Center Overview

The George M. O'Brien centers were established in 1987 as NIH-funded interdisciplinary research centers in kidney and urological diseases. The UAB-UCSD O'Brien Core Center for Acute Kidney Injury (AKI) is one of eight centers funded nation wide and is an interdisciplinary center of excellence in AKI-related research.  Centers are charged with providing shared resources to facilitate basic and clinical research on kidney disease and improve the effectiveness of translating research from basic to clinical practice. Centers also support pilot and Feasibility studies to develop and test innovative approaches to studying kidney disease.

The Center investigators benefit from access to a set of complementary Biomedical Research Core Resources that integrate existing intellectual and technological resources of UAB and UCSD providing defined services that facilitate the research of investigators pursuing AKI-related basic and clinical investigation.

Administrative Core - Director: Anupam Agarwal, MD

Biomedical Research Cores
Clinical Studies of AKI (Core A) -  Director: Ravindra Mehta, MD
Pre-Clinical Studies of AKI (Core B) - Director: Paul Sanders, MD
Bioanalytical Core (Core C) - Director: Stephen Barnes, PhD

Biostatistical Core - Director: Garry Cutter, PhD


The Educational component of the Center is used to:

  • increase collaborative interactions among Center members
  • enhance the expertise of investigators
  • foster the development of new projects with translational potential
  • facilitate training of the next generation of investigators in the field of kidney-related research


The Pilot and Feasibility studies provide funds for new, outstanding and innovative research proposals related to Acue Kidney Injury.  These funds provide investigators with one to two years of support along with access to the cores to support projects.