West Lab Publications


  • Alves da Costa C, Sunyach C, Giaime E, West AB, Corti O, Brice A, Abou-Sleiman, P, Wood N, Takahashi H, Goldberg M, Shen J, Checler, F. “Transcriptional repression of p53 by parkin and impairment by autosomal recessive juvenile Parkinson’s disease-associated mutations” Nat Cell Biol. 2009 Oct 4. PMID: 19801972
  • Dawson TM, Moore DJ, West AB. “Revelations and revolutions in the understanding of Parkinson's disease.” Biochim Biophys Acta. 2009 Jul;1792(7):585-6
  • Weiss L.A. and the Autism Consortium (…, West AB.,…). “A Genome-wide linkage and Association Scan Reveals Novel Loci for Autism” Nature. 2009 Oct 8;461(7265):802-8. PMID: 19812673
  • Sen, S., Webber, P., West, AB. “Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity: Dependence on Dimerization” J Biol Chem 2009, Oct 13. PMID: 19826009
  • Webber, P., West, AB. “LRRK2 in Parkinson's disease: function in cells and neurodegeneration.” FEBS J. 2009 Oct 5. PMID: 19804415
  • Sen S, West AB. “The Therapeutic Potential of LRRK2 and Alpha-synuclein in Parkinson's Disease.” Antioxid Redox Signal. 2009 Mar 9
  • Aasly JO, Vilariño-Güell C, Dachsel JC, Webber PJ, West AB, Haugarvoll K, Johansen KK, Toft M, Nutt JG, Payami H, Kachergus JM, Lincoln SJ, Felic A, Wider C, Soto-Ortolaza AI, Cobb SA, White LR, Ross OA, Farrer MJ. “Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease.” Mov Disord. 2010 Jul 28
  • Lee BD, Shin JH, Vankampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. “Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.” Nat Med. 2010 Aug 22
  • Pungaliya PP, Bai Y, Lipinski K, Anand VS, Sen S, Brown EL, Bates B, Reinhart PH, West AB, Hirst WD, Braithwaite SP. “Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.” PLoS One. 2010 Oct 27;5(10):e13672.
  • Looyenga, B., Furge, K, Dykema, K, Koeman, J, West, AB., Teh, B, Resau, J., Giordano, T., MacKeigan, J. "Chromosomal Amplification of LRRK2 is Required for Oncogenic MET Signaling in Papillary Renal and Thyroid Carcinomas." Proc Natl Acad Sci U S A, 2011 Jan 25;108(4):1439-44
  • Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL. “Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.” Nat Med. 2011 May 22
  • Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB. “Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities.” J Mol Biol. 2011 Jul 22
  • Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. “LRRK2 Inhibition Attenuates Microglial Inflammatory Responses” J Neurosci. 2012 Feb 1;32(5):1602-11.
  • Stafa, K, Trancikova, A., Webber, PJ, Glauser, L., West, AB, Moore, DJ. “'GTPase Activity and Neuronal Toxicity of Parkinson's Disease-Associated LRRK2 is Regulated by ArfGAP1” PLoS Genet. 2012 Feb;8(2):e1002526. Epub 2012 Feb 9.
  • Trancikova A, Mamais A, Webber PJ, Stafa K, Tsika E, Glauser L, West AB, Bandopadhyay R, Moore DJ. “Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.” PLoS One. 2012;7(10):e47784