Guy Caldwell, Ph.D.


Adjunct Assistant Professor


Primary Department Affiliation
: Biological Sciences

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 205.348.9926
Fax: 205.348.1786

Recent Publications

 

Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006)



BIOGRAPHICAL SKETCH

NAME

Guy Alexander Caldwell

eRA COMMONS USER NAME

guycaldwell

POSITION TITLE

Associate Professor of Biological Sciences

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


INSTITUTION AND LOCATION DEGREE

(if applicable) YEAR(s) FIELD OF STUDY

Washington & Lee University Lexington, VA B.S. 1981-1986 Biology

The University of Tennessee Knoxville, TN Ph.D. 1986-1993 Cell & Molecular Biology

Columbia University New York, NY Postdoctoral 1995-1999 Neurogenetics


A. Positions and Honors

Positions Held

1985-1986 Research Assistant, Department of Biology, Washington & Lee University

1986-1987 Research Intern in Molecular Genetics, Burroughs-Wellcome Co., Research Triangle Park, NC

1987-1990 Graduate Teaching Assistant, Dept. Microbiology, The University of Tennessee

1990-1993 Graduate Research Assistant, Dept. Microbiology, The University of Tennessee

1995-1996 Lecturer, Cell Biology, The University of Tennessee

1995-1999 Postdoctoral Research Fellow, Columbia University, Sponsor: Martin Chalfie

1999-2005 Assistant Professor of Biological Sciences, The University of Alabama

2003- Faculty Affiliate, Center for Mental Health & Aging, The University of Alabama

2003- Faculty Member, Center for Green Manufacturing, The University of Alabama

2004- Adjunct Research Asst. Professor, Dept. Neurology, Univ. Alabama at Birmingham (UAB)

2005- Associate Professor of Biological Sciences, The University of Alabama

2007- Scientist, Center for Experimental Therapeutics and Neurodegeneration, UAB

2007- Adjunct Associate Professor, Dept. Neurobiology, UAB

Honors

1983-1986 Robert E. Lee Research Scholarship, Washington & Lee University

1988-1993 Science Alliance Research Achievement Award, Oak Ridge National Lab - U. Tennessee

1992 American Society for Cell Biology Student Travel Award

1995-1998 NRSA Postdoctoral Fellowship, NINDS, 1st percentile rank

2001-2003 Basil O'Connor Scholar of The March of Dimes Birth Defects Foundation

2003- CAREER Award Recipient, National Science Foundation

2005- Leadership Board Fellow, The University of Alabama, College of Arts & Sciences

2005 Howard Hughes Medical Institute Investigator, Nominee

2005 Carnegie Foundation and CASE U.S. Professor of The Year, State of Alabama

Memberships

American Society for Cell Biology

American Association for the Advancement of Science

American Epilepsy Society

International Brain Research Organization

Movement Disorders Society

Society for Neuroscience

Genetics Society of America

B. Selected publications

Textbooks Authored

Becker, J. M., Caldwell, G.A., and Zachgo, E. A. (1990) Biotechnology: A Laboratory Course. Academic Press, Inc.

Harcourt Brace Jovanovich Publishers), San Diego (textbook, 232 pages) [Chinese edition also]

Becker, J.M., Caldwell, G.A., and Zachgo, E.A. (1996) Biotechnology: A Laboratory Course, 2nd Edition. Academic

Press, Inc. (Harcourt Brace Publishers), San Diego (textbook, 250 pages) [Spanish edition also]

Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006)

Caldwell, G.A., Williams, S.N., and Caldwell, K.A. (2006) Integrated Genomics: A Discovery-based Laboratory

Course. (Wiley), Chichester, U.K. (textbook, 225 pages)

Book Chapters

Caldwell, G.A., Cao, S., Izevbaye, I., and Caldwell, K.A. (2005) "Use of C. elegans to Model Human Movement Disorders"

In Animal Models of Movement Disorders (LeDoux, M., ed.) Elsevier, New York, pp. 113-128

Baumeister, R., Säman, J., Caldwell, K.A., and Caldwell, G.A. (2007) "Investigating Alzheimer's and Parkinson's Disease

using C. elegans" In Wormbook (Chalfie, M., ed.). in press

Journal Articles

Marcus, S., Caldwell, G.A., Xue, C.-B., Naider, F. and Becker, J.M. (1990) "Total in vitro Maturation of the S. cerevisiae

a-factor Lipopeptide Mating Pheromone". Biochem. Biophys. Res. Comm. 172:1310-1316.

Marcus, S., Caldwell, G.A., Miller, D., Xue, C.-B., Naider, F., and Becker, J.M. (1991) "Significance of C-terminal

Cysteine Modifications to the Biological Activity of Saccharomyces cerevisiae a-factor Mating Pheromone". Mol. Cell.

Biol. 11:3603-3612.

Caldwell, G.A., Wang, S-H., Dawe, A.L., Becker, J.M. and Naider, F. (1993) "Identification of a Hyperactive Mating

Pheromone of Saccharomyces cerevisiae". Biochem. Biophys. Res. Comm. 197:1173-1178.

Ben-Yaacov, R., Knoller, S., Caldwell, G.A., Becker, J., and Koltin, Y. (1994) "Candida albicans Gene Encoding

Resistance to Benomyl and Methotrexate is a Multidrug Resistance Gene". Antimicrob. Agents Chemother.

38:648-652.

Caldwell, G.A., Wang, S.-H., Lu, H.-F., Naider, F., and Becker, J.M. (1994) "Molecular Determinants of the Bioactivity of

the Saccharomyces cerevisiae Lipopeptide Mating Pheromone". J. Biol. Chem. 269:19817-19826.

Caldwell, G.A., Wang, S.-H., Naider, F., and Becker, J.M. (1994) "Consequences of Altered Isoprenylation Targets on afactor

Export and Bioactivity". Proc. Natl. Acad. Sci. USA. 91:1275-1279.

Caldwell, G.A., Naider, F. and Becker, J.M. (1995) "Fungal Lipopeptide Mating Pheromones: A Model System for the

Study of Protein Prenylation" Microbiol. Rev. 59:406-422.

Gu, G., Caldwell, G.A., and Chalfie, M. (1996) "Genetic Interactions Affecting Mechanosensation in C. elegans."

Proc. Natl. Acad. Sci. USA. 13:6577-6582.

Dawe, A. L., Caldwell, K.A., Harris, P.M., Morris, N.R., and Caldwell, G.A. (2001) "Evolutionarily conserved nucelar

migration genes required for early embryonic development in C. elegans". Dev. Genes Evol. 211:434-441.

Caldwell G.A., Cao S., Sexton E.G., Gelwix C.C., Bevel J.P., and Caldwell K.A. (2003) "Suppression of polyglutamineinduced

protein aggregation in Caenorhabditis elegans by torsin proteins." Hum. Mol. Genet. 12:307-319.

Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A., Lin, S-H., Yu-Lee, L. (2003) "A Role for

NudC, a Dynein-Associated Nuclear Movement Protein, in Mitosis and Cytokinesis" J. Cell Sci. 116:1991-2003.

Swatloski, R.P. Rogers, R.D., Holbrey, J.D., Turner, M.B., Memon, S.B. Caldwell, G.A. and Caldwell, K.A., (2004) "Using C.

elegans to Probe Toxicity of 1-alkyl-3-methylimidazolium Chloride Based Ionic Liquids" Chem. Comm. 6:689-690.

Caldwell, G.A., Cao, S., Gelwix, C.C., Sexton, E.G., and Caldwell, K.A. (2004) "An Animal Model to Discern Torsin Function:

Suppression of Protein Aggregation in C. elegans" Adv. Neurol. 94:79-85.

Williams, S.N., Locke, C.J., Braden, A.L., Caldwell, K.A., and Caldwell, G.A. (2004) "Epileptic-like convulsions associated

with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans" Hum. Mol. Genet.

13:2043-2059.

Zhang, S., Keller, C.A., Yao, C. A., Caldwell, G.A.,Chalfie, M. (2004) "MEC-2 is recruited to the putative mechanosensory

complex in C. elegans touch receptor neurons through its stomatin-like domain," Curr. Biol.14:1888-1896.

Cao S., Gelwix C.C., Caldwell K.A. and Caldwell G.A. (2005) "Torsin-mediated protection from cellular stress in the

dopaminergic neurons of C. elegans" J. Neurosci. 25:3801-12.

Dickey, C.A., Dickson, D., Yue, M., Lin, W-L., Dunmore, J., West, G., Patterson, C., Cao, S., Clark, A.M.K., Caldwell,

G.A., Caldwell, K.A., Eckman, C., Hutton, M., and Petrucelli, L. (2005) "Deletion of CHIP leads to caspase-3 activation

and neuronal apoptosis associated with increases in non-ubiquitinated, soluble phospho-tau species without

neurofibrilary tangles. J. Neurosci. 26:6985-6996.

Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K., Xu, K., Strathearn, K.E., Liu, F., Cao,

S., Caldwell, K.A., Caldwell, G.A., Kolodner, R.D., Marsischky, G., LaBaer, J., Rochet, J-C., Bonini, N.M., and

Lindquist, S. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 Rescues Neuron Loss in Parkinson's Models.

Science, 313:324-328.

Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006)

Locke, C.J., Williams, S.N., Schwarz, E.M., Caldwell, G.A., and Caldwell, K.A. (2006) "Genetic Interactions Among

Cortical Malformation Genes that Influence Susceptibility to Convulsions" Brain Research, 1120:23-34.

C. Research Support

ACTIVE

No number specified (G. Caldwell and K. Caldwell) 1/1/2007-12/31/2007

Bachmann-Strauss Dystonia & Parkinson Foundation

Identification Chemical Modifiers of Torsin Activity

The major goals of this study are aimed at identifying new chemical modifiers of torsinA activity using C. elegans. Positive

hits will be shared with researchers at The Broad Institute and Harvard to study potential binding to torsinA and efficacy of

specific hits in dystonia patient fibroblasts.

Role: Co-Principal Investigator

No Number Specified (G. Caldwell and K. Caldwell) 1/1/2007-8/31/2007

FoldRx Pharmaceuticals

Small Molecule Testing for Neuroprotective Compounds Associated with Parkinson's Disease

The major goals of this study are aimed at investigating the potential of specific small molecule modifiers of alphasynuclein

neurodegeneration in C. elegans.

Role: Co-Principal Investigator

237956 (G. Caldwell) 7/1/2003- 6/30/2008

NSF/CAREER Award

CAREER: An Integrated Discovery-Based Genomic Approach to Discerning the Role of Nuclear Positioning Genes in

Neurodevelopment

This represents a combination teaching/research grant designed to support young faculty who design career plans that

integrate research into innovative curricula. The research aspects of this award focus on gene products associated with

cytoskeletal control of nuclear migration and its impact on neurodevelopment.

1R21ES014426-01 (G. Caldwell) 1/1/2006-12/31/2007

NIH/NIEHS

Use of C. elegans to Explore Bacterial Sources of Toxicity in Parkinson's Disease

The major goals of this exploratory project are to investigate the prospect of bacterial sources of neurotoxins that may

contribute to the development of Parkinson's disease.

Role: Principal Investigator

No number specified (D.G. Standaert, K. Caldwell, and G. Caldwell) 07/01/2007-06/30/2009

Michael J. Fox Foundation for Parkinson's Research

Validation of VPS41, a protein involved in lysosomal trafficking, as a target for Parkinson disease therapy

This collaborative investigation with Dr. David Standaert at UAB involves target validation in mouse and cell culture

models of a gene that we have identified as being neuroprotective against dopaminergic neurodegenration induced by

overexpression of human alpha-synuclein in C. elegans.

Role: Co-Principal Investigator

No number specified (G. Caldwell) 07/01/2007-06/30/2008

American Parkinson Disease Association

Identification and Functional Validation of Neuroprotective Genes Associated with Parkinson's Disease

The major goals of this study are aimed at investigating the potential for specific genes we have previously identified as

affecting human alpha-synuclein misfolding and their capacity for functioning as neuroprotective proteins in dopamine

neurons.

Role: Principal Investigator

OVERLAP

There is no overlap between this NIH grant submission and any of the pending support listed above.

Principal Investigators/Program Director (Last, First, Middle): Caldwell, Guy A.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006)

COMPLETED (past 3 years)

No number specified (G. Caldwell and K. Caldwell) 1/1/2006-12/31/2006

Bachmann-Strauss Dystonia & Parkinson Foundation

Examining the Neuroprotective Capacity of Novel Gene Targets Associated with Parkinson's Disease

The major goals of this project were to validate gene targets isolated from RNAi screening for genetic effectors of alphasynuclein

misfolding. This work identified 4 neuroprotective genes previously unassociated with Parkinson's.

Role: Co-Principal Investigator

No number specified (G. Caldwell and K. Caldwell) 3/1/2006-02/28/2007

The Parkinson's Institute

STOP-PD Program

This contract represented a collaboration between our lab and those of chemist, Dr. Anthony Fink (UC-Santa Cruz), and

neurologist, Dr. J. William Langston (Director, The Parkinson's Institute), with whom we have formed a new drug

screening "pipeline" (from test tubes to worms to rodents to primates to human clinical trials) for small molecule

therapeutics designed to protect dopamine neurons from toxic expression of human alpha-synuclein. This project is

currently on hold as development of mouse and primate models continues.

Role: Co-Principal Investigator

0403081 (G. Caldwell, J. O'Donnell, E. Stephenson) 1/1/2005-12/31/2006

NSF/Multi-user Equipment Grant

Confocal Microscopes for The University of Alabama Optical Analysis Facility

This was an equipment grant funded to purchase a new confocal microscope.

Role: Co-Principal Investigator

0500766 (G. Caldwell, H. Smith-Somerville, M. Powell) 06/01/2005-05/31/07

NSF/Multi-user Instrumentation Grant

Transmission Electron Microscopy for The University of Alabama Optical Analysis Facility

This was an equipment grant designed to upgrade an older existing TEM device in our department.

Role: Co-Principal Investigator

No number specified (G. Caldwell and K. Caldwell) 1/1/2005-12/31/2005

Dystonia Medical Research Foundation

Chemical screening for torsin effectors in C. elegans

The major goals of this project were to perform a medium throughput small molecule screen for compounds that affect the

activity of torsin proteins, as they malfunction in a nematode model of early-onset dystonia. One of these molecules is

now going to human clinical trials.

Role: Co-Principal Investigator

No number specified (G. Caldwell and K. Caldwell) 1/1/2005-12/31/2005

Bachmann-Strauss Dystonia & Parkinson Foundation

Proteomic Analysis of Torsin Effectors & Functional Interactions Pertaining to Dystonia

The major goals of this project were to identify effectors of torsin-related proteins using proteomic methods. This work

was also aimed at probing the potential molecular relationships between different forms of dystonia.

Role: Co-Principal Investigator

No number specified (G. Caldwell) 01/01/03-12/31/2004

Michael J. Fox Foundation for Parkinson's Research

RNAi Screening and Analysis of Factors Influencing ER-Associated Degradation and Alpha-Synuclein Aggregation in C.

elegans.

This grant funded a combination of bioinformatics/genomic-scale RNAi screening approach toward discerning novel

genetic susceptibility factors and therapeutic targets for Parkinson's disease.

Role: Principal Investigator

1 R15 NS043176 (G. Caldwell) 2/1/2003-7/31/2006

NIH/NINDS

This AREA grant supported initial studies into the function of the torsin family of proteins and their relationship to earlyonset

torsion dystonia, a human movement disorders. These studies established C. elegans as a model system wherein

torsin activity could be evaluated.

Role: Principal Investigator

GUY A. CALDWELL, Ph.D.

Associate Professor of Biological Sciences

The University of Alabama

Department of Biological Sciences

P.O. Box 870344

Tuscaloosa, AL 35487-0344

Education:

Washington and Lee University, B.S. in Biology, 1986 (cum laude)

The University of Tennessee, Ph.D. in Cell and Molecular Biology, 1993; Jeffery Becker, mentor

Columbia University, Postdoctoral Fellow, 1995-1999; Martin Chalfie, sponsor

Professional Experience:

Graduate Teaching Assistant, Dept. of Microbiology, University of Tennessee, 1987-1990

Graduate Research Assistant, Dept. of Microbiology, University of Tennessee, 1990-1993

Postdoctoral Research Scientist, University of Tennessee, 1994, Jeffrey Becker, sponsor

Postdoctoral Research Fellow, Columbia University, 1995-1999; Martin Chalfie, sponsor

Assistant Professor, Dept. Biological Sciences, The University of Alabama, 1999-2005

Faculty Affiliate, Center for Mental Health and Aging, The University of Alabama, 2003-present

Faculty Member, Center for Green Manufacturing, The University of Alabama, 2003-present

Adjunct Research Professor of Neurology, University of Alabama at Birmingham, 2004-present

Associate Professor, Dept. Biological Sciences, The University of Alabama, 2005-present

Scientist, Center for Experimental Therapeutics and Neurodegeneration,

University of Alabama at Birmingham, 2007-present

 

Honors:

Science Alliance Research Achievement Award Recipient, U. Tennessee, 1988, 1990-93

National Research Service Postdoctoral Fellowship Grant,

National Institute of Neurological Disease and Stroke, 1995-1998, 1st percentile rank

Howard Hughes Medical Institute Undergraduate Science Program Faculty Appointee

The University of Alabama, 1999-2003

Basil O'Connor Scholar of the March of Dimes Birth Defect Foundation, 2001

Blount Undergraduate Initiative Fellow, The University of Alabama, 2001

Honorary Member of the Golden Key International Honor Society, 2003

CAREER Award Recipient, National Science Foundation, 2003-2008

Honorary Member, The Anderson Society, The University of Alabama, 2005

Howard Hughes Medical Institute Investigator Nominee, 2004

Who's Who in America, 2005-present

Leadership Board Fellow, UA College of Arts & Sciences, 2005-2008

Carnegie Foundation and Council for the Advancement and Support of Education (CASE),

U.S. Professor of The Year, State of Alabama, 2005

Honorary Member, Omicron Delta Kappa (ODK), 2007

 

Professional Organizations:

American Epilepsy Society

American Society for Cell Biology

American Association for the Advancement of Science

Movement Disorders Society

Society for Neuroscience

International Brain Research Organization

Genetics Society of America

Teaching:

ALL of the following courses have been taught in their entirety by Dr. Caldwell:

Integrated Genomics Laboratory (BSC 442)

Designed, equipped, and taught a new discovery-based undergraduate genomics and

bioinformatics laboratory course:

Taught every spring; 4 credit hours (with Writing component credit)

• A contract has been signed for a textbook based on this course with an

international publisher (Wiley) for release in 2006

Signal Transduction in Neurobiology (BSC 494/BSC 594)

Designed and taught new literature-based undergraduate/graduate lecture course:

Taught every alternate fall semester; 3 credit hours

Decoding Ourselves: The Impact of the Human Genome Project on Science and Society

(BUI 301-001) Designed and taught new undergraduate seminar course (for Blount Program)

Taught Fall 2001; 3 credit hours

• Web-CT site developed for on-line student-monitored (instructor graded)

message board

• cover story of Howard Hughes Medical Institute website, April 2002

• currently taught annually by Dr. Kim Caldwell

Honors General Biology I (BSC118)

Taught introductory biology course for University Honors Program students

Taught every alternate fall semester; 4 credit hours

• designed and used Web-CT module for instruction

Common Book Experience (UHP 120-002)

Designed and taught new undergraduate seminar course for University Honors Program

Taught Fall 2003: 1 credit hour

Current Topics in Nematode Neurobiology (BSC 695)

Designed and taught new graduate seminar course

Taught Spring 2005: 1 credit hour

The Language of Research (BSC 497)

Taught undergraduate course on research culture and literature analysis for Howard

Hughes Research Interns; Lectures alternate between UA and Stillman College.

Taught Spring 2005; 2 credit hours

Independent Study (BSC 391) and Computer-Based Honors (CBH 202) Projects:

Designed and supervised four separate undergraduate projects for credit:

• Analysis of genetic database of several hundred Quicktime video images

of cell division in an attempt to identify novel gene targets related to a

human brain disease termed lissencephaly. Videos from our laboratory

have been requested for an upcoming textbook by Sinauer.

• Use of internet-based genetic databases in collaboration with researchers

at the National Cancer Institute for identification of novel genes termed

NORFs that were possibly missed by the Human Genome Project.

• Analysis of an internet database at Stanford University for profiling of

specific gene expression under different genetic and environmental

conditions using microarray ("gene chip") technology.

• Currently supervising an undergraduate Computer-Based Honors Program

student in the development of a novel bioinformatics database on the genetics of

epilepsy. This represents a unique research resource for the epilepsy

community: http://www.carpedb.ua.edu; published in

and highlighted in Science magazine and Biotechniques.

Grants and Contracts Funded

Dr. Guy Caldwell is the sole P.I. on all grants except where denoted by *

Dystonia Medical Research Foundation

Title: "A Functional Genomic Analysis of Torsin Homologues in C. elegans"

1 yr., $35,000; March 2000-March 2001.

University of Alabama Research Advisory Committee grant

Title: "Expression and Functional Analysis of C. elegans Nuclear Migration Genes"

2 years, $4,700; January 2000-January 2002.

The March of Dimes Birth Defects Foundation: Basil O'Connor Scholar Award

Title: "Cytoskeletal Regulation of Nuclear Migration and Lissencephaly Proteins"

2 years, $150,000; February 2001-February 2003.

Dystonia Medical Research Foundation

Title: "Analysis of Torsin Function in C. elegans"

1 yr., $20,000; Sept. 2001-Sept. 2003.

University of Alabama Research Advisory Committee grant

Title: "Suppression of Parkinson's Disease Related Protein Aggregation by

C. elegans TOR-2" $4,998; Jan. 2002-Jan. 2004.

American Parkinson's Disease Association

Title: ""C. elegans as an Animal Model to Discern the Functional Relationship

Between Torsin and Alpha-Synuclein Proteins in Parkinson's Disease"

$35,000; Sept. 2002-August 2003 (awarded but declined)

Parkinson Disease Foundation and National Parkinson Foundation Joint

Research Grant Program

Title: "C. elegans as an Animal Model to Discern the Functional Relationship

Between Torsin and Alpha-Synuclein Proteins in Parkinson's Disease"

$35,000; June 2002-May 2003

Invitrogen, Inc. Collaborative Research Contract;

$23,000, Sept. 2002-no end date.

Michael J. Fox Foundation for Parkinson's Research

Title: "RNAi Screening and Analysis of Factors Influencing ER-Associated

Degradation and α-Synuclein Aggregation in C. elegans", $145,193; December

2002-2004.

National Institutes of Health

Title: "Analysis of Torsin Protein in C. elegans", $141,000; February 2003-

January 2006.

Center for Mental Health and Aging, The University of Alabama,

Title: "Molecular Analysis of Aging in an Animal Model for Parkinson's

Disease" $3500, 2003

National Science Foundation CAREER Award

Title: "CAREER: An Integrated Discovery-Based Genomic Approach to

Discerning the Role of Nuclear Positioning Genes in Neurodevelopment"

$628,000, July 2003-2008

Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award

Title: "Analysis of Torsin-mediated Protection from Cellular Stress in C. elegans"

Title: "Analysis of Torsin-mediated Protection from Cellular Stress in C. elegans"

$50,000, January 2003-2004 [Co-PI with Dr. Kim Caldwell]*

Dystonia Medical Research Foundation

Title: "Chemical Screening for Torsin Effectors in C. elegans"

$39,000, Jan 2005-2006, [Co-PI with Dr. Kim Caldwell]*

National Science Foundation

Title: "Confocal Microscopes for University of Alabama Optical Analysis

Facility", $298,570, August 1, 2004-2005 [Co-PI with Drs. Janis O'Donnell and

Edwin Stephenson]*

Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award

Title: "Proteomic Analysis of Torsin Effectors & Functional Interactions

Pertaining to Dystonia"

$50,000, January 2005-2006 [Co-PI with Dr. Kim Caldwell]*

National Science Foundation

Title: "Transmission Electron Microscopy for University of Alabama Optical

Analysis Facility", $399,000, funded, start date pending [Co-PI with Drs. Martha

Powell and Harriett Smith-Somerville]*

National Institutes of Health

Title: "Use of C. elegans to Explore Bacterial Sources of Toxicity in Parkinson's

Disease", $294,900, funded, January 2005-December 2007

Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award

Title: "Examining the Neuroprotective Capacity of Novel Gene Targets

Associated with Parkinson's Disease"

$50,000, January 2006-2007 [Co-PI with Dr. Kim Caldwell]*

The Parkinson's Institute, contract award

Title: "STOP-PD Initiative: A Project to Identify a Compound that will Stop, and

Ideally Reverse Parkinson's Disease"

$100,000, March 2005-2006 [Co-PI with Dr. Kim Caldwell]*

FoldRx Pharmaceuticals Inc., contract award

Title: "Compound Testing for Parkinson's Disease"

$8,190, July-September 2006 [Co-PI with Dr. Kim Caldwell]*

Bachmann-Strauss Dystonia & Parkinson Foundation Grant Award

Title: "Investigating Small Molecule Therapeutics for Torsion Dystonia"

$50,000, January 2007-2008 [Co-PI with Dr. Kim Caldwell]*

FoldRx Pharmaceuticals Inc., contract award

Title: "Compound Testing for Parkinson's Disease "

$50,000, January 2007-August 2007 [Co-PI with Dr. Kim Caldwell]*

Michael J. Fox Foundation for Parkinson's Research

Title: "Validation of VPS41, a protein involved in lysosomal trafficking,

as a target for Parkinson disease therapy" July 2007-June 2009 [Co-PI with Dr.

Kim Caldwell and Dr. David Standaert, UAB]*

QRxPharma Ltd., sponsored research agreement

Title: "Drug Development for Neurological Diseases "

$2,000,000, June 2007-June 2012 [Co-PI with Dr. Kim Caldwell]*

Publications:

Textbooks Authored

Becker, J. M., Caldwell, G.A., and Zachgo, E. A. (1990) Biotechnology: A Laboratory

Course. Academic Press, Inc. (Harcourt Brace Jovanovich Publishers), San Diego

[Also published in Chinese]

Becker, J.M., Caldwell, G.A., and Zachgo, E.A. (1996) Biotechnology: A Laboratory

Course, 2nd Edition. Academic Press, Inc. (Harcourt Brace Publishers), San Diego.

[Also published in Spanish]

Caldwell, G.A., Williams, S.N., and Caldwell, K.A. (2006) Integrated Genomics: A

Discovery-based Laboratory Course. Wiley, Chichester, UK.

Book Chapters

Ewenson, A., Xue, C.-B., Marcus, S., Caldwell, G., Becker, J.M., and Naider, F. (1990)

"Synthesis of Biologically Active Analogs of a Lipopeptide Mating Pheromone from

Saccharomyces cerevisiae" In Peptides: Chemistry and Biology (Marshall, G.R., ed.)

Leiden Escom Science Publishers, p. 103-105.

Xue, C.-B., Marcus, S., Caldwell, G., Miller, D., Becker, J.M., and Naider, F. (1991)

"Structure-Activity Relationships of the Saccharomyces cerevisiae a-Mating factor", In

Peptides (Marshall, G.R., ed.) Leiden, The Netherlands: Escom Science Publishers, p.

899-901.

Caldwell, G.A., Cao, S., Gelwix, C.C., Sexton, E.G., and Caldwell, K.A. (2004) "An

Animal Model to Discern Torsin Function: Suppression of Protein Aggregation in C.

elegans" In Advances in Neurology: Dystonia 4 (Fahn, S., Marsden, D., and DeLong,

M., eds). Lippencott, Williams & Wilkens, New York, 94:79-85.

Caldwell, G.A., Cao, S., Izevbaye, I., and Caldwell, K.A. (2005) "Use of C. elegans to

Model Human Movement Disorders" In Animal Models of Movement Disorders

(LeDoux, M., ed.) Elsevier, New York, pp. 111-126.

Baumeister, R., Saman, J., Caldwell, K.A., and Caldwell, G.A. (2006) "Investigating

Alzheimer's and Parkinson's Disease using C. elegans", Wormbook (Chalfie, M., ed.)

in press

Journal Publications

Xue, C.-B., Caldwell, G.A., Becker, J.M., and Naider, F. (1989) "Total Synthesis of the

Lipopeptide a-Mating Factor of Saccharomyces cerevisiae" Biochem. Biophys.

Research Comm. 162:253-257.

Marcus, S., Caldwell, G.A., Xue, C.-B., Naider, F. and Becker, J.M. (1990)

"Total in vitro Maturation of the Saccharomyces cerevisiae a-factor Lipopeptide

Mating Pheromone". Biochem. Biophys. Res. Comm. 172:1310-1316.

Wielgus, J.J., Caldwell, G.A., Nichols, L. and White, C.F. (1990) "The Purification,

Characterization and Fate of a Haemolymph Trophic Factor from the Last Larval Instar

of Manduca sexta". Insect Biochem. 20:65-72.

Marcus, S., Caldwell, G.A., Miller, D., Xue, C.-B., Naider, F., and Becker, J.M. (1991)

"Significance of C-terminal Cysteine Modifications to the Biological Activity of

Saccharomyces cerevisiae a-factor Mating Pheromone". Mol. Cell. Biol. 11:3603-12.

Caldwell, G.A., Wang, S-H., Dawe, A.L., Becker, J.M., and Naider, F. (1993)

"Identification of a Hyperactive Mating Pheromone of Saccharomyces cerevisiae".

Biochem. Biophys. Res. Comm. 197:1173-1178.

Caldwell, G.A. and Becker, J.M. (1993) "Rapid PCR Sequencing of Plasmid DNA

Directly from Colonies of Saccharomyces cerevisiae." Promega Notes 44:6-9.

Ben-Yaacov, R., Knoller, S., Caldwell, G.A., Becker, J., and Koltin, Y. (1994)

"Candida albicans Gene Encoding Resistance to Benomyl and Methotrexate is a

Multidrug Resistance Gene". Antimicrob. Agents Chemother. 38:648-652.

Caldwell, G.A., Wang, S.-H., Naider, F., and Becker, J.M. (1994) "Consequences of

Altered Isoprenylation Targets on a-factor Export and Bioactivity". Proc. Natl. Acad.

Sci. USA. 91:1275-1279.

Caldwell, G.A., Wang, S.-H., Lu, H.-F., Naider, F., and Becker, J.M. (1994)

"Molecular Determinants of the Bioactivity of the Saccharomyces cerevisiae

Lipopeptide Mating Pheromone" J. Biol. Chem. 269:19817-19826.

Caldwell, G.A., Naider, F. and Becker, J.M. (1995) "Fungal Lipopeptide Mating

Pheromones: A Model System for the Study of Protein Prenylation"

Microbiological Reviews 59:406-422.

Gu, G., Caldwell, G.A., and Chalfie, M. (1996) "Genetic Interactions Affecting

Mechanosensation in C. elegans." Proc. Natl. Acad. Sci. USA. 13:6577-6582.

Dawe, A. L., Caldwell, K.A., Harris, P.M., Morris, N.R., and Caldwell, G.A. (2001)

"Evolutionarily conserved nuclear migration genes required for early embryonic

development in Caenorhabditis elegans." Dev. Genes Evol. 211:434-441.

Caldwell, G.A. (2003) "As the Worm Turns: Discovering a Life of Discovery" The

Washington & Lee Journal of Science 4:41-44 (invited review).

Caldwell G.A., Cao S., Sexton E.G., Gelwix C.C., Bevel J.P., and Caldwell K.A. (2003)

"Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans

by torsin proteins." Hum. Mol. Genet. 12(3):307-319. Cover story.

Caldwell, G.A. (2003) "New Insights and Strategies for Treating PolyQ Disorders"

Alzheimer Research Forum (on-line newsletter) http://www.alzforum.org; Feb. 15, 2003

Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A.,

Lin, S-H., Yu-Lee, L. (2003) "A Role for NudC, a Dynein-Associated Nuclear

Movement Protein, in Mitosis and Cytokinesis" J. Cell Sci. 116:1991-2003.

Swatloski, R.P. Rogers, R.D., Holbrey, J.D., Turner, M.B., Memon, S.B. Caldwell, G.A.

and Caldwell, K.A., (2004) "Using Caenorhabditis elegans to Probe Toxicity of 1-

alkyl-3-methylimidazolium Chloride Based Ionic Liquids" Chem. Comm. 6:689-90.

Williams, S.N., Locke, C.J., Braden, A.L., Caldwell, K.A., and Caldwell, G.A. (2004)

"Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of

neurotransmitter signaling in C. elegans" Hum. Mol. Genet., 13:2043-2059.

Zhang, S., Keller, C. A., Yao, C. A., Caldwell, G.A., and Chalfie, M. (2004) "MEC-2 is

recruited to the putative mechanosensory complex in C. elegans touch receptor neurons

through its stomatin-like domain," Curr. Biol. 14:1888-1896.

Cao, S., Gelwix, C.C., Caldwell, K.A., and Caldwell, G.A. (2005) "Torsin-mediated

protection from cellular stress in the dopaminergic neurons of Caenorhabditis

elegans." J. Neurosci. , 25:3801-3812.

Locke, C.J., Caldwell, K.A., and Caldwell, G.A. (2005) "CarpeDB: A comprehensive

database on the genetics of epilepsy" Nucleic Acids Res. 33:D5-24.

Dickey, C.A., Dickson, D., Yue, M., Lin, W-L., Dunmore, J., West, G., Patterson, C.,

Cao, S., Clark, A.K., Caldwell, G.A., Caldwell, K.A., Eckman, C., Hutton, M., and

Petrucelli, L. (2006) "Deletion of CHIP leads to caspase-3 activation and neuronal

apoptosis associated with increases in non-ubiquitinated, soluble phospho-tau species

without neurofibrilary tangles. J. Neurosci. 26:6985-6996.

Cooper, A.A., Gitler, A.D., Cashikar, A., Haynes, C.M., Hill, K.J., Bhullar, B., Liu, K.,

Xu, K., Strathearn, K.E., Liu, F., Cao, S., Caldwell, K.A., Caldwell, G.A.,

Marsischky, G., Kolodner, R.D., , LaBaer, J., Rochet, J-C., Bonini, N.M., and

Lindquist, S. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 Rescues

Neuron Loss in Parkinson's Models. Science, 313:324-328.

Locke, C.J., Williams, S.N., Schwarz, E.M., Caldwell, G.A., and Caldwell, K.A. (2006)

"Genetic Interactions Among Cortical Malformation Genes that Influence

Susceptibility to Convulsions" Brain Research 1120:23-34.

Suessmann, R., Sharma, P., Hajjar, C., Caldwell, K.A., Caldwell, G.A., Du Brueil, R.,

Moore, R., and Boyd, L. "Ubiquitin Conjugating Enzymes Participate in

Polyglutamine Protein Aggregation" submitted to BCM Molecular and Cell Biol.

Patents

Caldwell, G.A. and Caldwell, K.A. "Nucleotide Sequences that Code for Torsin Genes,

Torsin Proteins, and Methods of Using the Same to Treat Protein-Aggregation"

Patent Pending, 16 foreign filings also in review.

Caldwell, G.A. and Caldwell, K.A. "Regulators of Protein Misfolding and Aggregation

and Methods of Using the Same" Patent Pending.

Caldwell, G.A, Caldwell, K.A., Cao, S. "Methods of Using Small Molecule Compounds

for Neuroprotection" Patent Pending.

Consulting:

The Council of Healthcare Advisors, Gerson Lehrman Group (New York, NY), 2001-present

The Science Advisory Board, 2002-present

Scientific Advisory Board, QRxPharma, 2007-present

Grant Reviewer:

Ad-hoc, National Science Foundation, CAREER Award Program, 2003-present

Ad-hoc, National Science Foundation, 2005-2007

Ad-hoc, The Wellcome Trust

Editorial Boards

American Journal of Alzheimer's Disease and Other Dementias, 2004-present

Journal of Opioid Management, 2005-present

Editorial Reviewer/Contributor:

McGraw-Hill Publishers

Harcourt/Elsevier Publishing

John Wiley & Sons Publishers

Ergito Genetics (Benjamin Lewin, on-line publisher)

Benjamin Cummings/Addison Wesley Publishers

The Scientist

Alzheimer's Research Forum

JOSHUA (Journal of Science and Health at the University of Alabama), Faculty Advisor

Journal Reviewer:

Brain Research

Biochemistry

Developmental Brain Research

Genesis, The Journal of Genetics and Development

Genome Research

Human Molecular Genetics

Proceedings of the National Academy of Sciences (PNAS)

Neurobiology of Disease

Neurogenetics

Trends in Parasitology

Neurobiology of Aging

Committees and Miscellaneous Service:

Premier Awards Committee, Member, The University of Alabama, member 2002-2005

Premier Awards Committee, Co-Chair, The University of Alabama, 2006-present

Institutional Biosafety Committee, The University of Alabama, 2000-present

Graduate Committee, Dept. Biological Sciences, The University of Alabama, 2000-2004

Search Committee, Evolutionary-Developmental Biologist, Dept. Biological Sciences,

The University of Alabama, 2003

Search Committee, Associate V.P. for Research, The University of Alabama, 2004

Student Recruitment Advisory Board, The University of Alabama, 2004-present

Graduate Recruitment Committee, UA Dept. Biological Sciences, 2004-present

Workshop & Activities Coordinator, Howard Hughes Medical Institute Undergraduate

Research Intern Program, University of Alabama-Stillman College, 2000-present

Organizer and Lecturer, Human Genome Workshop, co-sponsored with Zeta Phi Beta,

for Tuscaloosa minority community, 2002-2004

Faculty Advisor, UA Chapter of Beta Beta Beta, National Biology Honor Society, 2001-2005

Faculty Advisor, JOSHUA: The Journal of Science and Health at the University of Alabama

Faculty Advisor to 26 undergraduates each semester (for registration, career advice, etc.)

Originator and Lecturer, Touch of Class Pregame Seminar Series, UA College of Arts &

Sciences, Fall 2004-present

Organizer and Lecturer, Scientist-for-a-Day Competition, Paul W. Bryant High School,

Tuscaloosa, 2004-2007

Search Committee Chair, Cellular Signaling position, Dept. Biological Sciences, The

University of Alabama, 2005-06

Graduate Students Trained:

Completed Degrees and Honors:

Michael A. Shiffler, M.S., 2002

2000-01 University-wide recipient of Excellence in Teaching for a Masters Student

2001 Hill Fellowship, Department of Biological Sciences

currently a M.B.A./Ph.D. student at UA (with Dr. Ed Stephenson)

Elaina Sexton, M.S., 2002

currently a medical student, University of South Alabama

Christopher C. Gelwix, M.S., 2003

Graduate Council Fellowship Recipient 2002-03

currently a medical resident, Medical College of Virginia

Summer Slater, M.S. , 2005

currently a biology/chemistry teacher at a private academy in Lafayette, LA

Shelli N. Williams, M.S. 2004, Ph.D., 2006

2001 Isabella Hummel Graham Scholarship Recipient, University Women's Club

Graduate Council Research Fellowship Recipient, Summer 2000

Graduate Council Thesis Fellowship Recipient, Fall 2001-Summer 2001

Graduate Student Registration Award, American Society for Cell Biology, 2001

13th International C. elegans Meeting, Student Travel Award, 2001

Research and Travel Award, UA Graduate School, 2001

Research and Travel Award, UA Graduate School, 2002

Worthington Award Recipient, American Society for Cell Biology, 2002

14th International C. elegans Meeting, Top Poster Award Recipient, 2003

The Joab Langston Thomas Award, UA Biological Sciences, 2005

currently employed by Central Intelligence Agency, Washington, D.C.

Songsong Cao, M.S., 2005, Ph.D., 2006

Graduate Council Fellowship Recipient, 2000-01 and 2003-04

Competitive Graduate Student Travel Award, American Society for Cell Biology, 2001

Research and Travel Award, UA Graduate School, 2001

Research and Travel Award, UA Graduate School, 2002

The Joab Langston Thomas Award, UA Biological Sciences, 2004

The University of Alabama Excellence in Research by a Doctoral Student Award, 2005

Currently a postdoctoral fellow, Duke University

Current Graduate Students:

Shusei Hamamichi, Ph.D. Student, 2003-present

Jafa Armagost, Ph.D Student, 2005-present

Pan Chen, Ph.D. Student, 2006-present

Adam Harrington, Ph.D. Student, 2006-present

Michelle Tucci, M.S. student, 2006-present

Bwarenaba Kautu, M.S. student, 2006-present

Alexander Burdette, Ph.D. student, 2007-present

Undergraduates Supervised in Research and Notable Honors:

John Paul Bevel, 2000-2001

Author on manuscript in peer-reviewed journal

currently a research technician

Clay Blanton, 2000

currently in information technology

Shelli Williams, 2000

Author on 3 manuscripts in peer reviewed journals and textbook author

Jenny Whitworth, 2000-2002

Howard Hughes Medical Institute Research Intern, 2000-2002

currently a medical doctor

Sarah Howard, 2001

currently in information technology

Daniel Wyatt, 2001-2002

currently in pharmacy school

Meiklejohn McKenzie, 2001

currently a medical doctor

Sarah B. Adair, 2001-2003

USA Today All-USA Academic Team, 1st Team 2003 (top 20 nationally)

USA Today All-USA Academic Team, 3rd Team 2003 (top 60 nationally)

Goldwater Scholar, 2002

Pi Kappa Phi, Undergraduate Research Award, 2002

Howard Hughes Medical Institute Research Intern, 2001-03

McWane Undergraduate Research Award, 2002

Randall Outstanding Undergraduate Research Award, 2003

Outstanding Senior Award, 2003

currently a medical student at UAB

Andrea Braden, 2002-2003

Randall Outstanding Undergraduate Research Award, 2003

Pi Kappa Phi, Undergraduate Research Award, 2003

Howard Hughes Medical Institute Research Intern, 2002-03

currently a medical resident, University of Connecticut

Author on manuscript in peer reviewed journal

Cody Locke, 2002-2006

USA Today All-USA Academic Team, 1st Team 2006 (top 20 nationally)

USA Today All-USA Academic Team, 2nd Team 2004 and 2005 (top 40 nationally)

Benjamin-Cummings Biology Award Recipient, 2003 (1 of only 4 nationally)

Randall Outstanding Undergraduate Research Award, 2004 and 2005

Merit Award Recipient, National Society for Collegiate Scholars, 2004 (1 of 50 nationally)

Outstanding Sophomore, UA College of Arts & Sciences, 2003-2004

Howard Hughes Medical Institute Research Intern, 2004-present

Goldwater Scholarship Recipient, 2005

UA Alumni Association Outstanding Senior, male, 2006

1st Place, University of Alabama System-Wide Honors Research Competition, 2006

Author on 3 manuscripts in peer reviewed journals

Currently research technician, Caldwell lab

Matthew Cybulsky, 2003

Howard Hughes Medical Institute Research Intern, 2001-2003

currently pursuing a M.S. in Hospital Administration (following receipt of an M.S.

in Bioethics at Case Western Reserve University)

Amy Shirley, 2003-2004

Randall Outstanding Undergraduate Research Award, 2004

Howard Hughes Medical Institute Research Intern, 2003-2004

currently a Ph.D. student at UA (Sloan lab)

Kimberly Peters, 2003-2005

Outstanding Sophomore of the College of Arts & Sciences, 2002-03

Howard Hughes Medical Institute Research Intern, 2003-2005

McWane Undergraduate Research and Travel Award. 2004

1st Prize, University of Alabama Undergraduate Research Competition, 2004

currently Ph.D. student at UNC Chapel Hill

Shermeen Memon, 2004-2006

Outstanding Sophomore, The University of Alabama, 2003-04

1st Prize, Univ. of Alabama Undergraduate Research Competition, 2004 and 2006

Randall Outstanding Undergraduate Research Award, 2005 and 2006

Howard Hughes Medical Institute Research Intern, 2005-present

UA Alumni Association Outstanding Senior, female, 2006

1st Place, University of Alabama System-Wide Honors Research Competition, 2006

Author on manuscript in peer-reviewed journal

currently medical student at UAB

Amber Clark, 2004-2006

Howard Hughes Medical Institute Research Intern, 2004-present

3rd Prize, University of Alabama Undergraduate Research Competition, 2005

Randall Outstanding Undergraduate Research Award, 2006

Author on manuscript in peer-reviewed journal

Currently research technician, Caldwell lab

Perry Guevara, 2004

Stephanie Brennan, 2004

John Philips, 2004-2006

Truman Scholarship Recipient, 2005

Howard Hughes Medical Institute Research Intern, 2005-present

currently medical student at Vanderbilt

Renee Rivas, 2004-present

NSF REU grant recipient

Howard Hughes Medical Institute Research Intern, 2006-present

3rd Place, University of Alabama System-Wide Honors Research Competition, 2006

Goldwater Scholarship Recipient, 2006

McWane Undergraduate Research Award, 2006

Benjamin-Cummings Biology Award Recipient, 2006 (1 of only 4 nationally)

Meaghan Till, 2005-2006

2006 Isabella Hummel Graham Scholarship Recipient, University Women's Club

Howard Hughes Medical Institute Research Intern, 2006

Robyn Thomas, 2005-2007

Howard Hughes Medical Institute Research Intern, 2005-present

2nd Place, University of Alabama System-Wide Honors Research Competition, 2006

Amgen Fellow, Teach for America (1 of 50 from 20,000 applicants nationwide)

Ashley Phares, 2005-present

Stacey Fox, 2005-present

Jeana Blalock, 2005-2007

Howard Hughes Medical Institute Research Intern, 2006-present

Adam Knight, 2005-present

David Agee, 2006

Howard Hughes Medical Institute Research Intern, 2006

Kyle Lee, 2006-present

Susan DeLeon, 2006-present

John Ricketts, 2006-present

Max Thompson, 2006-present

Lauren Bryant, 2006-present

Alicia Wright, 2006-2007

Kalen Berry, 2006-present

Presentations:

Meetings

American Society for Cell Biology, International Meeting, San Francisco, December

8-14, 2000. 1 presentation

13th International C. elegans Meeting, Los Angeles, June 22-26, 2001

4 separate presentations given

American Society for Cell Biology, International Meeting, Washington, D.C.

December 8-14, 2001. 2 presentations given

4th Annual Conference of the Southern Association for the History of Medicine and

Science, The Ochsner Clinic Foundation, New Orleans, LA Feb. 22-23, 2002

invited keynote speaker

5th Annual Graduate Student Research Conference, The University of Alabama,

March 13-14, 2002 2 presentations given

4th International Dystonia Symposium, Emory University, Atlanta, June 13-15, 2002

invited platform speaker

Midwest C. elegans Meeting, St. Louis, June 28-30, 2002. 2 presentations

American Society for Cell Biology 42nd Annual Meeting, San Francisco, Dec. 14-18,

2002, 4 presentations given

17th National Conference on Undergraduate Research, March 13-15, 2003, Salt Lake

City, UT. 1 presentation

Ubiquitin & Ubiquitin-like Modifications in Health & Disease Meeting, NIH,

Bethesda, MD, March 23-24, 2003, 1 presentation

Alabama Dieticians Association Annual Meeting, Montgomery, AL, March 20, 2003,

invited lecturer

14th International C. elegans Meeting, Los Angeles, CA, June 8-July 3, 2003,

4 presentations

Northwest Regional Dystonia Symposium, Tacoma, WA, July 27-28, 2003,

invited lecturer

Cell Biology of the Neuron, 2003 Society for Neuroscience Meeting, New Orleans, LA,

Nov. 7, 2003, 2 presentations

Bachmann-Strauss Dystonia & Parkinson Foundation 2003 Think Tank,

New York, NY, Nov. 13-15, 2003, invited lecturer

Dystonia Medical Research Foundation 2004 Grantholders Workshop,

Atlanta, GA, Feb. 19-20, 2004, invited platform lecturer

6th Annual Graduate Student Research Conference, The University of Alabama

March 11, 2004, keynote speaker

2nd Canadian Developmental Biology Symposium, Banff, Canada, Apr. 4, 2004

1 presentation

8th International Congress of Parkinson's Disease & Movement Disorders,

Rome, Italy, June 13-17, 2004, 2 presentations

10th Annual Spasmodic Torticollis Dystonia International Patients Meeting

Orlando, FL Oct. 1-2, 2004, invited platform lecturer

Society for Neuroscience Annual Meeting, San Diego, CA,

2 presentations

28th Annual Meeting of The American Epilepsy Society, New Orleans, LA, Dec. 3-8,

2004, invited presentation

American Society for Cell Biology, 44th International Meeting, Washington, D.C.

December 4-9, 2004. 2 presentations

15th International C. elegans Meeting, Los Angeles, CA, June 25-29, 2005

7 presentations

29th Annual Meeting of The American Epilepsy Society, Dec. 4-8, 2004, invited

invited platform lecturer

American Society for Cell Biology, 45th International Meeting, San Francisco, CA

December 10-14, 2005. 3 presentations

Genetics Society of America, Model Organisms to Human Biology, San Diego, CA

January 5-7, 2006

2006 Biotechnology Association of Alabama Annual Meeting, Birmingham, AL

February 3, 2006, invited lecturer

Cambridge Healthscience Institute, Protein Folding Disorders Meeting,

Baltimore, MD, March 9-10, 2006, invited platform lecturer

Bachmann-Strauss Dystonia and Parkinson Foundation Think Tank,

United Nations Plaza, November 15-16, New York, NY, invited lecturer

American Society for Cell Biology, 45th International Meeting, San Diego, CA

December 9-13, 2006. 5 presentations

NIH/Dystonia Medical Research Foundation Workshop, Animal Models of

Dystonia, January 11-12, Washington, D.C., invited lecturer/session leader

Invited Seminars (in addition to those at meetings):
Pasteur Society, The University of Alabama, Oct. 19, 1999

Washington & Lee University, Lexington, VA, Biology Department, Dec. 4, 1999

The University of Alabama at Huntsville, Biology Department, Dec. 8, 1999

Mississippi State University, Starkville, MS. Department of Biochemistry and

Molecular Biology, Dec. 6, 2000

Alabama Science-In-Motion, high schoolteacher enhancement program, Feb. 20, 2001.

WalkAmerica Walk-a-thon fundraiser, Birmingham, AL

The March of Dimes Birth Defects Foundation, Feb. 27, 2001, keynote speaker

WalkAmerica Walk-a-thon Kickoff Fundraiser, Tuscaloosa, The March of Dimes

Birth Defects Foundation, Mar. 13, 2001, keynote speaker

Tri-Beta, National Biological Honor Society, UA chapter, Apr. 12, 2001

Alpha Epsilon Delta, Premedical Honorary, UA chapter, Oct. 30, 2001

University of Maryland Biotechnology Institute, Dec. 6, 2001

Weis Center for Research, The Geisinger Clinic, Danville, PA, Mar. 22, 2002

Rhodes College, Memphis, Department of Biology, Apr. 12, 2002

Tuscaloosa Dietetic Association, Apr. 23, 2002

University of Alabama at Birmingham Medical School, Department of Cell Biology,

Apr. 24, 2002

UA School of Library and Information Studies, Medical Informatics Program,

Apr. 30, 2002

Blount Program Convocation, The University of Alabama, February 2003

Parker-Adams Seminar Series, The University of Alabama, March 2003

UA Leadership Board, Spring Meeting 2003

Southern Research Institute, Birmingham, AL April 25, 2003

Alabama Parkinson's Disease Association, Birmingham, AL, Aug. 17, 2003

University of Alabama Huntsville, Hudson Biotechnology Lecture Series, Oct. 19, 2003

Shelton State Community College, Tuscaloosa Phi Theta Kappa Leadership Series,

Oct. 29, 2003

Tulane University, Dept. Cell & Molecular Biology, New Orleans, LA, Oct. 31, 2003

Stanford University, Department of Genetics Palo Alto, CA, Dec. 15, 2003

The Parkinson's Institute, Sunnyvale, CA, Dec. 15, 2003

University of Idaho, Moscow, ID, Dept. Biological Sciences, Apr. 9, 2004

University of Alabama at Birmingham Medical School, Grand Rounds in Neurology,

May 25, 2004

Mississippi State University, Starkville, MS, Dept. Biological Sciences, Aug. 20, 2004

The University of Alabama, Tuscaloosa, Dept. Biological Sciences, Sept. 2, 2004

Parkinson's Association of Alabama, Birmingham, AL, Oct. 17, 2004

The Michael J. Fox Foundation, Las Vegas, NV, Jan. 19, 2005

Gene Therapy Center at UAB, Feb. 1, 2005

Rogers Science & Engineering, Library, seminar for UA community, Feb. 9, 2005

Washington & Lee University, Lexington, VA, University Lecturer, Feb. 28, 2005

Washington & Lee University, Lexington, VA, Biology Dept. seminar, March 1, 2005

New Mexico State University, Las Cruces, NM, Dept. Biological Sciences,

April 21, 2005

Dystonia Medical Research Foundation Patient Symposium, Los Angeles, CA,

May 18, 2005

South Alabama Dystonia Support Group, Mobile, AL, June 5, 2005

The Mayo Clinic, Jacksonville, FL, Alzheimer's and Parkinson's Lecture Series,

August 12, 2005

Seton Hall University, West Orange, NJ, Sept. 21, 2005

Reynolds Lecture, University of Alabama at Birmingham, Reynolds Historical

Library, Oct. 19, 2005

University of Alabama System-Wide Honors Research Day, keynote lecturer,

April 14, 2006

Dystonia Medical Research Foundation Patient Symposium, Chicago, May 17, 2006

University of Tennessee, Knoxville, TN, Biochemistry, Cell & Molecular Biology

Departmental Retreat, keynote lecturer, August 21, 2006

Parkinson's Association of Alabama, 2006 Annual Meeting, Birmingham, AL,

Sept. 13, 2006

Paul W. Bryant High School, Tuscaloosa, AL, Oct. 5, 2006

University of Alabama at Birmingham, Dept. Biochemistry & Molecular Biology

and Dept. of Neurobiology Joint Seminar, Nov. 20, 2006

University of West Alabama, Biology Department Seminar, Dec. 1, 2006

University of Alabama, Gorgas Library Public Lecture Series, Feb. 22, 2007

University of Tennessee-Oak Ridge National Laboratory Genome Science and

Technology Program, March 9, 2007

Pennington Biomedical Research Center, Baton Rouge, LA, March 16, 2007

City University of New York (CUNY), College of Staten Island,

Center for Developmental Neuroscience and Developmental Disabilities,

New York, NY, May 21, 2007

Media Relations:

Newspaper and Magazine Articles

Dialog, cover story on my teaching, February 7, 2000

UA Press Release on my teaching, February 23, 2000

The Birmingham News, story on my teaching, February 28, 2000

The Crimson White, story on my teaching, April 6, 2000

The Tallassee Tribune, story on my research, June 8, 2000

The Tuscaloosa News, full-page feature story on my research, June 16, 2000

The Crimson White, story on my research, June 28, 2000

The Progress (a New Jersey paper), story on my research, July 2000

The Birmingham News, story on my research, August 21, 2000

Library Horizons: A Newsletter of UA Libraries, story on electronic databases, Fall 2000

UA Press Release on grant award from March of Dimes, Feb. 23, 2001

Dateline Alabama, feature story on my research, March 6, 2001

The Crimson White, story on my research, March 8, 2001

The Anniston Star, feature story on my research. March 18, 2001

The Tuscaloosa News, cover story on my research and a profile of my graduate student,

Mike Shiffler, March 29, 2001

The Huntsville Times, Health Notes, story on my research, March 30, 2001

The Birmingham Post-Herald, feature profile on my career, April 2, 2001

Alabama Alumni magazine, story on my research, April/May 2001

The Decatur Daily, story on my research and student, Sarah Adair, July 11, 2001

The Tuscaloosa News, consulted for front-page story on, stem cells, Aug. 10, 2001

UA Press Release on my teaching, Nov. 14, 2001

The University of Alabama Research Magazine, feature story on my research, 2002

The Tuscaloosa News, story on my research and career profile of my wife and myself

February 10, 2002

UA Press Release on my research with undergraduate Sarah Adair, Feb. 27, 2002

USA Today, story on my student Sarah Adair, a 3rd Team selection to the USA Today

All-USA College Academic Team, for her research in my lab, February 27, 2002

The Progress (a New Jersey paper), career profile and story on my research, April 11, 2002

Howard Hughes Medical Institute Website, cover story on my teaching, April 2002

Collegian, UA Arts & Sciences, story on my research student Sar, ah Adair, September 2002

Dystonia Dialogue (Chicago),, , , newsletter for dystonia medical research and patient

community, biography, career profile, and feature story on my research, Oct. 2002

Michael J. Fox Foundation for Parkinson's Research, international press release on my

receipt of one of only 11 grants awarded internationally for Parkinson's Research,

Jan. 13, 2003

UA Press Release, story on my receipt of one of only 11 grants awarded internationally

from the Michael J. Fox Foundation for Parkinson's Research, Jan. 17, 2003 (see

listing of many resulting news stories nationally)

The Tuscaloosa News, story on Michael J. Fox grant, Jan. 20, 2003

UA Press Release, story on our publication of the cellular function of a gene related to a

human movement disorder termed dystonia, Jan. 29, 2003

Howard Hughes Medical Institute, international press release, on our discovery

pertaining to the cellular cause of dystonia, February 1, 2003

Dystonia Medical Research Foundation, cover story of their webpage: www.dystoniafoundation.

org, on our discovery pertaining to the cellular cause of dystonia,

February 1, 2003

Dialog, story on Michael J. Fox grant, Feb. 3, 2003

UA Press Release, story on my Ph.D. student Shelli Williams for receipt of the

prestigious Worthington Award for her research, Feb. 5, 2003

Dateline Alabama, story on Michael J. Fox grant, Feb. 9, 2003

USA Today, cover story on my student Sarah Adair, a 1st Team selection to the USA Today

All-USA College Academic Team, for her research in my lab, Feb. 13, 2003

Dateline Alabama, story on my Ph.D. student Shelli Williams, February 20, 2003

Baldwin Register, story on my Ph.D. student Shelli Williams for Worthington Award,

Feb. 19, 2003

The Tuscaloosa News, story about a workshop on the Human Genome Project that my

I organized for the local minority community, Feb. 23, 2003.

Alabama Alumni Magazine, story on Michael J. Fox grant, March 2003

DatelineAlabama, story on undergraduate science journal, JOSHUA, that I initiated as

faculty advisor of Tri-Beta, March 14, 2003

National Institutes of Neurological Disease and Stroke, cover story:

www.ninds.nih.gov, on our discovery pertaining to the cellular cause of dystonia,

March 28, 2003

The Crimson White, story on undergraduate science journal, JOSHUA, March 31, 2003

Alabama Alumni Magazine, story on undergraduate science journal, JOSHUA, March 2003

• The following websites also posted feature stories on our discovery pertaining to the

cellular cause of dystonia in between February-March 2003:

o www.wiat.com, WIAT TV-42, Medical Minute

o www.eurekalert.org, EurekAlert biomedical news site

o www.ParkinsonsChat.com. Parkinson's Disease Treatment & Information site

o www.al.com, Alabama news site

o www.northernlight.com, medical news site

o www.sciencedaily.com, science news site

o www.scienceblog.com, science news site

o www.cnsfoundation.org, children's neurobiological solutions foundation site

o www.ms-network.org, multiple sclerosis site, Global Medical News story section

o www.hdlighthouse.org, Huntington's disease research and patient site

o www.wpda.org, World Parkinson Disease Association site

o www.aidschat.com, AIDS and biomedical research site

o www.wemove.org, movement disorders newsletter

Dialog, cover story featuring my wife and myself on our discovery pertaining to the

cellular cause of dystonia, March 31, 2003

Biophotonics International, "Prospects in Medicine: GFP sheds light on protein

folding", feature story on our discovery pertaining to the cellular cause of

dystonia, April 2003 issue

The Scientist, international science news magazine, "Researchers Reveal a New Twist in

Torsion Dystonia", feature story on our discovery pertaining to the cellular cause

of dystonia, April 21, 2003 issue and www.the-scientist.com

Howard Hughes Medical Institute Bulletin, "Brain Drain", feature story on our

discovery pertaining to the cellular cause of dystonia, June 2003 issue.

The Parkinson's Institute, press release on Michael J. Fox grant, June 2, 2003

Alabama Alumni Magazine, cover story on my student Sarah Adair, "The Best and The

Brightest Times 5", on her selection to the USA Today All-USA College

Academic 1st Team, for her research in my lab, June 2003

UA Press Release, story related to my receipt of a National Science Foundation

CAREER Award, July 11, 2003

The Tuscaloosa News, cover story, West Alabama section, related to NSF CAREER

Award and research into human epilepsy, July 24, 2003

The Times Daily, story related to NSF CAREER Award/epilepsy, July 24, 2003

Sarasota Herald-Tribune (FL), story related to NSF CAREER Award/epilepsy, July 24, 2003

The Birmingham News, story related to NSF CAREER Award/epilepsy, July 24, 2003

Gadsden Times, story related to NSF CAREER Award/epilepsy, July 25, 2003

NBC13.com, Healthbeat13, story related to NSF CAREER Award/epilepsy, July 25, 2003

Washington & Lee Alumni Magazine, feature story about our research, Summer 2003

UA Press Release, story on my freshman research student Cody Locke, who was selected as

the recipient of the 2003 Benjamin-Cummings Biology Prize (1 of 4 nationally) for his

work in my laboratory into epilepsy genetics, Aug. 6, 2003

Dystonia Medical Research Foundation 2002 Annual Report, "Foundation-Funded

Investigator Discovers Function of TorsinA", featured story on our research, Aug. 2003

Crimson Tide Kickoff Football Game Program, feature story on Cody Locke Sept. 20, 2003

Strategies: Benjamin Cummings Newsletter, feature story on Cody Locke Sept. 20, 2003

American Society for Cell Biology 2003 Press Book, international press release and media

guide (1 of 13 abstracts selected from meeting of ~10,000 attendees)

Science magazine, feature online research news article, on a separate Caldwell Lab

report at the 2003 American Society for Cell Biology international meeting.

Biophotonics International, "Fluorescence Provides Insight into Seizure Mechanisms",

news story on our discovery pertaining to the cellular cause of epilepsy, Jan. 2004

USA Today, cover story on my student Cody Locke, a 2nd Team selection to the USA

Today All-USA College Academic Team, for his research in my lab, Feb. 11, 2004

UA Press Release, story on my undergraduate research student Cody Locke and USA

Today selection, Feb. 12, 2004

The Crimson White, story on my graduate students receiving the prestigious Worthington

Award from the American Society for Cell Biology 2 years in a row, Feb. 20, 2004.

Dialog, story on my undergraduate research student Cody Locke and his USA

Today selection for his research into epilepsy, Feb. 23, 2004

E-MOVE Movement Disorders Newsletter, international press release announcing our work

as one of 2 selected highlights from the 3000 person 8th International Movement

Disorders Congress (Rome, Italy); July 9, 2004.

US News & World Report, full-page advertisement citing my student Cody Locke as 1 of 4

USA Today All-USA Academic Team selections. August 30, 2004

Howard Hughes Medical Institute, international press release announcing our development

of a C. elegans model for human epilepsy; Sept. 1, 2004

The Scientist, research story on our development of a model for human epilepsy Sept. 2004

A Touch of Class, UA College of Arts & Sciences, Pre-football game lecturer, Sept. 2, 2004

The Tuscaloosa News, feature story on our research into epilepsy, Oct. 4, 2004

UAB Reporter, story on our research into epilepsy, Oct. 4, 2004

DystoniaST, news magazine, feature story on our research, cover photo, Jan. 2005

Dialog, photo and story about high-school outreach program I founded, Scientist-for-a-Day

USA Today, 2005 All-USA Academic Team, story on my student Cody Locke and his

research in our lab, Cody was named to this team for the 2nd year in a row, Feb. 17. 2005

Science magazine, NetWatch, feature story on epilepsy database generated in our lab,

Feb. 7, 2005 issue

Dialog, story on Cody Locke being named to USA Today All-Academic Team, Feb. 7. 2005

The Bulletin of the Howard Hughes Medical Institute, Winter 2005 issue, feature story on my

research and mentorship with undergraduates

Inside Higher Ed, newsletter with feature story "Young Biologist Seizes the Moment" on my

research with Cody Locke, March 3, 2005

UA Press Release, "UA Scientists Demonstrate Protein's Therapeutic Potential for

Parkinson's" April 12, 2005

The Tuscaloosa News, cover story, "UA Team Takes Step in Finding Treatment", on my

research into Parkinson's disease, April 14, 2005

The Associated Press, national press release "UA Team Advances Parkinson's Treatment",

on my research into Parkinson's disease, April 14, 2005

Atlanta Journal Constitution, story on my research into Parkinson's disease, April 14, 2005

Columbus Ledger-Inquirer, story on my research into Parkinson's disease, April 14, 2005

AL.com, story on my research into Parkinson's disease, April 14, 2005

Dateline Alabama, story on my research into Parkinson's disease, April 14, 2005

Gadsen Times, story on my research into Parkinson's disease, April 14, 2005

Times Daily, story on my research into Parkinson's disease, April 14, 2005

Anniston Star, story on my research into Parkinson's disease, April 15, 2005

Biloxi Sun Herald, story on my research into Parkinson's disease, April 16, 2005

National Institute of Neurological Disorders and Stroke, national press release on my

research into Parkinson's Disease, cover of NINDS webpage, June 3, 2005

News-Medical.Net, story on my research into Parkinson's disease, June 4, 2005

Collegian, UA Arts & Sciences, story on my receipt of Leadership Board Fellowship,

October 2005

The Bachmann-Strauss Dystonia and Parkinson Foundation Outlook Newsletter, cover story

on our dystonia and Parkinson's research, Fall 2005

• CASE Press Release on U.S. Professors of the Year, www.case.org, November 17, 2005

The Birmingham News, feature article on my being named Professor of the Year for the State

of Alabama from the Carnegie Foundation and CASE, Nov. 17, 2005

UA Media Relations Web Site Package about my being named Professor of the Year,

www.ua.edu/academic/professorofyear

Crimson White, feature story on my wife and myself, as a research team, January 2006

USA Today, feature story on Cody Locke, Caldwell Lab undergraduate researcher, named to

USA Today All-USA Academic 1st Team, February 2006

Howard Hughes Medical Institute Bulletin, Winter 2006 Bulletin, brief story about being

named Professor of the Year

eTORCH, Univ. of Tennessee Alumni Newsletter, feature story about being named

Professor of the Year, March 2006

Alabama Alumni Magazine, feature story on being an inventor on several patents,

Spring 2006

Dialog, UA Faculty/Staff newsletter, feature story on my student, Renee Rivas, 2006

Goldwater Scholarship recipient

BAMA BOUND, featured participant on recruiting DVD, May 2006

The Tuscaloosa News, feature story on new Parkinson's drug screening pipeline with our lab

and The Parkinson's Institute, May 6, 2006

The PI Newsletter, The Parkinson's Institute, Sunnyvale, CA, Spring 2006

Dialog, UA Faculty/Staff newsletter, story on new Parkinson's drug screening pipeline with

our lab and The Parkinson's Institute, June 12, 2006

Press Release, Howard Hughes Medical Institute, story on new discovery in Science

magazine on Parkinson's Disease, June 22, 2006

The New York Times, story on our new discovery in Science magazine on Parkinson's

Disease, June 22, 2006

Forbes, story on new discovery in Science magazine on Parkinson's Disease, June 22, 2006

New Scientist, story on our new discovery in Science magazine on Parkinson's Disease,

June 22, 2006

Nature, story on new discovery in Science magazine on Parkinson's Disease, June 22, 2006

Howard Hughes Medical Institute Bulletin, August 2006 issue, feature story about

JOSHUA and undergraduate science journals

Howard Hughes Medical Institute Bulletin, November 2006 issue, feature story about

our discovery in Science magazine on Parkinson's Disease

Television Appearances and Press Conferences:

WIAT-TV, CBS 42, Birmingham, CBS affiliate, 10 PM News

Feature story on my research, June 5, 2000

WJRD, Tuscaloosa, 10 PM News

Feature story on my research, June 22, 2000

WVUA Cable TV 34, Tuscaloosa

Feature story on my research, July 2000

Great Day Tuscaloosa!

Invited guest on television talk show to discuss my research, January 26, 2001

ABC33/40, Birmingham, ABC affiliate, 5 PM, 6 PM, and 10 PM News

Feature story on my research and the Human Genome Project, February 12, 2001

Press Conference, Alabama State House, Montgomery

ABC/CBS/NBC/FOX-TV and National Satellite link

March of Dimes Birth Defects Foundation National Press Conference, February 28, 2001

Research! America 2002 Science/Media Forum, invited panelist for Washington, D.C.-

based biomedical lobby-sponsored program. Hosted by Jim Hartz (NBC Today Show).

Participants included all 4 major networks and National Public Radio, April 22, 2002

Great Day Tuscaloosa!

Invited guest on television talk show to discuss my research into Parkinson's

Disease, June 2, 2001

FOX 6, Birmingham Fox TV affiliate, 5 and 9PM news, full-feature story

"Against All Odds" on my research by news anchor Andrea Lindenberg,

November 26, 2002

ABC 33/40TV Birmingham, ABC affiliate, 5 PM and 10 PM News

Feature story on major medical discovery involving our research, Jan. 29, 2003

WIAT CBS42 Birmingham, CBS affiliate, 5 PM, 6 PM, and 10 PM News

Feature story on major medical discovery involving my research, Jan. 30, 2003

WUVA7 Tuscaloosa, 5 PM News

Feature story on major medical discovery involving my research, Jan. 31, 2003

WAKA-CBS, Montgomery-Selma, CBS affiliate, Feature story on major medical

discovery involving my research, 10:00PM News, Feb. 3, 2003

Great Day Tuscaloosa!

Invited guest on television talk show to discuss my research into epilepsy; Aug. 4, 2003

Press Conference, American Society for Cell Biology, 43rd International Meeting,

San Francisco, CA, Dec. 14, 2003. Feature story for media release on our research

FOX6, Birmingham Fox TV affiliate, 6 PM News, feature story on our research, Oct. 22,

2004

WUVA7 Tuscaloosa, 5 PM News

Feature story on high school science outreach program that I started with Paul

W. Bryant High School

NBC13, Birmingham, NBC affiliate, story on my research into Parkinson's

disease, April 14, 2005

FOX 6, Birmingham Fox TV affiliate, 5 PM news, full-feature story on my

research into Parkinson's disease, April 15, 2005

• Several feature stories on my Alabama Professor of the Year award all appeared

in the television media: NBC, ABC, FOX, CBS affiliates, as well as on WVUA.

November 17, 2005

The Mike Shula Show, feature story about my Alabama Professor of the Year

Award. WUVA, November 21, 2005.

CBS TV, WIAT, Birmingham, 10PM newscast story on new Parkinson's drug

screening pipeline with our lab and The Parkinson's Institute, May 7, 2006

NBC13, Birmingham, NBC affiliate, story on my research into Parkinson's

disease, June 22, 2006

University of Alabama National Television Commercial, "Crimson is….",

shown nationally on ESPN, CBS, and all local network affiliates