The Division of Pediatric Endocrinology and Diabetes offers an energetic research environment. Faculty and fellow research projects include the entire spectrum of pediatric endocrinology conditions, both basic science and clinically-oriented projects.
Research coordinator: Tammi Skelton RN, Section of Pediatric Endocrinology and Diabetes,
Particular areas of research include:
- Pathogenesis of Type 1 and Type 2 diabetes
- Optimizing current and long term health and well being in patients with diabetes
- The regulation of cortisol production by fat and liver tissue and its impact in obesity and diabetes. These investigations probe the crucial cortisol production enzyme 11 Beta hydroxysteroid dehydrogenase.
- Fast track continuous subcutaneous insulin infusion (CSII) in young children with newly diagnosed type 1 diabetes mellitus (T1DM)
- Implantable Antenna Sensors for Continuous Glucose Monitoring
- Autonomy Support Psychoeducation for Parents and Middle Adolescent with Type 1 Diabetes
- Diagnosing the Heterozygous State of Congenital Adrenal Hyperplasia Using Gas Chromatography/Mass Spectrometry Analysis of Random Urine Samples
- Effect of incretin therapies on weight and glycemic control in children and adolescents with Type 2 Diabetes Mellitus
- Effect of vitamin D on insulin secretion and sensitivity
- The regulation of FGF23 by growth hormone and the latter's effect on phosphate homeostasis
- The regulation of FGF 23 in endocrinological disorders
- Evaluation of etiology of difficult hypertriglyceridemia
- Lipid disorders in diabetes and obesity
- Relationship between idiopathic bone age advancement with adrenal androgen production
- The role of aromatase inhibitors in males with idiopathic bone age advancement
- Current clinical therapies in cystic fibrosis related diabetes
- Insulin sensitivity and the GH/IGF-1 axis in young children with cystic fibrosis
- Trial Net:
o We are an active participant in Trial Net (a study screening relatives of children with type 1 diabetes to determine if any family member is at risk for developing diabetes).
- Growth Hormone registries:
o The Endocrinology Division participates in post marketing surveillance and the national registries of multiple growth hormone products.
- Exenatide in Adolescents:
o Clinical trial examining the safety and efficacy of Exenatide in Adolescents with Type 2 Diabetes
Currently the Section has several active research projects approved by the University of Alabama Institutional Review Board. The Division avidly pursues publication of original scientific work well-respected peer-reviewed journals.
- The Comprehensive Diabetes Center (TCDC):
o A Comprehensive Diabetes Center was established in 2007. The Centers research interests include T- and B-cell immunology, pancreatic β cell biology and developmental biology. Centers research is directed at understanding the fundamental issues related to the development of type 1 diabetes. The goal the TCDC is to identify novel mechanisms or strategies to prevent or cure this disease.
- Endocrine Newborn Screening Center:
o The endocrine division collaborates with the Alabama State Screening program to optimize immediate and long-range follow up care of newborns with congenital hypothyroidism and adrenal hyperplasia. Longitudinal data analysis of clinical outcomes is a key component.