Basic Science


CD154 Regulation and Lupus

Pediatric Rheumatology at UAB leads the way in identifying the molecular cause(s) of dysregulated CD154 expression on CD4 T lymphocytes from patients with systemic lupus erythematosus (SLE).

Selected CD154 regulation and SLE publications

CD4 T Cell Effector Function

Transcriptional control of various effector functions and cell lineage fates are explored in primary human peripheral blood CD4 T lymphocytes in the Division of Pediatric Rheumatology.

Selected transcriptional regulation of effector CD4 T cell publications

Transcriptional Regulation of HIV-1 in Host CD4 T Cells

HIV-1, the cause of AIDS, remains a worldwide problem with over 40 million infected individuals. Novel approaches at therapy based on understanding the transcriptional regulation of the virus by host CD4 T cell transcription factors are studied in the lab at UAB.

Selected HIV-1 transcriptional regulation publications