Department of Psychiatry
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Recent Publications

  • Tucholski J, Simmons M, Pinner AL, McMillan LD, Haroutunian V, Meador-Woodruff JH:  N-Linked Glycosylation of Cortical NMDA and Kainate Receptor Subunits in Schizophrenia.  NeuroReport. In press.
  • Calkins ME, Richard J, Edwards N, Savage RM, Allen TB, Kwentus J, McEvoy JP, Santos AB, Wiener HW, Go RCP, Perry RT, Nasrallah HA, Gur RE, Devlin B, Nimgaonkar VL: Persistent infection with neurotropic herpes viruses and cognitive Impairment.  Psychological Medicine / Volume 43 / Issue 05 / May 2013, pp 1023 1031 DOI: 10.1017/S003329171200195X, Published online: 14 September 2012
  • Fargason RE, White BA, Gamble KL. Complete Sleep-wake Cycle Reversal Related to ADHD Detected by Actigraphy. Annals of Clinical Psychiatry. April 2013. In press.
  • Rubio MD, Haroutunian V, Meador-Woodruff JH: Dysfunction of the Ubiquitin Proteasome and Ubiquitin-Like Systems in Schizophrenia. Neuropsychopharmacology. In press.
  • Gamble, K.L. and Young, M.E. (2013). Metabolism as an Integral Cog in the Mammalian Circadian Clockwork. Crit Rev Biochem Mol Biol, in press.
  • Drummond JB, Tucholski J, Haroutunian V, Meador-Woodruff JH: Transmembrane AMPA Receptor Regulatory Protein (TARP) Dysregulation in Anterior Cingulate Cortex in Schizophrenia.  Schizophrenia Research. In press.
  • Kathy B. Avsar, James E. Cox, Rosalyn E. Weller, Meredith Reid, David White, Adrienne C. Lahti. An fMRI investigation of temporal discounting in patients with schizophrenia. In Press, Brain and Behavior.
  • Mark S Bolding, David M White, Jennifer A Hadley, Martin Weiler, Henry H Holcomb, and Adrienne C Lahti. Antipsychotic drugs altered functional connectivity between medial frontal cortex, hippocampus, and ventral striatum. Frontiers in Psychiatry, 3: 105, 2012.
  • Callahan, S.T., Fuchs D.C., Shelton R.C., Balmer L.S., Dudley J.A., Gideon P.S., DeRanieri M.M., Stratton S.M, Williams C.L., Ray W.A., Cooper W.O. Identifying suicidal behavior among adolescents using administrative claims data. Pharmacoepidemiology and Drug Safety (in press).
  • Tucholski J, Simmons MS, Pinner AL, Haroutunian V, McCullumsmith RE, and Meador-Woodruff JH:  Abnormal N-linked Glycosylation of Cortical AMPA Receptor Subunits in Schizophrenia.  Schizophrenia Research. In press.
  • Nierenberg A.A., Kansky C., Brennan B.P., Shelton R.C., Perlis R., Iosifescu D.V. Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development. Australian and New Zealand Journal of Psychiatry 47:26-42, 2012.
  • Papakostas G.I., Vitolo O.V., Ishak W.W., Rapaport M.H., Zajecka J.M., Kinrys G., Mishoulon D., Lipkin S.H., Abrams J., Ward S.G., Meisner A., Schoenfeld D.A., Shelton R.C., Winokur A., Okasha M.S., Bari M.A., Fava M. A 12-week, randomized, double-blind, placebo-controlled, parallel-sequential trial of ziprasidone as monotherapy for major depressive disorder. J. Clin Psychiatry 73:1541–1547, 2012.
  • Rowse, A., L., Naves, R., Cashman, K., S., McGuire, D.J., Mbana, T., Raman, C., and De Sarno, P*., 2012. Lithium controls Central Nervous System autoimmunity through regulation of IFNγ signaling. PLoS One, 7(12): e52658. Epub 2012 Dec 28.
  • Shan D, Lucas EK,Drummond JB, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE:  Abnormal Expression of Glutamate Transporters in Temporal Lobe Areas in Elderly Patients With Schizophrenia.  Schizophrenia Research. In press.
  • Jiang Z, Rompala G, Zhang S, Cowell RM, Nakazawa K. Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons. Biological Psychiatry.  In press.
  • Papakostas GI, Shelton RC, Zajecka JM, et al. l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials. Am J Psychiatry 2012; 169:1267-1274.
  • Gamble, K.L., May, R.S., Besing, R.C., Tankersly, A.P., and Fargason, R.E. (2012). Delayed Sleep Timing and Symptoms in Adults with Attention-Deficit/Hyperactivity Disorder: A Controlled Actigraphy Study. Chronobiol Int, in press.
  • Dougherty SE, Reeves JL, Lesort M, Detloff P, Cowell RM. Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington Disease. Experimental Neurology.  In Press.
  • Fargason RE, Preston T, Hammond E, Gamble KL. Treatment of ADHD­Insomnia with Blue-Wavelength-Light Blocking Glasses. ChronoPhysiology and Therapy, November 2012. In Press.
  • JE Schumacher, C McCullumsmith, MJ Mugavero…et al.  Routine Depression Screening in an HIV Clinic Cohort Identifies Patients with Complex Psychiatric Co-morbidities Who Show Significant Response to Treatment.  AIDS and Behavior, 2012
  • Kerman, I.A., Bernard,R,Bunney, W.E., Jones, E.G., Schatzberg, A.F., Myers, R.M., Barchas, J.D., Akil, H., Watson, S.J., Thompson, R.C. Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder. Frontiers in Neurogenomics in press.
  • Mark S. Bolding, Adrienne C. Lahti, Timothy J. Gawne, Kristine B. Hopkins, Demet Gurler, Paul D. Gamlin. Ocular convergence deficits in schizophrenia. Frontiers in Schizophrenia, In Press.
  • Drummond JB, Simmons M, Haroutunian V, Meador-Woodruff JH: Upregulation of Cornichon Transcripts in Dorsolateral Prefrontal Cortex in Schizophrenia. NeuroReport. In press.
  • Rachel Fargason, Samantha White, Abigal Hernandez, Karen Gamble. Adults with Attention-deficit Hyperactivity Disorder without Insomnia History have Subclinical Sleep Disturbance but not Circadian Delay: an ADHD Phenotype? In Press. Journal of Attention Disorders.
  • Paul, J.R., Johnson, R.L., Jope, R.S., and Gamble, K.L. (2012). Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase-3. Neuroscience, in press.
  • Kerman, I. A. New insights into BDNF signaling: relevance to major depression and antidepressant action. American Journal of Psychiatry. In press.
  • Gibson SA, Korade Z, Shelton RC. Oxidative stress and glutathione response in tissue cultures from persons with major depression. Journal of Psychiatric Research 2012; 46:1326-1332.
  • Eid T, Lee TW, Wang Y, Perez E, Drummond J, Lauritzen F, Bergersen LH, Meador-Woodruff JH, Spencer DD, de Lanerolle ND, McCullumsmith RE: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy. Epilepsia. In press.
  • Mark S Bolding, Meredith A Reid, Kathy B Avsar, Timothy J Gawne, Paul Gamlin, Rosalinda C Roberts, Jan A den Hollander, Adrienne C Lahti. Magnetization transfer contrast (MTC) MRI accurately localizes substantia nigra as confirmed by histology. In Press. Biological Psychiatry.
  • Funk AJ, McCullumsmith RE, Haroutunian V, and Meador-Woodruff JH: Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia. Neuropsychopharmacology. 37: 896-905, 2012.
  • Rubio MD, Drummond JB, and Meador-Woodruff JH: Glutamate Receptor Abnormalities in Schizophrenia: Implications for Innovative Treatments. Biomolecules and Therapeutics. 20: 1-18, 2012.
  • Rubio MD, Haroutunian V, and Meador-Woodruff JH: Abnormalities of the Duo/Ras-Related C3 Botulinum Toxin Substrate/p21-Activated Kinase 1 Pathway Drive Myosin Light Chain Phosphorylation in Frontal Cortex in Schizophrenia. Biological Psychiatry. 71: 906-914, 2012.
  • Savage RM, Weiner HW, Nimgaonkar V, Devlin B, Calkins ME, Gur RE, O’Jile J, Bradford LD, Edwards N, Kwentus J, McEvoy JP, Nasrallah H, Santos AB, Aduroja T, Allen T, Lahti A, May RS, Montgomery-Barefield L, Go RCP: Heritability of Functioning in Families with Schizophrenia in Relation to Neurocognition, Schizophrenia Research, E-published: 23 May 2012.
  • Sestero, C. M., McGuire, D.J., De Sarno, P. , Brantley, E. C., Soldevila, G., Axtell, R. C., and Raman, C., 2012. CD5-dependent CK2 activation pathway regulates threshold for T-cell anergy. J. Immunol., In Press.
  • Zhou, W., Chen, L., Paul, J.R., Yang, S., Li F., Sampson, K., Woodgett, J.R., Beaulieu, J.M., Gamble, K.L. , and Li, X. (2012). The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons. PloS ONE, in press.
  • Elizabeth K. Lucas, Sarah E. Dougherty, Laura J. McMeekin, Alisa T. Trinh, Courtney S. Reid, & Rita M. Cowell.Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1a. PLoS ONE, in press.
  • Shelton R.C. Does concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDS) reduce the effectiveness of antidepressants? Am J Psychiatry (in press).
  • Bray, M.S., Ratcliffe, W.F., Grenett, M.H., Brewer, R.A., Gamble, K.L. , and Young, M.E. (2012). Quantitative Analysis of Light-Phase Restricted Feeding Reveals Metabolic Dyssynchrony in Mice. Int J Obesity, in press.
  • Nina K Kraguljac, Meredith M Reid, David M White, Jen A den Hollander, Adrienne C Lahti. Regional Decoupling of N-Acetyl-Aspartate and Glutamate in Schizophrenia. In Press. Neuropsychopharmacology
  • Nathan Hutcheson, Meredith A Reid, David M White, Nina V. Kraguljac, Kahty B Avsar, Mark S Bolding, Robert C Knowlton, Jan A Den Hollander, Adrienne C Lahti. Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging. In Press. Schizophrenia Research.
  • Hammond JC, Meador-Woodruff JH, Haroutunian V, McCullumsmith RE (2012) Ampa Receptor Subunit Expression in the Endoplasmic Reticulum in Frontal Cortex of Elderly Patients with Schizophrenia. PLoS ONE 7(6): e39190. doi:10.1371/journal.pone.0039190
  • Ashish Kumar, Andrew Kneynsberg, Janusz Tucholski; Giselle Perry, Thomas van Groen, Peter J Detloff, Mathieu Lesort: Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington’s disease. Experimental Neurology, in press.
  • Ruan, G., Gamble, K.L. , Risner, M., Young, L., and McMahon, D.G. (2012). Divergent Roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators. PLoS ONE, in press.
  • Jackson, C.R., Ruan, G., Aseem, F., Abey, J., Gamble, K.L. , Stanwood, G., Palmiter, R.D., Iuvone, P.M., and McMahon, D.G. (2012). Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci, in press.
  • DeAndrade, M.P., Johnson Jr., R.L., Unger, E.L., Zhang, L., van Groen, T., Gamble, K.L. , and Li,Y. (2012). Motor restlessness, sleep disturbances, thermal sensory alterations, and elevated serum iron levels in Btbd9 mutant mice. Hum Mol Gen, in press.
  • Hammond JV, Meador-Woodruff JH, Haroutunian V, and McCullumsmith RE: AMPA Receptor Subunit Expression in the Endoplasmic Reticulum in Frontal Cortex of Elderly Patients With Schizophrenia. PLoS ONE. In press.
  • Ruan, G., Gamble, K.L. , Risner, M., Young, L., and McMahon, D.G. (2012). Divergent Roles of Clock Genes in Retinal and Suprachiasmatic Nucleus Circadian Oscillators. PLoS ONE, accepted.
  • Sarah E. Dougherty, Jennifer L. Reeves, Elizabeth K. Lucas, Karen L. Gamble, Mathieu Lesort, and Rita M. Cowell. Disruption of Purkinje Cell Function Prior to huntingtin accumulation and cell loss in an animal model of Huntingtin Disease. Experimental Neurology. In press.
  • Melendez-Ferro M, Rice MW, Roberts RC, and Perez-Costas E. Dual use of immunohistochemistry for film densitometry and light microscopy. Journal of Neuroscience Methods (2012) IN PRESS
  • Buck, B. J., Nolen, L. K., Koch, L. G., Britton, S. L., Kerman, I. A. Alterations in the brainstem preautonomic circuitry may contribute to hypertension associated with metabolic syndrome. Cardiovascular Risk Factors, Ed.: Gasparyan, A. Y., InTech, http://www.intechopen.com/books/cardiovascular-risk-factors/alterations-in-baro-sensitive-circuitry-within-the-brainstem-may-contribute-to-hypertension-in-indiv
  • Qin, H., Yeh, W-I, De Sarno, P. , Muldowney, M., Reynolds, S., Holdbrooks, A., Yanagisawa, L., Harrington, L., Raman, C and Benveniste, E., 2012. The STAT3/SOCS3 Axis in Myeloid Cells Regulates Neuroinflammation. Proceedings of National Academy of Sciences USA 109(13): 5004-9.
  • Howard Wiener, Lambertus Klei, Monica Calkins, Joel Wood, Vishwajit Nimgaonkar, Ruben Gur, L. DiAnne Bradford, Jan Richard, Neil Edwards, Robert Savage, Joseph Kwentus, Trina Allen, Joseph McEvoy, Alberto Santos, Raquel Gur, Bernie Devlin, and Rodney Go: Principal Components of Heritability From Neurocognitive Domains Differ Between Families With Schizophrenia and Control Subjects. Schizophrenia Bulletin DOI: 10:1093/schbul/shr 161
  • Emma Perez-Costas, Miguel Melendez-Ferro, Matthew W Rice, Robert R Conley, Rosalinda C Roberts. “Dopamine pathology in schizophrenia: Analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra.” Frontiers in Schizophrenia. In press
  • McCullumsmith, C, Clark, CB, Perkins, A, Fife, J., Cropsey, K. “Gender and Racial Differences for Suicide Attempters and Ideators in a High Risk Community Corrections Population.” Crisis: The Journal of Crisis Intervention and Suicide Prevention. In Press
  • Robert M. Savage • Jacqueline M. Dillon • Jacinda C. Hammel • Tonia C. Lewis • Natasha C. Johnson • Lafon M. Barlow • Molly M. Brooms • Patricia M. Moore • Henry E. Parker • Kanini Z. Rodney. The Alabama Coalition for a Healthier Black Belt: A Proof of Concept Project. Community Ment Health J. DOI 10.1007/s10597-012-9488-z
  • Kraguljac N V, Reid M A, White D M, Jones R, den Hollander J, Lowman D K, Lahti A C. Neurometabolites in schizophrenia and bipolar disorder-a systematic review and meta-analysis. Psychiatry Research: Neuroimaging. In Press.
  • Rubio MD, Haroutunian V, and Meador-Woodruff JH: Abnormalities of the Duo/Rac-1/PAK1 Pathway Drive Myosin Light Chain Phosphorylation in Frontal Cortex in Schizophrenia. Biological Psychiatry. In press.
  • Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. (2012) LRRK2 inhibition attenuates microglial inflammatory responses. J. Neurosci. 32:1602-11.
  • Thurstin, A. (in press). Beyond rose colored glasses: the adaptive role of depressive and anxious symptoms among individuals with heart failure who were evaluated for transplantation. Clinical Transplantation.
  • Moehle, M.S., Luduena, R.F., Haroutunian, V., Meador-Woodruff, J.H., and McCullumsmith, R.E. Regional Differences in Expression of β-Tubulin Isoforms in Schizophrenia. Schizophrenia Research, in press, 2011.
  • Shan, D., Haroutunian, V., Meador-Woodruff, J.H., and McCullumsmith, R.E. Expression of ENT1 Protein in Elderly Patients with Schizophrenia. NeuroReport, in press, 2011.
  • Besing, R.C., Hablitz, L.M., Paul, J.R., Johnson, R.L., Prosser, R.A., and Gamble, K.L. NPY-Induced Phase Shifts of PER2::LUC Rhythms Are Mediated by Long-Term Suppression of Neuronal Excitability in a Phase-Specific Manner. Chronobiology International, in press, 2011.
  • Rubio, M.D., Drummond, J.B., and Meador-Woodruff, J.H. Glutamate Receptor Abnormalities in Schizophrenia: Implications for Innovative Treatments. Biomolecules and Therapeutics, in press, 2011.
  • McCollum, L.A., Roche, J.K., and Roberts, R.C. Immunohistochemical Localization of Enkephalin in the Human Striatum: A Postmortem Ultrastructural Study. Synapse, Published Online Oct 27, 2011. PMID: 22034050 [PubMed]
  • Fargason, R.E., Gamble, K.L., Avis, K.T., Besing, R.C., Jackson, C., Cates, M., and May, R.S. Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD). Psychopharm Bull, in press, 2011.
  • Durgan, D.J., Pat, B.M., Laczy, B., Bradley, J.A., Tsai, J., Grenett, M.H., Ratcliffe,W.F., Brewer, R.A., Nagendran, J., Villegas-Montoya, C., Zou, C., Johnson, R.L., Dyck, J.R.B., Bray, M.S., Gamble, K.L., Chatham, J.C., and Young, M.E. O-GlcNAcylation: A Novel Post-Translational Modification Linking Myocardial Metabolism and the Cardiomyocyte Circadian Clock. Journal of Biol Chem, E-pub ahead of print, Nov 8, 2011. PMID: 22069332 [PubMed]