Research

The Division of Pediatric Endocrinology and Diabetes offers an energetic research environment.  Faculty and fellow research projects include the entire spectrum of pediatric endocrinology conditions, both basic science and clinically-oriented projects. 

Research coordinator:
Tammi Skelton RN
Section of Pediatric Endocrinology and Diabetes
Phone: 205-996-9569

Clinical/research programs:

  • The Comprehensive Diabetes Center (TCDC):A Comprehensive Diabetes Center was established in 2007. The Centers research interests include T- and B-cell immunology, pancreatic β cell biology and developmental biology. Centers research is directed at understanding the fundamental issues related to the development of type 1 diabetes. The goal the TCDC is to identify novel mechanisms or strategies to prevent or cure this disease.
  • Endocrine Newborn Screening Center:
    The endocrine division collaborates with the Alabama State Screening program to optimize immediate and long-range follow up care of newborns with congenital hypothyroidism and adrenal hyperplasia. Longitudinal data analysis of clinical outcomes is a key component.

Particular areas of research include:

  • Pathogenesis of Type 1 and Type 2 diabetes
  • Optimizing current and long term health and well being in patients with diabetes
  • The regulation of cortisol production by fat and liver tissue and its impact in obesity and diabetes. These investigations probe the crucial cortisol production enzyme 11 Beta hydroxysteroid dehydrogenase.
  • Fast track continuous subcutaneous insulin infusion (CSII) in young children with newly diagnosed type 1 diabetes mellitus (T1DM)
  • Implantable Antenna Sensors for Continuous Glucose Monitoring
  • Autonomy Support Psychoeducation for Parents and Middle Adolescent with Type 1 Diabetes
  • Diagnosing the Heterozygous State of Congenital Adrenal Hyperplasia Using Gas Chromatography/Mass Spectrometry Analysis of Random Urine Samples
  • Effect of incretin therapies on weight and glycemic control in children and adolescents with Type 2 Diabetes Mellitus
  • Effect of vitamin D on insulin secretion and sensitivity
  • The regulation of FGF23 by growth hormone and the latter's effect on phosphate homeostasis
  • The regulation of FGF 23 in endocrinological disorders
  • Evaluation of etiology of difficult hypertriglyceridemia
  • Lipid disorders in diabetes and obesity
  • Relationship between idiopathic bone age advancement with adrenal androgen production
  • The role of aromatase inhibitors in males with idiopathic bone age advancement
  • Current clinical therapies in cystic fibrosis related diabetes
  • Insulin sensitivity and the GH/IGF-1 axis in young children with cystic fibrosis
  • Trial Net:
    o We are an active participant in Trial Net (a study screening relatives of children with type 1 diabetes to determine if any family member is at risk for developing diabetes).
  • Growth Hormone registries:
    o The Endocrinology Division participates in post marketing surveillance and the national registries of multiple growth hormone products.
  • Exenatide in Adolescents:
    o Clinical trial examining the safety and efficacy of Exenatide in Adolescents with Type 2 Diabetes

Currently the Section has several active research projects approved by the University of Alabama Institutional Review Board. The Division avidly pursues publication of original scientific work well-respected peer-reviewed journals.