RPB/Rich Lecture - Irina Pikuleva, Ph.D.
05.15.2014 12:00 pm - 1:00 pm
DescriptionSeminar title: ‘Cholesterol metabolism in the retina and brain: different roles and therapeutic opportunities’
Speaker: Irina Pikuleva, PhD
Jules and Doris Stein Research to Prevent Blindness Professor
of Ophthalmology and Pharmacology
Department of Ophthalmology & Visual Sciences
Case Western Reserve University
Dr. Pikuleva studies cholesterol metabolism and cytochrome P450 enzymes (CYPs or P450s 27A1 and 46A1) whose role is to generate more polar forms of cholesterol for cellular elimination or regulation. The two major areas of research in Dr. Pikuleva’s laboratory are: 1) the link between cholesterol and diseases of the retina; and 2) effects of pharmacologic enhancement of cholesterol turnover in the brain. The ultimate goal of these studies is to identify new therapeutic targets and treatments for diseases of the eye (age-related macular degeneration and diabetic retinopathy) and the brain (Alzheimer’s disease).
A light lunch will be provided.