Jessy Deshane, PhD
|Assistant Professor of Medicine
Division of Pulmonary, Allergy
& Critical Care Medicine
1720 2nd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294
|Campus Address:||THT 422|
|Academic Office Location:||THT 433|
|Office Phone:||(205) 996-2041|
|Office Fax:||(205) 934-1721|
Jessy Deshane received her PhD in Biochemistry and Molecular Genetics from University of Alabama at Birmingham under the mentorship of Dr. Anupam Agarwal. After completing her post-doctoral training in Immunology with Dr. David Chaplin, in Department of Microbiology, she joined the faculty of the Division of Pulmonary Allergy and Critical Care Medicine in the Department of Medicine in 2011 as an Assistant Professor.
Academic & Research Interests
Dr. Deshane is committed to an academic career combining basic and translational research with an emphasis on inflammatory diseases of the airway. The focus of Dr. Deshane's research program is to enhance our understanding of the role of myeloid-derived regulatory cells in chronic airway inflammatory diseases. Asthma is a chronic inflammatory disease of the airways in which innate and adaptive immune cells participate as drivers of the inflammatory response. Free radical species have long been implicated as critical mediators of the asthmatic inflammatory process. Dr. Deshane's studies in a mouse model of allergic airway inflammation have established that subsets of free radical-producing myeloid-derived regulatory cells (MDRC) are master regulators of airway inflammation. They are potent modulators of both T cell responses and airway hyper-responsiveness. Dr. Deshane has identified human MDRC with similar function in bronchoalveolar lavage of asthmatics. Her current research interests are (1) to explore the free radical and cytokine/chemokine mediated mechanisms underlying the differentiation and function of myeloid derived regulatory cells in the establishment of airway inflammation and resolution of inflammation (2) to investigate MDRC- mediated regulation of the balance of Tregulatory cells and Th17 cells which control the tolerance vs inflammation (3) to understand how environmental pollutants such as tobacco smoke would impact MDRC function and contribute to exacerbation of inflammation in asthmatic smokers. These studies will provide insight into the role of MDRC in tobacco related pathology of the lung.