James Meador-Woodruff, M.D.

Primary Department Affiliation: Psychiatry and Behavioral Neurobiology
Primary Research Area: Psychiatric Disorders

Research, Professional Experience, and Honors:

Postdoctoral Fellow (S. Watson and H. Akil), Mental Health Research Institute, University of Michigan, 1985-1989.

American College of Neuropsychopharmacology/Mead Johnson Travel Fellowship, 1986.

The Lilly Psychiatric Research Fellowship, 1989.

The American Psychiatric Association/Dista Products Resident Research Award, 1989.

Lecturer (1989); Assistant Professor (1990-95); Associate Professor (1995-02), Department of Psychiatry, Univ. Michigan.

Research Investigator (1990-1993); Assistant Research Scientist (1993-1995); Associate Research Scientist (1995-1997); Senior Associate Research Scientist (1997-2002); Senior Research Scientist (2002-2003), Mental Health Research Institute, U Michigan.

NIMH Research Scientist Development Award, 1990-1995.

The A. E. Bennett Award, 1991.

Board Certification in Psychiatry (American Board of Psychiatry and Neurology), 1991.

Collegium Internationale Neuro-Psychopharmacologicum (CINP) Rafaelsen Fellowship Award, 1992.

Young Investigator Award, International Congress on Schizophrenia Research, 1993.

NIH, NIMH, NIGMS, and Department of Veterans Affairs, grant reviewer, 1994--

American College of Neuropsychopharmacology, elected as Member, 1995; promoted to Fellow, 2002.

NIH Reviewers Reserve, 1995--

Associate Editor, Schizophrenia Bulletin, 1995--

Editorial Board, Neuropsychopharmacology, 1997-1999

Editorial Advisory Board, Journal of Neural Transmission, 1998--

Research Advisor, Department of Psychiatry, Ann Arbor VAMC, 1995-1999

Director of Psychiatric Research, Department of Psychiatry, Ann Arbor VAMC, 1999--

Editor, ACNP Scientific Website, 1999-

Director of Residency Research Track, Department of Psychiatry, University of Michigan, 2000-

Interim Associate Chair for Research, Department of Psychiatry, University of Michigan, 2001-2002

Associate Chair for Research Training and Faculty Development, Department of Psychiatry, Univ. of Michigan, 2001-2002

Professor, Department of Psychiatry, University of Michigan, 2002--

Associate Chair for Research, Department of Psychiatry, Univ. of Michigan, 2002-

Research Professor, Mental Health Research Institute, University of Michigan, 2003-

Vice Chair, Department of Psychiatry, Univ. of Michigan, 2004-

Representative Publications (from a list of 145 papers):

Meador-Woodruff JH, Damask SP, Watson SJ: Differential Expression of Autoreceptors in the Ascending Dopamine Systems of the Human Brain. Proceedings of the National Academy of Sciences USA. 91: 8297-8301, 1994.

Meador-Woodruff JH, Haroutunian V, Powchik P, Davidson M, Davis KL, Watson SJ: Dopamine Receptor Transcript Expression in Striatum, Prefrontal and Occipital Cortex. Archives of General Psychiatry. 54: 1089-1095, 1997.

Dalack GW, Healy DJ, Meador-Woodruff JH: Nicotine Dependence in Schizophrenia: Clinical Phenomena and Laboratory Findings. American Journal of Psychiatry. 155: 1490-1501, 1998.

Ibrahim H, Hogg AJ, Healy DJ, Haroutunian V, Davis KL, Meador-Woodruff JH: Ionotropic Glutamate Receptor Binding and Subunit mRNA Expression in Thalamic Nuclei in Schizophrenia. Am. J. Psychiatry. 157: 1811-1823, 2000.

Meador-Woodruff JH, Hogg AJ, Smith RE: Striatal Ionotropic Glutamate Receptor Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. Brain Research Bulletin. 55: 631-640, 2001.

Meador-Woodruff JH, Davis KL, Haroutunian V: Abnormal Kainate Receptor Expression in Prefrontal Cortex in Schizophrenia. Neuropsychopharmacology. 24: 545-552, 2001.

Smith RE, Haroutunian V, Davis KL, and Meador-Woodruff JH: Expression of Excitatory Amino Acid Transporter Transcripts in the Thalamus in Schizophrenia. American Journal of Psychiatry. 158: 1393-1399, 2001.

Ritter LM, Unis AS, and Meador-Woodruff JH: Ontogeny of Ionotropic Glutamate Receptor Expression In Human Fetal Brain. Developmental Brain Research. 127: 123-133, 2001.

McCullumsmith RE and Meador-Woodruff JH: Striatal Excitatory Amino Acid Transporter Transcript Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. Neuropsychopharmacology. 26: 368-375, 2002.

Smith RE, Haroutunian V, Davis KL, and Meador-Woodruff JH: Vesicular Glutamate Transporter Transcript Expression in the Thalamus in Schizophrenia. NeuroReport. 12: 1-3, 2001.

Clinton SM and Meador-Woodruff JH: Nucleus-Specific Expression of NMDA Receptor-Associated Postsynaptic Density Proteins in Primate Thalamus. Thalamus and Related Systems. 1: 303-316, 2002.

Ritter LM, Vazquez DM, and Meador-Woodruff JH: Ontogeny of Ionotropic Glutamate Receptor Subunit Expression in the Rat Hippocampus. Developmental Brain Research. 139: 227-236, 2002.

Clinton SM, Haroutunian V, Davis KL, and Meador-Woodruff JH: Altered Transcript Expression of NMDA Receptor-Associated Postsynaptic Proteins in the Thalamus of Subjects with Schizophrenia. American J Psychiatry. 160: 1100-1109, 2003.

McCullumsmith RE, Stincic TL, Agrawal SM, Meador-Woodruff JH: Differential Effects of Antipsychotics on Haloperidol-Induced Vacuous Chewing Movements and Subcortical Gene Expression in the Rat. Eur J Pharmacology. 477: 101-112, 2003.

Ritter LM, Meador-Woodruff JH, and Dalack GW: Neurocognitive Measures of Frontal Cortical Dysfunction in Schizophrenia. Schizophrenia Research. 68: 65-73, 2004.

Meador-Woodruff JH, Clinton SM, Beneyto M, and McCullumsmith RE: Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia. Annals of the New York Academy of Sciences. In press.

Evans SJ, Choudary PV, Vawter MP, Li J, Meador-Woodruff JH, Lopez JF, Burke SM, Thompson RC, Myers RM, Jones EG, Bunney WE, Watson SJ, and Akil H: DNA Microarray Analysis of Functionally Discrete Human Brain Regions Reveals Divergent Transcriptional Profiles. Neurobiology of Disease. 14: 240-250, 2003.

Meador-Woodruff JH, Clinton SM, Beneyto M, and McCullumsmith RE: Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia. Annals of the New York Academy of Sciences. 1003: 75-93, 2003.

Clinton SM and Meador-Woodruff JH: Thalamic Dysfunction in Schizophrenia: Neurochemical, Neuropathological, and In Vivo Imaging Abnormalities. Schizophrenia Research. 69: 237-253, 2004.

Beneyto M and Meador-Woodruff JH: Expression of Transcripts Encoding AMPA Receptor Subunits and Associated Postsynaptic Proteins in the Macaque Brain. Journal of Comparative Neurology. 468: 530-554, 2004.

Oakman SA, Meador-Woodruff JH: Calcyon Transcript Expression in Macaque Brain. J Comp Neurology. 468: 264-276, 2004.

Davidkova G, McCullumsmith RE, and Meador-Woodruff JH: Expression of ARHGEF11 mRNA in Schizophrenic Thalamus. Annals of the New York Academy of Sciences. 1003: 375-377, 2003.

Beneyto M and Meador-Woodruff JH: AMPA and NMDA Associated Postsynaptic Protein Expression in Human Dorsolateral Prefrontal Cortex. Annals of the New York Academy of Sciences. 1003: 352-355, 2003.

Mueller HT and Meador-Woodruff JH: Expression of the NR3A Subunit of the NMDA Receptor in Human Fetal Brain. Annals of the New York Academy of Sciences. 1003: 448-451, 2003.

McCullumsmith RE, and Meador-Woodruff JH: Expression of Transcripts for the Vesicular Glutamate Transporters in the Human Medial Temporal Lobe. Annals of the New York Academy of Sciences. 1003: 438-442, 2003.

Mueller HT, Haroutunian V, Davis KL, and Meador-Woodruff JH: Expression of the Ionotropic Glutamate Receptor Subunits and NMDA Receptor-Associated Intracellular Proteins in the Substantia Nigra in Schizophrenia. Mol Brain Res. 121: 60-69, 2004.

Knable MB, Barci BM, Webster MJ, Meador-Woodruff JH, and Torrey EF: Molecular Abnormalities of the Hippocampus in Severe Psychiatric Illness: Postmortem Findings from the Stanley Foundation Neuropathology Consortium. Molecular Psychiatry. 9: 609-620, 2004.

McCullumsmith RE, Semins MJ, and Meador-Woodruff JH: Effects of 6-cyano-7-nitroquinoxaline-2,3-dione on Nicotinic Receptor Subunit Transcript Expression in the Rat Brain. Synapse. 52: 62-72, 2004.

Clinton SM, Abelson S, Haroutunian V, Davis K, and Meador-Woodruff JH: Neurofilament Subunit Protein Abnormalities in the Thalamus in Schizophrenia. Thalamus and Related Systems. 2: 265-272, 2004.

Mueller HT and Meador-Woodruff JH: NR3A NMDA Receptor Subunit mRNA Expression in Schizophrenia, Depression and Bipolar Disorder. Schizophrenia Research. In press.

Clinton SM and Meador-Woodruff JH: Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder. Neuropsychopharmacology. 29: 1353-1362, 2004.

Vawter MP, Evans S, Choudary P, Tomita H, Meador-Woodruff JH, Molnar M, Li J, Lopez JF, Myers R, Cox D, Watson SJ, Akil H, Jones EG, and Bunney WE: Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes. Neuropsychopharmacology. 29: 373-384, 2004.

Research Projects Ongoing or Completed in the Last 3 Years:

Ongoing:

NIMH, #R01 MH53327. "Glutamate Synapse Abnormalities in Schizophrenic Cortex." James H. Meador-Woodruff, M.D., Principal Investigator. 3/9/01-2/28/06. This grant focuses on expression of glutamate receptors and transporters in prefrontal cortex of the postmortem schizophrenic brain.

NIMH, #R25 MH63742. "Mental Health Education Grant (R25)." James H. Meador-Woodruff, M.D., Principal Investigator. 7/1/01-6/30/06. This is a training grant for research-oriented psychiatry residents at Michigan for a program directed by Dr. Meador-Woodruff.

NIMH, #F31 MH65010. "NR3 Expression in Human Brain." Predoctoral fellowship for Helena T. Mueller, James H. Meador-Woodruff, M.D., Sponsor. 9/28/01-9/27/04. This is a predoctoral fellowship for a graduate student in Dr. Meador-Woodruff's lab.

Pfizer Postdoctoral Fellowship Program. "A study of Glutamatergic Corticothalamic Circuitry in Schizophrenia." Postdoctoral fellowship for Robert McCullumsmith, M.D., Ph.D. , James H. Meador-Woodruff, M.D., Sponsor. 7/1/02-6/30/05. This is a fellowship for a postdoctoral fellow in Dr. Meador-Woodruff's lab.

NIMH, "Myelin Gene Products in Postmortem Tissue." Mt. Sinai Medical Center Conti Center renewal, Kenneth L. Davis, M.D., Principal Investigator. 7/1/02-6/30/07. This is a subcontract to study glial abnormalities in postmortem brain samples in schizophrenia.

Completed in Last 3 Years:

NIMH, #R01 MH53327. "Cortical-Subcortical Circuits in Schizophrenic Brain." James H. Meador-Woodruff, M.D., Principal Investigator. 7/1/95-3/8/01. This grant focused on dopamine and glutamate receptor transcript expression in schizophrenic brain.

Lilly Research Laboratories. "Amelioration of VCMs by Olanzapine in a Rodent Model of TD." James H. Meador-Woodruff, M.D., Principal Investigator. 10/1/00-3/31/02. This project examined behavioral and gene expression changes in an animal model of tardive dyskinesia.

The Pritzker Foundation. "Pritzker Neuropsychiatric Disorders Research Consortium." (James H. Meador-Woodruff, M.D., participating investigator from 12/1/00-1/31/03). Project period 12/1/00-11/30/05. This is a multi-site consortium focused on large scale gene expression studies in the brain in severe mental illness.