In UAB's Division of Neurosurgery, Corinne E. Griguer, PhD and her research team is searching for potential therapeutic targets in malignant glioma. A recent recipient of a Research Project Grant, her research interests include exploring the bioenergetic pathways involved in the development and progression of malignant glioma. Patient chemoresistance to temozolomide (TMZ), the frontline drug of choice to treat glioblastoma multiforme, limits treatment options. Griguer and her colleagues at the Southern Research Institute and University of Geneva have determined that increased cytochrome c oxidase (CcO) activity is associated with TMZ resistance in glioblastoma multiforme. In the future, analysis of CcO activity in gliomas may be used to predict overall survival and progression free survivals in patients with malignant glioma. CcO activity may serve as a target for small molecule inhibitiors that could be used to block acquisition of chemoresistance in glioma. Reversing TMZ insensitivity may lead to improved outcomes in patients with GBM.
The University of Alabama at Birmingham (UAB), Department of Neurosurgery provides adult and pediatric neurosurgical services to Alabama and the southeastern United States. Our faculty consists of more than 17 neurosurgeons, many whom are considered world experts in the treatment of brain tumors, neurovascular conditions, spinal disorders, functional disorders, and pediatric conditions. In 2016 we were ranked No. 25 nationally and No. 5 among public institutions by U.S. News & World Report. We are also committed to advancing the field of neurosurgery through cutting-edge research. Our faculty includes five dedicated scientists and many of our physicians are active in basic and clinical research. In order to continue growth and advancement, we are committed to training the next generation of neurosurgeons through our residency and fellowship programs. At UAB Neurosurgery, residents and fellows develop outstanding surgical skills, and are trained in evidence-based medicine and clinical outcomes research techniques.