Research


MingceRandy

Research in the division covers basic mechanisms of T lymphocyte function, clinical studies of temporomandibular joint arthritis and macrophage activation syndrome, and several projects aimed at optimizing the treatment of juvenile idiopathic arthritis (JIA).

Division Publications since JULY 2013
  1. Imaging of the temporomandibular joint in juvenile idiopathic arthritis. Vaid YN, Dunnavant FD, Royal SA, Beukelman T, Stoll ML, Cron RQ. Arthritis Care Res (Hoboken). 2013 Sep 19. doi: 10.1002/acr.22177. [Epub ahead of print]
  2. 2013 Update of the 2011 American College of Rheumatology Recommendations for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for the Medical Therapy of Children With Systemic Juvenile Idiopathic Arthritis and Tuberculosis Screening Among Children Receiving Biologic Medications. Ringold S, Weiss PF, Beukelman T, Dewitt EM, Ilowite NT, Kimura Y, Laxer RM, Lovell DJ, Nigrovic PA, Robinson AB, Vehe RK. Arthritis Rheum. 2013 Oct;65(10):2499-2512. doi: 10.1002/art.38092.
  3. 2013 update of the 2011 american college of rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Ringold S, Weiss PF, Beukelman T, Dewitt EM, Ilowite NT, Kimura Y, Laxer RM, Lovell DJ, Nigrovic PA, Robinson AB, Vehe RK. Arthritis Care Res (Hoboken). 2013 Oct;65(10):1551-63. doi: 10.1002/acr.22087. No abstract available.
  4. High Doses of Infliximab in the Management of Juvenile Idiopathic Arthritis. Tambralli A, Beukelman T, Weiser P, Atkinson TP, Cron RQ, Stoll ML. J Rheumatol. 2013 Oct;40(10):1749-1755. Epub 2013 Aug 15. [featured in the editorial: Prince, F.H., and Solomon, D.H. 2013. Dosing of biologics in juvenile idiopathic arthritis: is the sky the limit? J. Rheumatol. 40:1643-1645.]
  5. Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) Study. Baddley JW, Winthrop KL, Chen L, Liu L, Grijalva CG, Delzell E, Beukelman T, Patkar NM, Xie F, Saag KG, Herrinton LJ, Solomon DH, Lewis JD, Curtis JR. Ann Rheum Dis. 2013 Jul 13. doi: 10.1136/annrheumdis-2013-203407. [Epub ahead of print]
  6. Beckum KM, Kim DJ, Kelly DR, Weiser P, Lara DA, Theos A. Polyarteritis Nodosa in Childhood: Recognition of Early Dermatologic Signs May Prevent Morbidity. Pediatr Dermatol. 2013 Aug 13. doi: 10.1111/pde.12207. [Epub ahead of print]

MANUSCRIPTS IN PRESS/ACCEPTED:
  1. Stoll, M.L., and Cron, R.Q. 2013. Treatment of juvenile idiopathic arthritis in the biologic era. Rheum. Dis. Clin. North Am., in press.
  2. Rider, L.G., Shah, M., Mamyrova, G., Huber, A.M., Malley, J.D., Rice, M., Miller, F.W. with the Childhood Myositis Heterogeneity Collaborative Study Group [Cron, R.Q.]. 2013. The myositis autoantibody phenotypes of the juvenile idiopathic inflammatory myopathies. Medicine (Baltimore), in press.
  3. Shafferman, A., Fontaine, K.R., Cron, R.Q., and Beukelman, T. 2013. Changes in body mass index in children with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitors. J. Rheumatol., accepted for publication.
  4. Duverger, A., Wolschendorf, F., Anderson, J.C., Wagner, F., Bosque, A., Shishido, T., Jones, J., Planelles, V., Willey, C., Cron, R.Q., and Kutsch, O. 2013. Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation. J. Virol., accepted for publication.
  5. Lionetti G, Kimura Y, Schanberg LE, Beukelman T, Wallace C, Ilowite N, Winsor J, Fox K, Natter M, Sundy JS, Brodsky E, Curtis JR, Del Gaizo V, Iyasu S, Jahreis A, Meeker-O’Connell A, Mittleman B, Murphy B, Peterson ED, Raymond SC, Setoguchi S, Siegel J, Sobel R, Solomon D, Southwood TR, Vesely R, White P, Wulfraat N, , Sandborg CI. Using registries to identify adverse events in rheumatic diseases. Pediatrics. [accepted 26 Aug 2013]

FACULTY LECTURES SINCE JULY 2013
Weiser
  • Lecturer, “Juvenile Idiopathic Arthritis”. JA Saturdays organized by the Arthritis Foundation Alabama Chapter. March – October 2013, Hunstville, Al; Montgomery, AL; Mobile, AL
  • Lecturer, “Growing-up Pains: Is There a Cure for Adolescent Transitioning”. The 58th Annual Lowe Conference on Rheumatic Diseases. September 27-29, 2013; Stough Lodge, Camp McDowell, AL.
Cron
  • “Be Afraid, Be Very Afraid of Macrophage Activation Syndrome” - Rheumatology Medicine Grand Rounds, University of Chicago, Chicago, IL, Oct. 2013
  • “Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis: The Forgotten Joint” - AAOMS (American Association of Oral and Maxillofacial Surgeons) Annual Meeting, Orlando, FL, Oct. 2013
  • “Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis: The Forgotten Joint” - Surgery Grand Rounds, University of Alabama at Birmingham, Birmingham, AL, Oct. 2013
  • “Developing a Scoring System to Assess TMJ Arthritis by MRI in Children with JIA” - American College of Rheumatology National Scientific Meeting, San Diego, CA, Oct. 2013
Beukelman
  • “Juvenile Idiopathic Arthritis: Review and Update”. Rheumatology Nurses Society Annual Conference, Nashville, Tennessee, August 2013.
Mannion
  • “Parotitis” – Pediatric Resident Noon Conference, UAB, Birmingham, AL, October 2013
  • “Recent trends in medication usage for the treatment of juvenile idiopathic arthritis in the U.S. and the influence of TNF inhibitors”, ACR Annual Meeting, San Diego, CA, October 27, 2013
NEW DIVISIONAL GRANTS
  • Dr. Stoll to receive NIH/NIAMS P60 project grant starting in July 2013.
    $958,330 over 5 years to cover 40% salary and 5% salary for Dr. Cron.
  • Dr. Cron to begin ACR/EULAR planning grant for 1 year starting in July 2013.
    $85K over 1 year.
  • Dr. Stoll to begin ACR RRF grant funding starting in July 2013.
    $375K over 3 years.
  • Dr. Lowe to receive NRSA/NIH loan repayment program grant beginning 2013.
  • Dr. Stoll to receive Friends of CARRA pilot grant beginning in October 2013.
    $50K over 2 years.
  • Dr. Standaert to receive Michael J. Fox Foundation target validation grant beginning in October 2013.
    $250K over 2 years. (Dr. Cron collaboration)

FELLOWSHIP PROGRAM
  • 2013 site visit completed on March 13, 2013 with approval through July 2019.
  • Dr. Mannion (3rd of 3 years) currently enrolled at UAB to get her Masters of Science in Public Health degree.
  • Dr. Mannion selected and currently receiving funding from T32 [AHRQ T32 Health Services, Outcomes, and Effectiveness Research (HSOER) Training Program] through October 2014.
  • Dr. Mannion, awarded one of 10 (for entire ACR membership, pediatrics and adult) American College of Rheumatology Distinguished Fellow Award.
  • Two outstanding candidates interviewed for 2014 fellowship slot. Endowment created.

CLINICAL ACTIVITY
  • FORMED NOT-FOR-PROFIT: “Rheum4yAL” (Rheumatology for the young of Alabama, 4 sites: Birmingham, Huntsville, Mobile, Montgomery)
  • Coke Matthews met with Copeland Wood (parent) and met with Davis Pilot (Mobile). Funding provided from Wood family. Mr. Pilot agree to fund annual camp for children with rheumatic diseases indefinitely (endowed fund). Potential $100K donation to help hire Dr. Mannion at UAB if she can provide monthly clinic in Mobile (either via USA as adjunct faculty, or via private musculoskeletal clinic in Mobile).
  • Rheumatology Fact Sheet developed.
  • First UAB Pediatric Rheumatology endowed lectureship - January 9, 2014 (Dr. Carol Wallace, Seattle).
2013 Honors and Awards
Cron
  • 2013    Rud Polhill/KPRI grant recipient
  • 2013    Selected as a Top Rheumatologist in Birmingham, AL by Internat. Assoc. of Health Care Professor
  • 2013    Department of Pediatrics Excellence in Teaching Award
  • 2013    Invited Lecturer, 10th Annual Lectureship in Oral & Maxillofacial Surgery, UAB
  • 2014    American College of Rheumatology RRF/AMGEN Pediatric Rheumatology Visiting Professor
Beukelman
  • 2013    Selected Member, Society for Pediatric Research
  • 2013    ACR/EULAR International Academic Rheumatology Exchange, Early Career Investigator Delegate
Stoll
  • 2013    Selected Member, Society for Pediatric Research
Mannion (fellow)
  • 2013    Fellow-in-Training Scholarship to American College of Rheumatology State of the Art scientific meeting
  • 2013    Fellow-in-Training Scholarship to American College of Rheumatology annual scientific meeting
  • 2013    American College of Rheumatology Distinguished Fellow Award