TLC Research

Research Involving Childhood Cancer Survivors
Over the past decade much has been learned about the late effects of childhood cancer therapies. This has resulted in improved screening for complications and earlier detection of any problems. Here at UAB, the TLC clinic is involved in several research opportunities to increase our knowledge of late effects. Many of the survivors are aware of these studies and some may have participated in the past. If there is a study that you would be eligible for, we may discuss the details and ask if you would like to participate.
- Childhood Cancer Survivor Study (CCSS) - This is a National Cancer Institute funded study involving over 14,000 long-term survivors of childhood cancer who were diagnosed and treated between 1970 and 1986. Much of what has been learned about late effects is due to this effort. UAB was one of 26 institutions across the United States and Canada to participate in this groundbreaking research. Efforts are currently ongoing to expand this study to include an additional 14,000 childhood cancer survivors diagnosed and treated between 1987 and 1999. We are looking forward to participating in this important project.
- Children's Oncology Group (COG) - COG is the world's largest childhood cancer research organization. Through collaboration and dedication to research, COG has treated more children with cancer than any other organization in history and has led to improvements in treatments and survival rates for childhood and adolescent malignancies. The improvements in cure rates have led to a new emphasis on late effects. COG has developed comprehensive late effects screening guidelines and has many ongoing research projects to learn more about the challenges faced by survivors.
Ongoing research studies at UAB include:
- Key adverse events after childhood cancer
- National Wilm's tumor late effects study
- Childhood Cancer Survivor Study
- TLC Database - Development, management, and analysis for late effects of childhood cancer survivors and future research protocols