The Office of Psychiatric Clinical Research is designed to support psychiatric research in the clinical setting here at the Department of Psychiatry and Behavioral Neurobiology.  Our research division offers several cutting edge resources for Phase II, III and IV studies.  The coordination of our clinical trials is of the highest quality.  We are supported by experienced investigators and staff dedicated to academic excellence and quality patient care.  We have a full-time clinical research staff with regulatory and administrative services and assistance in designing clinical studies and providing referrals for statistical analysis.  We provide investigator training in psychiatric rating scales and standardized diagnostic instruments and education in patient recruitment.  We have a quality assurance program and facilities for drug storage, physical exams, EKG’s, interviewing, venipuncture and specimen processing. 

Our expert research team consists of:

Hollis Ryan, BS, CCRC – Clinical Trials Manager; Samantha White, BS, CCRC – Clinical Trials Administrator; Nick Bossaller, MBA – Clinical Trials Administrator; Brittanie Muse, BS – Researcher II; Katlyn Jackson, BS - Researcher II; Kristine Pike, BS, - Researcher I,; Roberta May, MA, CCRC – Associate Professor

Currently Enrolling Trials:

 Mood Disorders

" "A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Fixed-doxe Clinical Trial Evaluating the Efficacy, Safety and Tolerability of Cariprazine in Patients with Bipolar I Depression" Principal Investigator: Richard Shelton, MD

"Oxidative Stress Mechanisms in Mood Disorders" Principal Investigator: Richard Shelton, MD

"Early life origins of obesity: the relationships between early life stress and abdominal obesity in depressed patients" Principal Investigator: Li Li, MD, PhD

"A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder" Principal Investigator: Richard Shelton, MD

“Plasma Exosomal MicroRNAs as Promising Noval Biomarkers for Suicidality and Treatment Outcome" Principal Investigator: Yogesh Dwivedi, PhD, Richard Shelton, MD

“A Randomized Multicenter, Crossover Study to Assess the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Subjects With Major Depressive Disorder" Principal Investigator: Richard Shelton, MD

“Do Micro RNAs Link Diabetes with Depression and Suicide?” Principal Investigator: Richard Shelton, MD, Yogesh Dwivedi, Ph. D.

"A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus on Oral Antidepressant in Adult Subjects with treatment-resistant Depression" Principal Investigator: Richard Shelton, MD

“A Randomized, Double-blind, Multicenter, Active-controlled Study of Intranasal Esketamine Plus and Oral Antidepressant for Relapse Prevention in Treatment-resistant Depression" Principal Investigator: Richard Shelton, MD

" A Prospective, Longitudinal, Observational Study to Evaluate Potential Predictors of Relapse in Subjects With Major Depressive Disorder Who Have Responded to Antidepressant Treatment" Principal Investigator: Richard Shelton, MD

"The Role of Epigenetic Regulation of Micro RNAs on Transgenerational of Early Life Stress Effects" Principal Investigator: Richard Shelton, MD, Yogesh Dwivedi, PhD

Other Enrolling Studies

"Psychiatric Biological Samples Repository" Principal Investigator: Richard Shelton, MD

Not Currently Enrolling

" ALK5461-208: A Phase 3 Multicenter Study of the Long-term Safety and Tolerability of ALKS 5461 for the Adjunctive Treatment of Major Depressive Disorders in Adults who Have an Inadequate Response to Antidepressant Therapy (the FORWARD-2 Study)" Principal Investigator: Richard Shelton, MD

"Phase 2, Open Label Extension for Subjects with Inadequate/Partial Response to Antidepressants during the Current Episode of Major Depressive Disorder Previously Treated with GLYX13 (Extension of GLYX13-C-202, NCT0184163)" Principal Investigator: Richard Shelton, MD
 
"Cognitive Interviews of the Suicide Ideation and Behavior Assessment Tool (SIBAT) with Adolescent Subjects with a History of Suicidal Thinking" Principal Investigator: Richard Shelton, MD

"Cognitive Interview of the Suicide ideation and Behavior Assessment Tool (SIBAT) with Clinicians" Principal Investigator: Richard Shelton, MD

Healthy Volunteers

We have some studies that require Healthy Volunteers. Please contact us to find out what we have available.  

 

For further information, please contact:
UAB Department of Psychiatry
Office of Psychiatric Clinical Research
1720 7th Avenue South
Sparks Building, 10th Floor
Birmingham, AL 35294-0017
Telephone:  (205) 934-2484
Email: psychresearch@uab.edu