Caldwell, G.A., Kolodner, R.D., Marsischky, G., LaBaer, J., Rochet, J-C., Bonini, N.M., and
Lindquist, S. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 Rescues Neuron Loss in Parkinson's Models.
Science, 313:324-328.
Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page
Locke, C.J., Williams, S.N., Schwarz, E.M., Caldwell, G.A., and Caldwell, K.A. (2006) "Genetic Interactions Among
Cortical Malformation Genes that Influence Susceptibility to Convulsions" Brain Research, 1120:23-34.
C. Research Support
ACTIVE
No number specified (G. Caldwell and K. Caldwell) 1/1/2007-12/31/2007
Bachmann-Strauss Dystonia & Parkinson Foundation
Identification Chemical Modifiers of Torsin Activity
The major goals of this study are aimed at identifying new chemical modifiers of torsinA activity using C. elegans. Positive
hits will be shared with researchers at The Broad Institute and Harvard to study potential binding to torsinA and efficacy of
specific hits in dystonia patient fibroblasts.
Role: Co-Principal Investigator
No Number Specified (G. Caldwell and K. Caldwell) 1/1/2007-8/31/2007
FoldRx Pharmaceuticals
Small Molecule Testing for Neuroprotective Compounds Associated with Parkinson's Disease
The major goals of this study are aimed at investigating the potential of specific small molecule modifiers of alphasynuclein
neurodegeneration in C. elegans.
Role: Co-Principal Investigator
237956 (G. Caldwell) 7/1/2003- 6/30/2008
NSF/CAREER Award
CAREER: An Integrated Discovery-Based Genomic Approach to Discerning the Role of Nuclear Positioning Genes in
Neurodevelopment
This represents a combination teaching/research grant designed to support young faculty who design career plans that
integrate research into innovative curricula. The research aspects of this award focus on gene products associated with
cytoskeletal control of nuclear migration and its impact on neurodevelopment.
1R21ES014426-01 (G. Caldwell) 1/1/2006-12/31/2007
NIH/NIEHS
Use of C. elegans to Explore Bacterial Sources of Toxicity in Parkinson's Disease
The major goals of this exploratory project are to investigate the prospect of bacterial sources of neurotoxins that may
contribute to the development of Parkinson's disease.
Role: Principal Investigator
No number specified (D.G. Standaert, K. Caldwell, and G. Caldwell) 07/01/2007-06/30/2009
Michael J. Fox Foundation for Parkinson's Research
Validation of VPS41, a protein involved in lysosomal trafficking, as a target for Parkinson disease therapy
This collaborative investigation with Dr. David Standaert at UAB involves target validation in mouse and cell culture
models of a gene that we have identified as being neuroprotective against dopaminergic neurodegenration induced by
overexpression of human alpha-synuclein in C. elegans.
Role: Co-Principal Investigator
No number specified (G. Caldwell) 07/01/2007-06/30/2008
American Parkinson Disease Association
Identification and Functional Validation of Neuroprotective Genes Associated with Parkinson's Disease
The major goals of this study are aimed at investigating the potential for specific genes we have previously identified as
affecting human alpha-synuclein misfolding and their capacity for functioning as neuroprotective proteins in dopamine
neurons.
Role: Principal Investigator
OVERLAP
There is no overlap between this NIH grant submission and any of the pending support listed above.
Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page
COMPLETED (past 3 years)
No number specified (G. Caldwell and K. Caldwell) 1/1/2006-12/31/2006
Bachmann-Strauss Dystonia & Parkinson Foundation
Examining the Neuroprotective Capacity of Novel Gene Targets Associated with Parkinson's Disease
The major goals of this project were to validate gene targets isolated from RNAi screening for genetic effectors of alphasynuclein
misfolding. This work identified 4 neuroprotective genes previously unassociated with Parkinson's.
Role: Co-Principal Investigator
No number specified (G. Caldwell and K. Caldwell) 3/1/2006-02/28/2007
The Parkinson's Institute
STOP-PD Program
This contract represented a collaboration between our lab and those of chemist, Dr. Anthony Fink (UC-Santa Cruz), and
neurologist, Dr. J. William Langston (Director, The Parkinson's Institute), with whom we have formed a new drug
screening "pipeline" (from test tubes to worms to rodents to primates to human clinical trials) for small molecule
therapeutics designed to protect dopamine neurons from toxic expression of human alpha-synuclein. This project is
currently on hold as development of mouse and primate models continues.
Role: Co-Principal Investigator
0403081 (G. Caldwell, J. O'Donnell, E. Stephenson) 1/1/2005-12/31/2006
NSF/Multi-user Equipment Grant
Confocal Microscopes for The University of Alabama Optical Analysis Facility
This was an equipment grant funded to purchase a new confocal microscope.
Role: Co-Principal Investigator
0500766 (G. Caldwell, H. Smith-Somerville, M. Powell) 06/01/2005-05/31/07
NSF/Multi-user Instrumentation Grant
Transmission Electron Microscopy for The University of Alabama Optical Analysis Facility
This was an equipment grant designed to upgrade an older existing TEM device in our department.
Role: Co-Principal Investigator
No number specified (G. Caldwell and K. Caldwell) 1/1/2005-12/31/2005
Dystonia Medical Research Foundation
Chemical screening for torsin effectors in C. elegans
The major goals of this project were to perform a medium throughput small molecule screen for compounds that affect the
activity of torsin proteins, as they malfunction in a nematode model of early-onset dystonia. One of these molecules is
now going to human clinical trials.
Role: Co-Principal Investigator
No number specified (G. Caldwell and K. Caldwell) 1/1/2005-12/31/2005
Bachmann-Strauss Dystonia & Parkinson Foundation
Proteomic Analysis of Torsin Effectors & Functional Interactions Pertaining to Dystonia
The major goals of this project were to identify effectors of torsin-related proteins using proteomic methods. This work
was also aimed at probing the potential molecular relationships between different forms of dystonia.
Role: Co-Principal Investigator
No number specified (G. Caldwell) 01/01/03-12/31/2004
Michael J. Fox Foundation for Parkinson's Research
RNAi Screening and Analysis of Factors Influencing ER-Associated Degradation and Alpha-Synuclein Aggregation in C.
elegans.
This grant funded a combination of bioinformatics/genomic-scale RNAi screening approach toward discerning novel
genetic susceptibility factors and therapeutic targets for Parkinson's disease.
Role: Principal Investigator
1 R15 NS043176 (G. Caldwell) 2/1/2003-7/31/2006
NIH/NINDS
This AREA grant supported initial studies into the function of the torsin family of proteins and their relationship to earlyonset
torsion dystonia, a human movement disorders. These studies established C. elegans as a model system wherein
torsin activity could be evaluated.
Role: Principal Investigator
GUY A. CALDWELL, Ph.D.
Associate Professor of Biological Sciences
The University of Alabama
Department of Biological Sciences
P.O. Box 870344
Tuscaloosa, AL 35487-0344
www.bama.ua.edu/~gcaldwel
Education:
Washington and Lee University, B.S. in Biology, 1986 (cum laude)
The University of Tennessee, Ph.D. in Cell and Molecular Biology, 1993; Jeffery Becker, mentor
Columbia University, Postdoctoral Fellow, 1995-1999; Martin Chalfie, sponsor
Professional Experience:
Graduate Teaching Assistant, Dept. of Microbiology, University of Tennessee, 1987-1990
Graduate Research Assistant, Dept. of Microbiology, University of Tennessee, 1990-1993
Postdoctoral Research Scientist, University of Tennessee, 1994, Jeffrey Becker, sponsor
Postdoctoral Research Fellow, Columbia University, 1995-1999; Martin Chalfie, sponsor
Assistant Professor, Dept. Biological Sciences, The University of Alabama, 1999-2005
Faculty Affiliate, Center for Mental Health and Aging, The University of Alabama, 2003-present
Faculty Member, Center for Green Manufacturing, The University of Alabama, 2003-present
Adjunct Research Professor of Neurology, University of Alabama at Birmingham, 2004-present
Associate Professor, Dept. Biological Sciences, The University of Alabama, 2005-present
Scientist, Center for Experimental Therapeutics and Neurodegeneration,
University of Alabama at Birmingham, 2007-present
Honors:
Science Alliance Research Achievement Award Recipient, U. Tennessee, 1988, 1990-93
National Research Service Postdoctoral Fellowship Grant,
National Institute of Neurological Disease and Stroke, 1995-1998, 1st percentile rank
Howard Hughes Medical Institute Undergraduate Science Program Faculty Appointee
The University of Alabama, 1999-2003
Basil O'Connor Scholar of the March of Dimes Birth Defect Foundation, 2001
Blount Undergraduate Initiative Fellow, The University of Alabama, 2001
Honorary Member of the Golden Key International Honor Society, 2003
CAREER Award Recipient, National Science Foundation, 2003-2008
Honorary Member, The Anderson Society, The University of Alabama, 2005
Howard Hughes Medical Institute Investigator Nominee, 2004
Who's Who in America, 2005-present
Leadership Board Fellow, UA College of Arts & Sciences, 2005-2008
Carnegie Foundation and Council for the Advancement and Support of Education (CASE),
U.S. Professor of The Year, State of Alabama, 2005
Honorary Member, Omicron Delta Kappa (ODK), 2007
Professional Organizations:
American Epilepsy Society
American Society for Cell Biology
American Association for the Advancement of Science
Movement Disorders Society
Society for Neuroscience
International Brain Research Organization
Genetics Society of America
Teaching:
ALL of the following courses have been taught in their entirety by Dr. Caldwell:
• Integrated Genomics Laboratory (BSC 442)
Designed, equipped, and taught a new discovery-based undergraduate genomics and
bioinformatics laboratory course:
Taught every spring; 4 credit hours (with Writing component credit)
• http://www.bama.ua.edu/~gcaldwel/intgen.html
• A contract has been signed for a textbook based on this course with an
international publisher (Wiley) for release in 2006
• Signal Transduction in Neurobiology (BSC 494/BSC 594)
Designed and taught new literature-based undergraduate/graduate lecture course:
Taught every alternate fall semester; 3 credit hours
• Decoding Ourselves: The Impact of the Human Genome Project on Science and Society
(BUI 301-001) Designed and taught new undergraduate seminar course (for Blount Program)
Taught Fall 2001; 3 credit hours
• http://www.bama.ua.edu/~gcaldwel/blount.html
• Web-CT site developed for on-line student-monitored (instructor graded)
message board
• cover story of Howard Hughes Medical Institute website, April 2002
• currently taught annually by Dr. Kim Caldwell
• Honors General Biology I (BSC118)
Taught introductory biology course for University Honors Program students
Taught every alternate fall semester; 4 credit hours
• designed and used Web-CT module for instruction
• Common Book Experience (UHP 120-002)
Designed and taught new undergraduate seminar course for University Honors Program
Taught Fall 2003: 1 credit hour
• Current Topics in Nematode Neurobiology (BSC 695)
Designed and taught new graduate seminar course
Taught Spring 2005: 1 credit hour
• The Language of Research (BSC 497)
Taught undergraduate course on research culture and literature analysis for Howard
Hughes Research Interns; Lectures alternate between UA and Stillman College.
Taught Spring 2005; 2 credit hours
Independent Study (BSC 391) and Computer-Based Honors (CBH 202) Projects:
Designed and supervised four separate undergraduate projects for credit:
• Analysis of genetic database of several hundred Quicktime video images
of cell division in an attempt to identify novel gene targets related to a
human brain disease termed lissencephaly. Videos from our laboratory
have been requested for an upcoming textbook by Sinauer.
• Use of internet-based genetic databases in collaboration with researchers
at the National Cancer Institute for identification of novel genes termed
NORFs that were possibly missed by the Human Genome Project.
• Analysis of an internet database at Stanford University for profiling of
specific gene expression under different genetic and environmental
conditions using microarray ("gene chip") technology.
• Currently supervising an undergraduate Computer-Based Honors Program
student in the development of a novel bioinformatics database on the genetics of
epilepsy. This represents a unique research resource for the epilepsy
community: http://www.carpedb.ua.edu; published in
and highlighted in Science magazine and Biotechniques.
Grants and Contracts Funded
Dr. Guy Caldwell is the sole P.I. on all grants except where denoted by *
• Dystonia Medical Research Foundation
Title: "A Functional Genomic Analysis of Torsin Homologues in C. elegans"
1 yr., $35,000; March 2000-March 2001.
• University of Alabama Research Advisory Committee grant
Title: "Expression and Functional Analysis of C. elegans Nuclear Migration Genes"
2 years, $4,700; January 2000-January 2002.
• The March of Dimes Birth Defects Foundation: Basil O'Connor Scholar Award
Title: "Cytoskeletal Regulation of Nuclear Migration and Lissencephaly Proteins"
2 years, $150,000; February 2001-February 2003.
• Dystonia Medical Research Foundation
Title: "Analysis of Torsin Function in C. elegans"
1 yr., $20,000; Sept. 2001-Sept. 2003.
• University of Alabama Research Advisory Committee grant
Title: "Suppression of Parkinson's Disease Related Protein Aggregation by
C. elegans TOR-2" $4,998; Jan. 2002-Jan. 2004.
• American Parkinson's Disease Association
Title: ""C. elegans as an Animal Model to Discern the Functional Relationship
Between Torsin and Alpha-Synuclein Proteins in Parkinson's Disease"
$35,000; Sept. 2002-August 2003 (awarded but declined)
• Parkinson Disease Foundation and National Parkinson Foundation Joint
Research Grant Program
Title: "C. elegans as an Animal Model to Discern the Functional Relationship
Between Torsin and Alpha-Synuclein Proteins in Parkinson's Disease"
$35,000; June 2002-May 2003
• Invitrogen, Inc. Collaborative Research Contract;
$23,000, Sept. 2002-no end date.
• Michael J. Fox Foundation for Parkinson's Research
Title: "RNAi Screening and Analysis of Factors Influencing ER-Associated
Degradation and α-Synuclein Aggregation in C. elegans", $145,193; December
2002-2004.
• National Institutes of Health
Title: "Analysis of Torsin Protein in C. elegans", $141,000; February 2003-
January 2006.
• Center for Mental Health and Aging, The University of Alabama,
Title: "Molecular Analysis of Aging in an Animal Model for Parkinson's
Disease" $3500, 2003
• National Science Foundation CAREER Award
Title: "CAREER: An Integrated Discovery-Based Genomic Approach to
Discerning the Role of Nuclear Positioning Genes in Neurodevelopment"
$628,000, July 2003-2008
• Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award
Title: "Analysis of Torsin-mediated Protection from Cellular Stress in C. elegans"
Title: "Analysis of Torsin-mediated Protection from Cellular Stress in C. elegans"
$50,000, January 2003-2004 [Co-PI with Dr. Kim Caldwell]*
• Dystonia Medical Research Foundation
Title: "Chemical Screening for Torsin Effectors in C. elegans"
$39,000, Jan 2005-2006, [Co-PI with Dr. Kim Caldwell]*
• National Science Foundation
Title: "Confocal Microscopes for University of Alabama Optical Analysis
Facility", $298,570, August 1, 2004-2005 [Co-PI with Drs. Janis O'Donnell and
Edwin Stephenson]*
• Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award
Title: "Proteomic Analysis of Torsin Effectors & Functional Interactions
Pertaining to Dystonia"
$50,000, January 2005-2006 [Co-PI with Dr. Kim Caldwell]*
• National Science Foundation
Title: "Transmission Electron Microscopy for University of Alabama Optical
Analysis Facility", $399,000, funded, start date pending [Co-PI with Drs. Martha
Powell and Harriett Smith-Somerville]*
• National Institutes of Health
Title: "Use of C. elegans to Explore Bacterial Sources of Toxicity in Parkinson's
Disease", $294,900, funded, January 2005-December 2007
• Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award
Title: "Examining the Neuroprotective Capacity of Novel Gene Targets
Associated with Parkinson's Disease"
$50,000, January 2006-2007 [Co-PI with Dr. Kim Caldwell]*
• The Parkinson's Institute, contract award
Title: "STOP-PD Initiative: A Project to Identify a Compound that will Stop, and
Ideally Reverse Parkinson's Disease"
$100,000, March 2005-2006 [Co-PI with Dr. Kim Caldwell]*
• FoldRx Pharmaceuticals Inc., contract award
Title: "Compound Testing for Parkinson's Disease"
$8,190, July-September 2006 [Co-PI with Dr. Kim Caldwell]*
• Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award
Title: "Investigating Small Molecule Therapeutics for Torsion Dystonia"
$50,000, January 2007-2008 [Co-PI with Dr. Kim Caldwell]*
• FoldRx Pharmaceuticals Inc., contract award
Title: "Compound Testing for Parkinson's Disease "
$50,000, January 2007-August 2007 [Co-PI with Dr. Kim Caldwell]*
• Michael J. Fox Foundation for Parkinson's Research
Title: "Validation of VPS41, a protein involved in lysosomal trafficking,
as a target for Parkinson disease therapy" July 2007-June 2009 [Co-PI with Dr.
Kim Caldwell and Dr. David Standaert, UAB]*
• QRxPharma Ltd., sponsored research agreement
Title: "Drug Development for Neurological Diseases "
$2,000,000, June 2007-June 2012 [Co-PI with Dr. Kim Caldwell]*
Publications:
Textbooks Authored
Becker, J. M., Caldwell, G.A., and Zachgo, E. A. (1990) Biotechnology: A Laboratory
Course. Academic Press, Inc. (Harcourt Brace Jovanovich Publishers), San Diego
[Also published in Chinese]
Becker, J.M., Caldwell, G.A., and Zachgo, E.A. (1996) Biotechnology: A Laboratory
Course, 2nd Edition. Academic Press, Inc. (Harcourt Brace Publishers), San Diego.
[Also published in Spanish]
Caldwell, G.A., Williams, S.N., and Caldwell, K.A. (2006) Integrated Genomics: A
Discovery-based Laboratory Course. Wiley, Chichester, UK.
Book Chapters
Ewenson, A., Xue, C.-B., Marcus, S., Caldwell, G., Becker, J.M., and Naider, F. (1990)
"Synthesis of Biologically Active Analogs of a Lipopeptide Mating Pheromone from
Saccharomyces cerevisiae" In Peptides: Chemistry and Biology (Marshall, G.R., ed.)
Leiden Escom Science Publishers, p. 103-105.
Xue, C.-B., Marcus, S., Caldwell, G., Miller, D., Becker, J.M., and Naider, F. (1991)
"Structure-Activity Relationships of the Saccharomyces cerevisiae a-Mating factor", In
Peptides (Marshall, G.R., ed.) Leiden, The Netherlands: Escom Science Publishers, p.
899-901.
Caldwell, G.A., Cao, S., Gelwix, C.C., Sexton, E.G., and Caldwell, K.A. (2004) "An
Animal Model to Discern Torsin Function: Suppression of Protein Aggregation in C.
elegans" In Advances in Neurology: Dystonia 4 (Fahn, S., Marsden, D., and DeLong,
M., eds). Lippencott, Williams & Wilkens, New York, 94:79-85.
Caldwell, G.A., Cao, S., Izevbaye, I., and Caldwell, K.A. (2005) "Use of C. elegans to
Model Human Movement Disorders" In Animal Models of Movement Disorders
(LeDoux, M., ed.) Elsevier, New York, pp. 111-126.
Baumeister, R., Saman, J., Caldwell, K.A., and Caldwell, G.A. (2006) "Investigating
Alzheimer's and Parkinson's Disease using C. elegans", Wormbook (Chalfie, M., ed.)
in press
Journal Publications
Xue, C.-B., Caldwell, G.A., Becker, J.M., and Naider, F. (1989) "Total Synthesis of the
Lipopeptide a-Mating Factor of Saccharomyces cerevisiae" Biochem. Biophys.
Research Comm. 162:253-257.
Marcus, S., Caldwell, G.A., Xue, C.-B., Naider, F. and Becker, J.M. (1990)
"Total in vitro Maturation of the Saccharomyces cerevisiae a-factor Lipopeptide
Mating Pheromone". Biochem. Biophys. Res. Comm. 172:1310-1316.
Wielgus, J.J., Caldwell, G.A., Nichols, L. and White, C.F. (1990) "The Purification,
Characterization and Fate of a Haemolymph Trophic Factor from the Last Larval Instar
of Manduca sexta". Insect Biochem. 20:65-72.
Marcus, S., Caldwell, G.A., Miller, D., Xue, C.-B., Naider, F., and Becker, J.M. (1991)
"Significance of C-terminal Cysteine Modifications to the Biological Activity of
Saccharomyces cerevisiae a-factor Mating Pheromone". Mol. Cell. Biol. 11:3603-12.
Caldwell, G.A., Wang, S-H., Dawe, A.L., Becker, J.M., and Naider, F. (1993)
"Identification of a Hyperactive Mating Pheromone of Saccharomyces cerevisiae".
Biochem. Biophys. Res. Comm. 197:1173-1178.
Caldwell, G.A. and Becker, J.M. (1993) "Rapid PCR Sequencing of Plasmid DNA
Directly from Colonies of Saccharomyces cerevisiae." Promega Notes 44:6-9.
Ben-Yaacov, R., Knoller, S., Caldwell, G.A., Becker, J., and Koltin, Y. (1994)
"Candida albicans Gene Encoding Resistance to Benomyl and Methotrexate is a
Multidrug Resistance Gene". Antimicrob. Agents Chemother. 38:648-652.
Caldwell, G.A., Wang, S.-H., Naider, F., and Becker, J.M. (1994) "Consequences of
Altered Isoprenylation Targets on a-factor Export and Bioactivity". Proc. Natl. Acad.
Sci. USA. 91:1275-1279.
Caldwell, G.A., Wang, S.-H., Lu, H.-F., Naider, F., and Becker, J.M. (1994)
"Molecular Determinants of the Bioactivity of the Saccharomyces cerevisiae
Lipopeptide Mating Pheromone" J. Biol. Chem. 269:19817-19826.
Caldwell, G.A., Naider, F. and Becker, J.M. (1995) "Fungal Lipopeptide Mating
Pheromones: A Model System for the Study of Protein Prenylation"
Microbiological Reviews 59:406-422.
Gu, G., Caldwell, G.A., and Chalfie, M. (1996) "Genetic Interactions Affecting
Mechanosensation in C. elegans." Proc. Natl. Acad. Sci. USA. 13:6577-6582.
Dawe, A. L., Caldwell, K.A., Harris, P.M., Morris, N.R., and Caldwell, G.A. (2001)
"Evolutionarily conserved nuclear migration genes required for early embryonic
development in Caenorhabditis elegans." Dev. Genes Evol. 211:434-441.
Caldwell, G.A. (2003) "As the Worm Turns: Discovering a Life of Discovery" The
Washington & Lee Journal of Science 4:41-44 (invited review).
Caldwell G.A., Cao S., Sexton E.G., Gelwix C.C., Bevel J.P., and Caldwell K.A. (2003)
"Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans
by torsin proteins." Hum. Mol. Genet. 12(3):307-319. Cover story.
Caldwell, G.A. (2003) "New Insights and Strategies for Treating PolyQ Disorders"
Alzheimer Research Forum (on-line newsletter) http://www.alzforum.org; Feb. 15, 2003
Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A.,
Lin, S-H., Yu-Lee, L. (2003) "A Role for NudC, a Dynein-Associated Nuclear
Movement Protein, in Mitosis and Cytokinesis" J. Cell Sci. 116:1991-2003.
Swatloski, R.P. Rogers, R.D., Holbrey, J.D., Turner, M.B., Memon, S.B. Caldwell, G.A.
and Caldwell, K.A., (2004) "Using Caenorhabditis elegans to Probe Toxicity of 1-
alkyl-3-methylimidazolium Chloride Based Ionic Liquids" Chem. Comm. 6:689-90.
Williams, S.N., Locke, C.J., Braden, A.L., Caldwell, K.A., and Caldwell, G.A. (2004)
"Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of
neurotransmitter signaling in C. elegans" Hum. Mol. Genet., 13:2043-2059.
Zhang, S., Keller, C. A., Yao, C. A., Caldwell, G.A., and Chalfie, M. (2004) "MEC-2 is
recruited to the putative mechanosensory complex in C. elegans touch receptor neurons
through its stomatin-like domain," Curr. Biol. 14:1888-1896.
Cao, S., Gelwix, C.C., Caldwell, K.A., and Caldwell, G.A. (2005) "Torsin-mediated
protection from cellular stress in the dopaminergic neurons of Caenorhabditis
elegans." J. Neurosci. , 25:3801-3812.
Locke, C.J., Caldwell, K.A., and Caldwell, G.A. (2005) "CarpeDB: A comprehensive
database on the genetics of epilepsy" Nucleic Acids Res. 33:D5-24.
Dickey, C.A., Dickson, D., Yue, M., Lin, W-L., Dunmore, J., West, G., Patterson, C.,
Cao, S., Clark, A.K., Caldwell, G.A., Caldwell, K.A., Eckman, C., Hutton, M., and
Petrucelli, L. (2006) "Deletion of CHIP leads to caspase-3 activation and neuronal
apoptosis associated with increases in non-ubiquitinated, soluble phospho-tau species
without neurofibrilary tangles. J. Neurosci. 26:6985-6996.
Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K.,
Xu, K., Strathearn, K.E., Liu, F., Cao, S., Caldwell, K.A., Caldwell, G.A.,
Marsischky, G., Kolodner, R.D., , LaBaer, J., Rochet, J-C., Bonini, N.M., and
Lindquist, S. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 Rescues
Neuron Loss in Parkinson's Models. Science, 313:324-328.
Locke, C.J., Williams, S.N., Schwarz, E.M., Caldwell, G.A., and Caldwell, K.A. (2006)
"Genetic Interactions Among Cortical Malformation Genes that Influence
Susceptibility to Convulsions" Brain Research 1120:23-34.
Suessmann, R., Sharma, P., Hajjar, C., Caldwell, K.A., Caldwell, G.A., Du Brueil, R.,
Moore, R., and Boyd, L. "Ubiquitin Conjugating Enzymes Participate in
Polyglutamine Protein Aggregation" submitted to BCM Molecular and Cell Biol.
Patents
Caldwell, G.A. and Caldwell, K.A. "Nucleotide Sequences that Code for Torsin Genes,
Torsin Proteins, and Methods of Using the Same to Treat Protein-Aggregation"
Patent Pending, 16 foreign filings also in review.
Caldwell, G.A. and Caldwell, K.A. "Regulators of Protein Misfolding and Aggregation
and Methods of Using the Same" Patent Pending.
Caldwell, G.A, Caldwell, K.A., Cao, S. "Methods of Using Small Molecule Compounds
for Neuroprotection" Patent Pending.
Consulting:
The Council of Healthcare Advisors, Gerson Lehrman Group (New York, NY), 2001-present
The Science Advisory Board, 2002-present
Scientific Advisory Board, QRxPharma, 2007-present
Grant Reviewer:
Ad-hoc, National Science Foundation, CAREER Award Program, 2003-present
Ad-hoc, National Science Foundation, 2005-2007
Ad-hoc, The Wellcome Trust
Editorial Boards
American Journal of Alzheimer's Disease and Other Dementias, 2004-present
Journal of Opioid Management, 2005-present
Editorial Reviewer/Contributor:
McGraw-Hill Publishers
Harcourt/Elsevier Publishing
John Wiley & Sons Publishers
Ergito Genetics (Benjamin Lewin, on-line publisher)
Benjamin Cummings/Addison Wesley Publishers
The Scientist
Alzheimer's Research Forum
JOSHUA (Journal of Science and Health at the University of Alabama), Faculty Advisor
Journal Reviewer:
Brain Research
Biochemistry
Developmental Brain Research
Genesis, The Journal of Genetics and Development
Genome Research
Human Molecular Genetics
Proceedings of the National Academy of Sciences (PNAS)
Neurobiology of Disease
Neurogenetics
Trends in Parasitology
Neurobiology of Aging
Committees and Miscellaneous Service:
Premier Awards Committee, Member, The University of Alabama, member 2002-2005
Premier Awards Committee, Co-Chair, The University of Alabama, 2006-present
Institutional Biosafety Committee, The University of Alabama, 2000-present
Graduate Committee, Dept. Biological Sciences, The University of Alabama, 2000-2004
Search Committee, Evolutionary-Developmental Biologist, Dept. Biological Sciences,
The University of Alabama, 2003
Search Committee, Associate V.P. for Research, The University of Alabama, 2004
Student Recruitment Advisory Board, The University of Alabama, 2004-present
Graduate Recruitment Committee, UA Dept. Biological Sciences, 2004-present
Workshop & Activities Coordinator, Howard Hughes Medical Institute Undergraduate
Research Intern Program, University of Alabama-Stillman College, 2000-present
Organizer and Lecturer, Human Genome Workshop, co-sponsored with Zeta Phi Beta,
for Tuscaloosa minority community, 2002-2004
Faculty Advisor, UA Chapter of Beta Beta Beta, National Biology Honor Society, 2001-2005
Faculty Advisor, JOSHUA: The Journal of Science and Health at the University of Alabama
Faculty Advisor to 26 undergraduates each semester (for registration, career advice, etc.)
Originator and Lecturer, Touch of Class Pregame Seminar Series, UA College of Arts &
Sciences, Fall 2004-present
Organizer and Lecturer, Scientist-for-a-Day Competition, Paul W. Bryant High School,
Tuscaloosa, 2004-2007
Search Committee Chair, Cellular Signaling position, Dept. Biological Sciences, The
University of Alabama, 2005-06
Graduate Students Trained:
Completed Degrees and Honors:
Michael A. Shiffler, M.S., 2002
2000-01 University-wide recipient of Excellence in Teaching for a Masters Student
2001 Hill Fellowship, Department of Biological Sciences
currently a M.B.A./Ph.D. student at UA (with Dr. Ed Stephenson)
Elaina Sexton, M.S., 2002
currently a medical student, University of South Alabama
Christopher C. Gelwix, M.S., 2003
Graduate Council Fellowship Recipient 2002-03
currently a medical resident, Medical College of Virginia
Summer Slater, M.S. , 2005
currently a biology/chemistry teacher at a private academy in Lafayette, LA
Shelli N. Williams, M.S. 2004, Ph.D., 2006
2001 Isabella Hummel Graham Scholarship Recipient, University Women's Club
Graduate Council Research Fellowship Recipient, Summer 2000
Graduate Council Thesis Fellowship Recipient, Fall 2001-Summer 2001
Graduate Student Registration Award, American Society for Cell Biology, 2001
13th International C. elegans Meeting, Student Travel Award, 2001
Research and Travel Award, UA Graduate School, 2001
Research and Travel Award, UA Graduate School, 2002
Worthington Award Recipient, American Society for Cell Biology, 2002
14th International C. elegans Meeting, Top Poster Award Recipient, 2003
The Joab Langston Thomas Award, UA Biological Sciences, 2005
currently employed by Central Intelligence Agency, Washington, D.C.
Songsong Cao, M.S., 2005, Ph.D., 2006
Graduate Council Fellowship Recipient, 2000-01 and 2003-04
Competitive Graduate Student Travel Award, American Society for Cell Biology, 2001
Research and Travel Award, UA Graduate School, 2001
Research and Travel Award, UA Graduate School, 2002
The Joab Langston Thomas Award, UA Biological Sciences, 2004
The University of Alabama Excellence in Research by a Doctoral Student Award, 2005
Currently a postdoctoral fellow, Duke University
Current Graduate Students:
Shusei Hamamichi, Ph.D. Student, 2003-present
Jafa Armagost, Ph.D Student, 2005-present
Pan Chen, Ph.D. Student, 2006-present
Adam Harrington, Ph.D. Student, 2006-present
Michelle Tucci, M.S. student, 2006-present
Bwarenaba Kautu, M.S. student, 2006-present
Alexander Burdette, Ph.D. student, 2007-present
Undergraduates Supervised in Research and Notable Honors:
John Paul Bevel, 2000-2001
Author on manuscript in peer-reviewed journal
currently a research technician
Clay Blanton, 2000
currently in information technology
Shelli Williams, 2000
Author on 3 manuscripts in peer reviewed journals and textbook author
Jenny Whitworth, 2000-2002
Howard Hughes Medical Institute Research Intern, 2000-2002
currently a medical doctor
Sarah Howard, 2001
currently in information technology
Daniel Wyatt, 2001-2002
currently in pharmacy school
Meiklejohn McKenzie, 2001
currently a medical doctor
Sarah B. Adair, 2001-2003
USA Today All-USA Academic Team, 1st Team 2003 (top 20 nationally)
USA Today All-USA Academic Team, 3rd Team 2003 (top 60 nationally)
Goldwater Scholar, 2002
Pi Kappa Phi, Undergraduate Research Award, 2002
Howard Hughes Medical Institute Research Intern, 2001-03
McWane Undergraduate Research Award, 2002
Randall Outstanding Undergraduate Research Award, 2003
Outstanding Senior Award, 2003
currently a medical student at UAB
Andrea Braden, 2002-2003
Randall Outstanding Undergraduate Research Award, 2003
Pi Kappa Phi, Undergraduate Research Award, 2003
Howard Hughes Medical Institute Research Intern, 2002-03
currently a medical resident, University of Connecticut
Author on manuscript in peer reviewed journal
Cody Locke, 2002-2006
USA Today All-USA Academic Team, 1st Team 2006 (top 20 nationally)
USA Today All-USA Academic Team, 2nd Team 2004 and 2005 (top 40 nationally)
Benjamin-Cummings Biology Award Recipient, 2003 (1 of only 4 nationally)
Randall Outstanding Undergraduate Research Award, 2004 and 2005
Merit Award Recipient, National Society for Collegiate Scholars, 2004 (1 of 50 nationally)
Outstanding Sophomore, UA College of Arts & Sciences, 2003-2004
Howard Hughes Medical Institute Research Intern, 2004-present
Goldwater Scholarship Recipient, 2005
UA Alumni Association Outstanding Senior, male, 2006
1st Place, University of Alabama System-Wide Honors Research Competition, 2006
Author on 3 manuscripts in peer reviewed journals
Currently research technician, Caldwell lab
Matthew Cybulsky, 2003
Howard Hughes Medical Institute Research Intern, 2001-2003
currently pursuing a M.S. in Hospital Administration (following receipt of an M.S.
in Bioethics at Case Western Reserve University)
Amy Shirley, 2003-2004
Randall Outstanding Undergraduate Research Award, 2004
Howard Hughes Medical Institute Research Intern, 2003-2004
currently a Ph.D. student at UA (Sloan lab)
Kimberly Peters, 2003-2005
Outstanding Sophomore of the College of Arts & Sciences, 2002-03
Howard Hughes Medical Institute Research Intern, 2003-2005
McWane Undergraduate Research and Travel Award. 2004
1st Prize, University of Alabama Undergraduate Research Competition, 2004
currently Ph.D. student at UNC Chapel Hill
Shermeen Memon, 2004-2006
Outstanding Sophomore, The University of Alabama, 2003-04
1st Prize, Univ. of Alabama Undergraduate Research Competition, 2004 and 2006
Randall Outstanding Undergraduate Research Award, 2005 and 2006
Howard Hughes Medical Institute Research Intern, 2005-present
UA Alumni Association Outstanding Senior, female, 2006
1st Place, University of Alabama System-Wide Honors Research Competition, 2006
Author on manuscript in peer-reviewed journal
currently medical student at UAB
Amber Clark, 2004-2006
Howard Hughes Medical Institute Research Intern, 2004-present
3rd Prize, University of Alabama Undergraduate Research Competition, 2005
Randall Outstanding Undergraduate Research Award, 2006
Author on manuscript in peer-reviewed journal
Currently research technician, Caldwell lab
Perry Guevara, 2004
Stephanie Brennan, 2004
John Philips, 2004-2006
Truman Scholarship Recipient, 2005
Howard Hughes Medical Institute Research Intern, 2005-present
currently medical student at Vanderbilt
Renee Rivas, 2004-present
NSF REU grant recipient
Howard Hughes Medical Institute Research Intern, 2006-present
3rd Place, University of Alabama System-Wide Honors Research Competition, 2006
Goldwater Scholarship Recipient, 2006
McWane Undergraduate Research Award, 2006
Benjamin-Cummings Biology Award Recipient, 2006 (1 of only 4 nationally)
Meaghan Till, 2005-2006
2006 Isabella Hummel Graham Scholarship Recipient, University Women's Club
Howard Hughes Medical Institute Research Intern, 2006
Robyn Thomas, 2005-2007
Howard Hughes Medical Institute Research Intern, 2005-present
2nd Place, University of Alabama System-Wide Honors Research Competition, 2006
Amgen Fellow, Teach for America (1 of 50 from 20,000 applicants nationwide)
Ashley Phares, 2005-present
Stacey Fox, 2005-present
Jeana Blalock, 2005-2007
Howard Hughes Medical Institute Research Intern, 2006-present
Adam Knight, 2005-present
David Agee, 2006
Howard Hughes Medical Institute Research Intern, 2006
Kyle Lee, 2006-present
Susan DeLeon, 2006-present
John Ricketts, 2006-present
Max Thompson, 2006-present
Lauren Bryant, 2006-present
Alicia Wright, 2006-2007
Kalen Berry, 2006-present
Presentations:
Meetings
• American Society for Cell Biology, International Meeting, San Francisco, December
8-14, 2000. 1 presentation
• 13th International C. elegans Meeting, Los Angeles, June 22-26, 2001
4 separate presentations given
• American Society for Cell Biology, International Meeting, Washington, D.C.
December 8-14, 2001. 2 presentations given
• 4th Annual Conference of the Southern Association for the History of Medicine and
Science, The Ochsner Clinic Foundation, New Orleans, LA Feb. 22-23, 2002
invited keynote speaker
• 5th Annual Graduate Student Research Conference, The University of Alabama,
March 13-14, 2002 2 presentations given
• 4th International Dystonia Symposium, Emory University, Atlanta, June 13-15, 2002
invited platform speaker
• Midwest C. elegans Meeting, St. Louis, June 28-30, 2002. 2 presentations
• American Society for Cell Biology 42nd Annual Meeting, San Francisco, Dec. 14-18,
2002, 4 presentations given
• 17th National Conference on Undergraduate Research, March 13-15, 2003, Salt Lake
City, UT. 1 presentation
• Ubiquitin & Ubiquitin-like Modifications in Health & Disease Meeting, NIH,
Bethesda, MD, March 23-24, 2003, 1 presentation
• Alabama Dieticians Association Annual Meeting, Montgomery, AL, March 20, 2003,
invited lecturer
• 14th International C. elegans Meeting, Los Angeles, CA, June 8-July 3, 2003,
4 presentations
• Northwest Regional Dystonia Symposium, Tacoma, WA, July 27-28, 2003,
invited lecturer
• Cell Biology of the Neuron, 2003 Society for Neuroscience Meeting, New Orleans, LA,
Nov. 7, 2003, 2 presentations
• Bachmann-Strauss Dystonia & Parkinson Foundation 2003 Think Tank,
New York, NY, Nov. 13-15, 2003, invited lecturer
• Dystonia Medical Research Foundation 2004 Grantholders Workshop,
Atlanta, GA, Feb. 19-20, 2004, invited platform lecturer
• 6th Annual Graduate Student Research Conference, The University of Alabama
March 11, 2004, keynote speaker
• 2nd Canadian Developmental Biology Symposium, Banff, Canada, Apr. 4, 2004
1 presentation
• 8th International Congress of Parkinson's Disease & Movement Disorders,
Rome, Italy, June 13-17, 2004, 2 presentations
• 10th Annual Spasmodic Torticollis Dystonia International Patients Meeting
Orlando, FL Oct. 1-2, 2004, invited platform lecturer
• Society for Neuroscience Annual Meeting, San Diego, CA,
2 presentations
• 28th Annual Meeting of The American Epilepsy Society, New Orleans, LA, Dec. 3-8,
2004, invited presentation
• American Society for Cell Biology, 44th International Meeting, Washington, D.C.
December 4-9, 2004. 2 presentations
• 15th International C. elegans Meeting, Los Angeles, CA, June 25-29, 2005
7 presentations
• 29th Annual Meeting of The American Epilepsy Society, Dec. 4-8, 2004, invited
invited platform lecturer
• American Society for Cell Biology, 45th International Meeting, San Francisco, CA
December 10-14, 2005. 3 presentations
• Genetics Society of America, Model Organisms to Human Biology, San Diego, CA
January 5-7, 2006
• 2006 Biotechnology Association of Alabama Annual Meeting, Birmingham, AL
February 3, 2006, invited lecturer
• Cambridge Healthscience Institute, Protein Folding Disorders Meeting,
Baltimore, MD, March 9-10, 2006, invited platform lecturer
• Bachmann-Strauss Dystonia and Parkinson Foundation Think Tank,
United Nations Plaza, November 15-16, New York, NY, invited lecturer
• American Society for Cell Biology, 45th International Meeting, San Diego, CA
December 9-13, 2006. 5 presentations
• NIH/Dystonia Medical Research Foundation Workshop, Animal Models of
Dystonia, January 11-12, Washington, D.C., invited lecturer/session leader
Invited Seminars (in addition to those at meetings):
Pasteur Society, The University of Alabama, Oct. 19, 1999
• Washington & Lee University, Lexington, VA, Biology Department, Dec. 4, 1999
• The University of Alabama at Huntsville, Biology Department, Dec. 8, 1999
• Mississippi State University, Starkville, MS. Department of Biochemistry and
Molecular Biology, Dec. 6, 2000
• Alabama Science-In-Motion, high schoolteacher enhancement program, Feb. 20, 2001.
• WalkAmerica Walk-a-thon fundraiser, Birmingham, AL
The March of Dimes Birth Defects Foundation, Feb. 27, 2001, keynote speaker
• WalkAmerica Walk-a-thon Kickoff Fundraiser, Tuscaloosa, The March of Dimes
Birth Defects Foundation, Mar. 13, 2001, keynote speaker
• Tri-Beta, National Biological Honor Society, UA chapter, Apr. 12, 2001
• Alpha Epsilon Delta, Premedical Honorary, UA chapter, Oct. 30, 2001
• University of Maryland Biotechnology Institute, Dec. 6, 2001
• Weis Center for Research, The Geisinger Clinic, Danville, PA, Mar. 22, 2002
• Rhodes College, Memphis, Department of Biology, Apr. 12, 2002
• Tuscaloosa Dietetic Association, Apr. 23, 2002
• University of Alabama at Birmingham Medical School, Department of Cell Biology,
Apr. 24, 2002
• UA School of Library and Information Studies, Medical Informatics Program,
Apr. 30, 2002
• Blount Program Convocation, The University of Alabama, February 2003
• Parker-Adams Seminar Series, The University of Alabama, March 2003
• UA Leadership Board, Spring Meeting 2003
• Southern Research Institute, Birmingham, AL April 25, 2003
• Alabama Parkinson's Disease Association, Birmingham, AL, Aug. 17, 2003
• University of Alabama Huntsville, Hudson Biotechnology Lecture Series, Oct. 19, 2003
• Shelton State Community College, Tuscaloosa Phi Theta Kappa Leadership Series,
Oct. 29, 2003
• Tulane University, Dept. Cell & Molecular Biology, New Orleans, LA, Oct. 31, 2003
• Stanford University, Department of Genetics Palo Alto, CA, Dec. 15, 2003
• The Parkinson's Institute, Sunnyvale, CA, Dec. 15, 2003
• University of Idaho, Moscow, ID, Dept. Biological Sciences, Apr. 9, 2004
• University of Alabama at Birmingham Medical School, Grand Rounds in Neurology,
May 25, 2004
• Mississippi State University, Starkville, MS, Dept. Biological Sciences, Aug. 20, 2004
• The University of Alabama, Tuscaloosa, Dept. Biological Sciences, Sept. 2, 2004
• Parkinson's Association of Alabama, Birmingham, AL, Oct. 17, 2004
• The Michael J. Fox Foundation, Las Vegas, NV, Jan. 19, 2005
• Gene Therapy Center at UAB, Feb. 1, 2005
• Rogers Science & Engineering, Library, seminar for UA community, Feb. 9, 2005
• Washington & Lee University, Lexington, VA, University Lecturer, Feb. 28, 2005
• Washington & Lee University, Lexington, VA, Biology Dept. seminar, March 1, 2005
• New Mexico State University, Las Cruces, NM, Dept. Biological Sciences,
April 21, 2005
• Dystonia Medical Research Foundation Patient Symposium, Los Angeles, CA,
May 18, 2005
• South Alabama Dystonia Support Group, Mobile, AL, June 5, 2005
• The Mayo Clinic, Jacksonville, FL, Alzheimer's and Parkinson's Lecture Series,
August 12, 2005
• Seton Hall University, West Orange, NJ, Sept. 21, 2005
• Reynolds Lecture, University of Alabama at Birmingham, Reynolds Historical
Library, Oct. 19, 2005
• University of Alabama System-Wide Honors Research Day, keynote lecturer,
April 14, 2006
• Dystonia Medical Research Foundation Patient Symposium, Chicago, May 17, 2006
• University of Tennessee, Knoxville, TN, Biochemistry, Cell & Molecular Biology
Departmental Retreat, keynote lecturer, August 21, 2006
• Parkinson's Association of Alabama, 2006 Annual Meeting, Birmingham, AL,
Sept. 13, 2006
• Paul W. Bryant High School, Tuscaloosa, AL, Oct. 5, 2006
• University of Alabama at Birmingham, Dept. Biochemistry & Molecular Biology
and Dept. of Neurobiology Joint Seminar, Nov. 20, 2006
• University of West Alabama, Biology Department Seminar, Dec. 1, 2006
• University of Alabama, Gorgas Library Public Lecture Series, Feb. 22, 2007
• University of Tennessee-Oak Ridge National Laboratory Genome Science and
Technology Program, March 9, 2007
• Pennington Biomedical Research Center, Baton Rouge, LA, March 16, 2007
• City University of New York (CUNY), College of Staten Island,
Center for Developmental Neuroscience and Developmental Disabilities,
New York, NY, May 21, 2007
Media Relations:
Newspaper and Magazine Articles
• Dialog, cover story on my teaching, February 7, 2000
• UA Press Release on my teaching, February 23, 2000
• The Birmingham News, story on my teaching, February 28, 2000
• The Crimson White, story on my teaching, April 6, 2000
• The Tallassee Tribune, story on my research, June 8, 2000
• The Tuscaloosa News, full-page feature story on my research, June 16, 2000
• The Crimson White, story on my research, June 28, 2000
• The Progress (a New Jersey paper), story on my research, July 2000
• The Birmingham News, story on my research, August 21, 2000
• Library Horizons: A Newsletter of UA Libraries, story on electronic databases, Fall 2000
• UA Press Release on grant award from March of Dimes, Feb. 23, 2001
• Dateline Alabama, feature story on my research, March 6, 2001
• The Crimson White, story on my research, March 8, 2001
• The Anniston Star, feature story on my research. March 18, 2001
• The Tuscaloosa News, cover story on my research and a profile of my graduate student,
Mike Shiffler, March 29, 2001
The Huntsville Times, Health Notes, story on my research, March 30, 2001
• The Birmingham Post-Herald, feature profile on my career, April 2, 2001
• Alabama Alumni magazine, story on my research, April/May 2001
• The Decatur Daily, story on my research and student, Sarah Adair, July 11, 2001
• The Tuscaloosa News, consulted for front-page story on, stem cells, Aug. 10, 2001
• UA Press Release on my teaching, Nov. 14, 2001
• The University of Alabama Research Magazine, feature story on my research, 2002
• The Tuscaloosa News, story on my research and career profile of my wife and myself
February 10, 2002
• UA Press Release on my research with undergraduate Sarah Adair, Feb. 27, 2002
• USA Today, story on my student Sarah Adair, a 3rd Team selection to the USA Today
All-USA College Academic Team, for her research in my lab, February 27, 2002
• The Progress (a New Jersey paper), career profile and story on my research, April 11, 2002
• Howard Hughes Medical Institute Website, cover story on my teaching, April 2002
• Collegian, UA Arts & Sciences, story on my research student Sar, ah Adair, September 2002
• Dystonia Dialogue (Chicago),, , , newsletter for dystonia medical research and patient
community, biography, career profile, and feature story on my research, Oct. 2002
• Michael J. Fox Foundation for Parkinson's Research, international press release on my
receipt of one of only 11 grants awarded internationally for Parkinson's Research,
Jan. 13, 2003
• UA Press Release, story on my receipt of one of only 11 grants awarded internationally
from the Michael J. Fox Foundation for Parkinson's Research, Jan. 17, 2003 (see
listing of many resulting news stories nationally)
• The Tuscaloosa News, story on Michael J. Fox grant, Jan. 20, 2003
• UA Press Release, story on our publication of the cellular function of a gene related to a
human movement disorder termed dystonia, Jan. 29, 2003
• Howard Hughes Medical Institute, international press release, on our discovery
pertaining to the cellular cause of dystonia, February 1, 2003
• Dystonia Medical Research Foundation, cover story of their webpage: www.dystoniafoundation.
org, on our discovery pertaining to the cellular cause of dystonia,
February 1, 2003
• Dialog, story on Michael J. Fox grant, Feb. 3, 2003
• UA Press Release, story on my Ph.D. student Shelli Williams for receipt of the
prestigious Worthington Award for her research, Feb. 5, 2003
• Dateline Alabama, story on Michael J. Fox grant, Feb. 9, 2003
• USA Today, cover story on my student Sarah Adair, a 1st Team selection to the USA Today
All-USA College Academic Team, for her research in my lab, Feb. 13, 2003
• Dateline Alabama, story on my Ph.D. student Shelli Williams, February 20, 2003
• Baldwin Register, story on my Ph.D. student Shelli Williams for Worthington Award,
Feb. 19, 2003
• The Tuscaloosa News, story about a workshop on the Human Genome Project that my
I organized for the local minority community, Feb. 23, 2003.
• Alabama Alumni Magazine, story on Michael J. Fox grant, March 2003
• DatelineAlabama, story on undergraduate science journal, JOSHUA, that I initiated as
faculty advisor of Tri-Beta, March 14, 2003
• National Institutes of Neurological Disease and Stroke, cover story:
www.ninds.nih.gov, on our discovery pertaining to the cellular cause of dystonia,
March 28, 2003
The Crimson White, story on undergraduate science journal, JOSHUA, March 31, 2003
• Alabama Alumni Magazine, story on undergraduate science journal, JOSHUA, March 2003
• The following websites also posted feature stories on our discovery pertaining to the
cellular cause of dystonia in between February-March 2003:
o www.wiat.com, WIAT TV-42, Medical Minute
o www.eurekalert.org, EurekAlert biomedical news site
o www.ParkinsonsChat.com. Parkinson's Disease Treatment & Information site
o www.al.com, Alabama news site
o www.northernlight.com, medical news site
o www.sciencedaily.com, science news site
o www.scienceblog.com, science news site
o www.cnsfoundation.org, children's neurobiological solutions foundation site
o www.ms-network.org, multiple sclerosis site, Global Medical News story section
o www.hdlighthouse.org, Huntington's disease research and patient site
o www.wpda.org, World Parkinson Disease Association site
o www.aidschat.com, AIDS and biomedical research site
o www.wemove.org, movement disorders newsletter
• Dialog, cover story featuring my wife and myself on our discovery pertaining to the
cellular cause of dystonia, March 31, 2003
• Biophotonics International, "Prospects in Medicine: GFP sheds light on protein
folding", feature story on our discovery pertaining to the cellular cause of
dystonia, April 2003 issue
• The Scientist, international science news magazine, "Researchers Reveal a New Twist in
Torsion Dystonia", feature story on our discovery pertaining to the cellular cause
of dystonia, April 21, 2003 issue and www.the-scientist.com
• Howard Hughes Medical Institute Bulletin, "Brain Drain", feature story on our
discovery pertaining to the cellular cause of dystonia, June 2003 issue.
• The Parkinson's Institute, press release on Michael J. Fox grant, June 2, 2003
• Alabama Alumni Magazine, cover story on my student Sarah Adair, "The Best and The
Brightest Times 5", on her selection to the USA Today All-USA College
Academic 1st Team, for her research in my lab, June 2003
• UA Press Release, story related to my receipt of a National Science Foundation
CAREER Award, July 11, 2003
• The Tuscaloosa News, cover story, West Alabama section, related to NSF CAREER
Award and research into human epilepsy, July 24, 2003
• The Times Daily, story related to NSF CAREER Award/epilepsy, July 24, 2003
• Sarasota Herald-Tribune (FL), story related to NSF CAREER Award/epilepsy, July 24, 2003
• The Birmingham News, story related to NSF CAREER Award/epilepsy, July 24, 2003
• Gadsden Times, story related to NSF CAREER Award/epilepsy, July 25, 2003
• NBC13.com, Healthbeat13, story related to NSF CAREER Award/epilepsy, July 25, 2003
• Washington & Lee Alumni Magazine, feature story about our research, Summer 2003
• UA Press Release, story on my freshman research student Cody Locke, who was selected as
the recipient of the 2003 Benjamin-Cummings Biology Prize (1 of 4 nationally) for his
work in my laboratory into epilepsy genetics, Aug. 6, 2003
• Dystonia Medical Research Foundation 2002 Annual Report, "Foundation-Funded
Investigator Discovers Function of TorsinA", featured story on our research, Aug. 2003
• Crimson Tide Kickoff Football Game Program, feature story on Cody Locke Sept. 20, 2003
• Strategies: Benjamin Cummings Newsletter, feature story on Cody Locke Sept. 20, 2003
• American Society for Cell Biology 2003 Press Book, international press release and media
guide (1 of 13 abstracts selected from meeting of ~10,000 attendees)
• Science magazine, feature online research news article, on a separate Caldwell Lab
report at the 2003 American Society for Cell Biology international meeting.
• Biophotonics International, "Fluorescence Provides Insight into Seizure Mechanisms",
news story on our discovery pertaining to the cellular cause of epilepsy, Jan. 2004
• USA Today, cover story on my student Cody Locke, a 2nd Team selection to the USA
Today All-USA College Academic Team, for his research in my lab, Feb. 11, 2004
• UA Press Release, story on my undergraduate research student Cody Locke and USA
Today selection, Feb. 12, 2004
The Crimson White, story on my graduate students receiving the prestigious Worthington
Award from the American Society for Cell Biology 2 years in a row, Feb. 20, 2004.
• Dialog, story on my undergraduate research student Cody Locke and his USA
Today selection for his research into epilepsy, Feb. 23, 2004
• E-MOVE Movement Disorders Newsletter, international press release announcing our work
as one of 2 selected highlights from the 3000 person 8th International Movement
Disorders Congress (Rome, Italy); July 9, 2004.
• US News & World Report, full-page advertisement citing my student Cody Locke as 1 of 4
USA Today All-USA Academic Team selections. August 30, 2004
• Howard Hughes Medical Institute, international press release announcing our development
of a C. elegans model for human epilepsy; Sept. 1, 2004
• The Scientist, research story on our development of a model for human epilepsy Sept. 2004
• A Touch of Class, UA College of Arts & Sciences, Pre-football game lecturer, Sept. 2, 2004
• The Tuscaloosa News, feature story on our research into epilepsy, Oct. 4, 2004
• UAB Reporter, story on our research into epilepsy, Oct. 4, 2004
• DystoniaST, news magazine, feature story on our research, cover photo, Jan. 2005
• Dialog, photo and story about high-school outreach program I founded, Scientist-for-a-Day
• USA Today, 2005 All-USA Academic Team, story on my student Cody Locke and his
research in our lab, Cody was named to this team for the 2nd year in a row, Feb. 17. 2005
• Science magazine, NetWatch, feature story on epilepsy database generated in our lab,
Feb. 7, 2005 issue
• Dialog, story on Cody Locke being named to USA Today All-Academic Team, Feb. 7. 2005
• The Bulletin of the Howard Hughes Medical Institute, Winter 2005 issue, feature story on my
research and mentorship with undergraduates
• Inside Higher Ed, newsletter with feature story "Young Biologist Seizes the Moment" on my
research with Cody Locke, March 3, 2005
• UA Press Release, "UA Scientists Demonstrate Protein's Therapeutic Potential for
Parkinson's" April 12, 2005
• The Tuscaloosa News, cover story, "UA Team Takes Step in Finding Treatment", on my
research into Parkinson's disease, April 14, 2005
• The Associated Press, national press release "UA Team Advances Parkinson's Treatment",
on my research into Parkinson's disease, April 14, 2005
• Atlanta Journal Constitution, story on my research into Parkinson's disease, April 14, 2005
• Columbus Ledger-Inquirer, story on my research into Parkinson's disease, April 14, 2005
• AL.com, story on my research into Parkinson's disease, April 14, 2005
• Dateline Alabama, story on my research into Parkinson's disease, April 14, 2005
• Gadsen Times, story on my research into Parkinson's disease, April 14, 2005
• Times Daily, story on my research into Parkinson's disease, April 14, 2005
• Anniston Star, story on my research into Parkinson's disease, April 15, 2005
• Biloxi Sun Herald, story on my research into Parkinson's disease, April 16, 2005
• National Institute of Neurological Disorders and Stroke, national press release on my
research into Parkinson's Disease, cover of NINDS webpage, June 3, 2005
• News-Medical.Net, story on my research into Parkinson's disease, June 4, 2005
• Collegian, UA Arts & Sciences, story on my receipt of Leadership Board Fellowship,
October 2005
• The Bachmann-Strauss Dystonia and Parkinson Foundation Outlook Newsletter, cover story
on our dystonia and Parkinson's research, Fall 2005
• CASE Press Release on U.S. Professors of the Year, www.case.org, November 17, 2005
• The Birmingham News, feature article on my being named Professor of the Year for the State
of Alabama from the Carnegie Foundation and CASE, Nov. 17, 2005
• UA Media Relations Web Site Package about my being named Professor of the Year,
www.ua.edu/academic/professorofyear
• Crimson White, feature story on my wife and myself, as a research team, January 2006
• USA Today, feature story on Cody Locke, Caldwell Lab undergraduate researcher, named to
USA Today All-USA Academic 1st Team, February 2006
• Howard Hughes Medical Institute Bulletin, Winter 2006 Bulletin, brief story about being
named Professor of the Year
• eTORCH, Univ. of Tennessee Alumni Newsletter, feature story about being named
Professor of the Year, March 2006
• Alabama Alumni Magazine, feature story on being an inventor on several patents,
Spring 2006
• Dialog, UA Faculty/Staff newsletter, feature story on my student, Renee Rivas, 2006
Goldwater Scholarship recipient
• BAMA BOUND, featured participant on recruiting DVD, May 2006
• The Tuscaloosa News, feature story on new Parkinson's drug screening pipeline with our lab
and The Parkinson's Institute, May 6, 2006
• The PI Newsletter, The Parkinson's Institute, Sunnyvale, CA, Spring 2006
• Dialog, UA Faculty/Staff newsletter, story on new Parkinson's drug screening pipeline with
our lab and The Parkinson's Institute, June 12, 2006
• Press Release, Howard Hughes Medical Instiute, story on new discovery in Science
magazine on Parkinson's Disease, June 22, 2006
• The New York Times, story on our new discovery in Science magazine on Parkinson's
Disease, June 22, 2006
• Forbes, story on new discovery in Science magazine on Parkinson's Disease, June 22, 2006
• New Scientist, story on our new discovery in Science magazine on Parkinson's Disease,
June 22, 2006
• Nature, story on new discovery in Science magazine on Parkinson's Disease, June 22, 2006
• Howard Hughes Medical Institute Bulletin, August 2006 issue, feature story about
JOSHUA and undergraduate science journals
• Howard Hughes Medical Institute Bulletin, November 2006 issue, feature story about
our discovery in Science magazine on Parkinson's Disease
Television Appearances and Press Conferences:
• WIAT-TV, CBS 42, Birmingham, CBS affiliate, 10 PM News
Feature story on my research, June 5, 2000
• WJRD, Tuscaloosa, 10 PM News
Feature story on my research, June 22, 2000
• WVUA Cable TV 34, Tuscaloosa
Feature story on my research, July 2000
• Great Day Tuscaloosa!
Invited guest on television talk show to discuss my research, January 26, 2001
• ABC33/40, Birmingham, ABC affiliate, 5 PM, 6 PM, and 10 PM News
Feature story on my research and the Human Genome Project, February 12, 2001
• Press Conference, Alabama State House, Montgomery
ABC/CBS/NBC/FOX-TV and National Satellite link
March of Dimes Birth Defects Foundation National Press Conference, February 28, 2001
• Research! America 2002 Science/Media Forum, invited panelist for Washington, D.C.-
based biomedical lobby-sponsored program. Hosted by Jim Hartz (NBC Today Show).
Participants included all 4 major networks and National Public Radio, April 22, 2002
• Great Day Tuscaloosa!
Invited guest on television talk show to discuss my research into Parkinson's
Disease, June 2, 2001
• FOX 6, Birmingham Fox TV affiliate, 5 and 9PM news, full-feature story
"Against All Odds" on my research by news anchor Andrea Lindenberg,
November 26, 2002
• ABC 33/40TV Birmingham, ABC affiliate, 5 PM and 10 PM News
Feature story on major medical discovery involving our research, Jan. 29, 2003
• WIAT CBS42 Birmingham, CBS affiliate, 5 PM, 6 PM, and 10 PM News
Feature story on major medical discovery involving my research, Jan. 30, 2003
• WUVA7 Tuscaloosa, 5 PM News
Feature story on major medical discovery involving my research, Jan. 31, 2003
• WAKA-CBS, Montgomery-Selma, CBS affiliate, Feature story on major medical
discovery involving my research, 10:00PM News, Feb. 3, 2003
• Great Day Tuscaloosa!
Invited guest on television talk show to discuss my research into epilepsy; Aug. 4, 2003
• Press Conference, American Society for Cell Biology, 43rd International Meeting,
San Francisco, CA, Dec. 14, 2003. Feature story for media release on our research
• FOX6, Birmingham Fox TV affiliate, 6 PM News, feature story on our research, Oct. 22,
2004
• WUVA7 Tuscaloosa, 5 PM News
Feature story on high school science outreach program that I started with Paul
W. Bryant High School
• NBC13, Birmingham, NBC affiliate, story on my research into Parkinson's
disease, April 14, 2005
• FOX 6, Birmingham Fox TV affiliate, 5 PM news, full-feature story on my
research into Parkinson's disease, April 15, 2005
• Several feature stories on my Alabama Professor of the Year award all appeared
in the television media: NBC, ABC, FOX, CBS affiliates, as well as on WVUA.
November 17, 2005
• The Mike Shula Show, feature story about my Alabama Professor of the Year
Award. WUVA, November 21, 2005.
• CBS TV, WIAT, Birmingham, 10PM newscast story on new Parkinson's drug
screening pipeline with our lab and The Parkinson's Institute, May 7, 2006
• NBC13, Birmingham, NBC affiliate, story on my research into Parkinson's
disease, June 22, 2006
• University of Alabama National Television Commercial, "Crimson is….",
shown nationally on ESPN, CBS, and all local network affiliates