Research interests in Redox Biology are broad and encompass physiologic, pathophysiologic and therapeutic areas. Ongoing projects include understanding basic mechanisms of redox signaling involving reactive oxygen, nitrogen, sulfur, lipid and halogen species; delineating the effects of these species in inflammatory diseases including atherosclerosis, heart failure, acute lung injury, diabetes, infectious disease, cancer, neurodegeneration and transfusion medicine.  Selected projects include nitric oxide-based therapies for acute inflammation; reductive stress, proteotoxicity and heart failure; exercise and aging aspects of cardiac disease; role of nuclear-mitochondrial genome interactions in modulating redox signaling and chronic inflammation; heme-dependent toxicity in transfusion-associated end-organ injury; mitophagy, autophagy and  regulation of cell fate in Parkinson’s disease and heart failure; translational bioenergetics and role of mitochondrial redox capacity in disease diagnosis and treatment; role of metabolism and circadian rhythm on redox signaling in the liver and heart.

Related Faculty: Rakesh Patel, Shannon Bailey, Jianhua Zhang, John Chatham, Adam Wende

 

 

 

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