Sylvia LG, Friedman ES, Kocsis JH, Bernstein EE, Brody BD, Kinrys G, Kemp DE, Shelton RC, McElroy SL, Bobo WV, Kamali M, McInnis MG, Tohen M, Bowden CL, Ketter TA, Deckersbach T, Calabrese JR, Thase ME, Reilly-Harrington NA, Singh V, Rabideau DJ, Nierenberg AA. Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder. Journal of Affective Disorders (in press).

Dr. Shelton was one of the principle investigators in a large-scale clinical trial comparing the effectiveness of lithium carbonate and quetiapine for the treatment of bipolar disorder supported by the U.S. Agency for Healthcare Research and Quality. This analysis shows that there is a mood-specific relationship between exercise frequency and mood state such that depression is associated with less exercise and mania with more exercise in individuals with bipolar disorder.

Exercise and other health interventions such as diet represent emerging approaches for adjunctive management of people with major mental illnesses. This paper reviews the possible effects of exercise on outcomes in bipolar patients.

Data such as reported in this paper may help to expand the treatment repertoire of Psychiatrists to include lifestyle interventions to help their patients.