Brenner's Recent Publications


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SELECTED PUBLICATIONS

Brenner, M., Johnson, A.B., Boespflug-Tanguy, O., Rodriguez, D., Goldman, J.E. and Messing, A. (2001). Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nature Genetics 27: 117-120.

Li, R., Messing, A., Goldman, J.E. and Brenner, M. (2002). GFAP Mutations in Alexander Disease. Int. J. Dev. Neurosci. 20:259-268.

Su, M., Hu, H., Lee, Y., d'Azzo, A., Messing, A. and Brenner, M. (2004). Expression specificity of GFAP transgenes. Neurochem. Res. 29:2075-2093.

Li, R., Johnson, A.B., Salomons, G.S., Goldman, J.E., Naidu, S., Quinlan, R., Cree, B., Ruyle, S.Z., Banwell, B., D''Hooghe, M., Siebert, J.R., Rolf, C.M., Cox, H., Reddy, A., Gutiérrez-Solana, L.G., Collins, A., Weller, R.O., Jakobs, C., Messing, A., Van der Knaap, M.S., and Brenner, M. (2005). GFAP mutations in infantile, juvenile and adult forms of Alexander disease. Annals Neurol. 57(3):310-326.

Van der Knaap, M.S., Salomons, G.S., Li, R., Franzoni, E., Gutiérrez-Solana, L.G., Smit, L.M.E., Robinson, R., Ferrie, C.D., Cree, B., Reddy, A., Thomas, N., Banwell, B., Barkhof, F., Jakobs, C., Johnson, A., Messing, A. and Brenner, M. (2005). Unusual variants of Alexander disease. Annals Neurol. 57(3):327-338.

Li, R., Salomons, G.S., Johnson, A., Van der Knaap, Boespflug-Tanguy, O., Rodriguez, D., Gorospe, J.R., Messing, A. and Brenner, M. (2006). Propensity for paternal inheritance of de novo mutations in Alexander disease. Hum. Genet. 119:137-44.

de Leeuw, B., Su, M., ter Horst, M., Iwata, S., Rodijk, M., Hoeben, R.C., Messing, A., Smitt, P.S. and Brenner, M. (2006). Increased glia-specific transgene expression with GFAP promoters containing multiple enhancer elements. J. Neurosci. Res. 83:744-753.

Lee, Y., Su, M., Messing, A. and Brenner, M. (2006). Astrocyte heterogeneity revealed by expression of a GFAP-lacZ transgene. Glia 53:677-687.

Der Perng, M.D., Su, M., Wen, S.F., Li, R., Gibbon, T., Prescott, A.R., Brenner, M. and Quinlan, R.A. (2006). The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. Am. J. Hum. Genet. 79:197-213.

Howard, K.L., Hall, D.A., Moon, M., Agarwal, P., Newman, E., and Brenner, M. (2008) Adult-Onset Alexander Disease with Progressive Ataxia and Palatal Tremor. Mov. Disord. 23:118-122.

Lee, Y., Su, M., Messing, A., Su, M. and Brenner, M. (2008) GFAP promoter elements required for region-specific and astrocyte-specific expression. Glia 56: 481-493.

Liu, B., Wang, S., Brenner, M., Paton, J.F., and Kasparov, S. (2008) Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain. J Gene Med. 10:583-592.

Brenner, M., Goldman, J.E., Quinlan, R.A. and Messing, A. (2009). Alexander disease: a genetic disorder of astrocytes. In Parpura, V. and Haydon, P., Astrocytes in (patho)physiology of the nervous system, Springer, pp. 591-648.

Meisingset, T.W., Risa, Ø., Brenner, M., Messing, A. and Sonnewald, U. (2010).  Alteration of glial-neuronal metabolic interactions in a mouse model of Alexander disease. Glia, 58:1228–1234.

Cho, W., Brenner, M., Peters, N. and Messing, A. (2010).  Drug Screening to Identify Suppressors of GFAP Expression. Hum Mol Gen. 19:3169-3178.

Prust, M.J., Wang, J., Morizono, H., Messing, A., Brenner, M., Gordon, E.S., Hartka, T., Sokohl, A., Schiffmann, R., Gordish-Dressman, H., Albin, R., Amartino, H., Brockman, K., Dinopoulos, A., Dotti, M.T., Fain, D., Fernandez, R., Ferreira, J., Fleming, J., Gill, D., Griebel, M., Heilstedt, H., Kaplan, P., Lewis, D., Nakagawa, M., Pederson, R., Reddy, A., Sawaishi, Y., Schneider, M., Sherr, E., Takiyama, Y., Wakabayashi, K., Gorospe, R. and Vanderver, A. (2011).  GFAP mutations, age of onset and clinical subtypes in Alexander disease, Neurology 77:1287-1294.

Flint, D. and Brenner, M. (2011) Alexander disease, In Raymond, G.V., Eichler, F., Fatemi, A., and Naidu, S., Leukodystrophies), Mac Keith Press, London, pp. 106-129.

Messing, A., Li, R., Naidu, S., Taylor, P., Silverman, L., Flint, D., van der Knaap, M., and Brenner, M. Archetypal and new families with Alexander disease and novel mutations in GFAP. Arch. Neurol., in press.