Primary Department Affiliation: Vision Sciences
The research interests of the Gross Lab are mainly focused on the GPCR rhodopsin-mediated retinal degenerations and molecular mechanisms of photoreceptor membrane biogenesis; in particular, the molecular interactions necessary for formation of healthy photoreceptors. Studies are currently focused on understanding those interactions that are defective when rhodopsin lacks the proper structure at its carboxy-terminus, as is the case in several of most forms of the blinding disease autosomal dominant retinitis pigmentosa. Knock-in mice and transgenic Xenopus laevis bearing rhodopsin carboxy-terminal mutations are being used and new ones constructed to aid in the detection of binding partners to the C-terminus of rhodopsin implicated in rhodopsin trafficking.
Research Focus: GPCR trafficking and neuronal degeneration
Research Interests: Rhodopsin-mediated retinal degenerations, protein-protein interactions, cellular development
Secondary Appointments: Cell Biology, Biochemistry and Molecular Genetics, Neurobiology
Lab Members: Dr. Xiaogang Cheng, Research Associate; T.J. Hollingsworth, Vision Science Graduate Student; Joshua Sammons, Cell Molecular Biology Graduate Student, Nicholas Reish, MSTP/ Neurobiology Graduate Student