Primary Department Affiliation: Neurobiology
Primary Research Area: Learning, Memory, and Synaptic Plasticity;
Neurodegeneration and Neurodegenerative Disorders;
Neurotransmitter and Neurotrophin Receptors and Cell Signaling;
Ion Channels and Synaptic Function;
Neurodevelopment and Developmental Disabilities
VISIT THE LAB http://www.lubinlab.com
Research in the Lubin lab focuses on transcriptional mechanisms shown to regulate cellular and molecular processes relevant to synaptic plasticity and learning and memory formation. Chromatin modifiers regulate gene transcription changes in neurons in order to convey information about the environment or experiences of an individual. The lab takes a broad-based approach to understanding the process of learning and memory formation by defining the mechanisms of molecular chromatin restructuring, studying the neurons that express epigenetic modifiers, and determining the roles of these novel transcriptional molecular and neural mediators on chromatin structure in vivo and on behavioral responses. Current work also includes an assessment of histone demethylation inhibitors and agents that may be promising in the mitigation or disruption of cognitive changes that occur with neurological disorders such as Alzheimer’s Disease and epilepsy.