| Research Images and Videos |
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 Alzheimer's Immunofluorescent Micrograph (mag 63X)
This is an immunofluorescent micrograph of extracellular beta amyloid (red) plaque material among presumed astrocyte processes (green) containing deiminated protein in hippocampal sections of an Alzheimer's diseased brain. Autofluorescent lipofuscin is also seen as white, blue, purple or pink granular structures (Magnification: 63X).
 EAE Micrograph Showing Deiminated MBP Lesion (mag 10X)
Immunofluorescent micrograph demonstrating the relationship between myelin basic protein (red) and deiminated protein (green) in the cerebrum of a mouse with experimental autoimmune encephalomyelitis. This merged image demonstrates a lesion (yellow) containing what appears to be deiminated myelin basic protein (Magnification 10X). Copyright: Journal of Comparative Neurology 486:254-266, 2005.
 EAE Micrograph Showing Deiminated MBP Lesion (mag 20X)
Immunofluorescent micrograph demonstrating the relationship between myelin basic protein (red) and deiminated protein (green) in the cerebellum of a mouse with experimental autoimmune encephalomyelitis. This merged image demonstrates a lesion (yellow) containing what appears to be deiminated myelin basic protein (Magnification 20X). Copyright: Journal of Comparative Neurology 486:254-266, 2005
 EAE Micrograph Showing Lesion Area of Deiminated Glial Fibrillary Acidic Protein
Immunofluorescent micrograph demonstrating the relationship between glial fibrillary acidic protein (red) and deiminated protein (green) in the spinal cord of a mouse with experimental autoimmune encephalitis. This merged image demonstrates a large lesioned area containing what appears to be deiminated glial fibrillary acidic protein (yellow) (Magnification 40X). Copyright: Journal of Comparative Neurology 486:254-266, 2005.
 Immunohistochemical Staining of Deiminated Proteins
Immunohistochemical staining of deiminated proteins in a midline sagittal section of normal rat brain (magnification 0.5X). Copyright: Journal of Comparative Neurology 459:251-266, 2003.
 Confocal Immunofluorescent Micrograph of Human Cerebellum
Confocal immunofluorescent micrograph of normal human cerebellum showing the anatomical relationship between glial fibrillary acidic protein (red) and deiminated proteins (green). Co-localization (yellow) of these two markers is seen in numerous astrocytes (magnification 4X).
Research Videos
These are some interesting short videos showing the differences in normal mice vs. mice treated with MPTP and levodopa/carbidopa.
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