Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia.Ren X, Rizavi HS, Khan MA, Bhaumik R, Dwivedi Y, Pandey GN. Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia. J Affect Disord. 2014 Jan;152-154:326-33.
cyclic-AMP (cAMP) response element binding protein (CREB) is a transcription factor that regulates the expression of critical genes involved in neuronal functions. The present study examined whether CREB is modulated in bipolar disorder and schizophrenia, since expression of CREB-mediated genes have been shown to be altered in these disorders. Our study shows that not only expression of CREB is lower but functional characteristics of this transcription factor are altered in brain of subjects with bipolar disorder and schizophrenia in a brain-region specific manner.
Our study is important suggesting that abnormalities in CREB could be associated with alterations in gene expression, a key feature of bipolar disorder and schizophrenia, and that agents acting at the level of CREB may be useful in the treatment.