deshane website photo Assistant Professor of Medicine

Division of Pulmonary, Allergy 
& Critical Care Medicine
1720 2nd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294
Contact Information
Campus Address: THT 422
Academic Office Location: THT 433A
Office Phone: (205) 996-2041
Office Fax: (205) 934-1721
Email Address: treena@uab.edu

Graduate School:
University of Alabama at Birmingham, Birmingham, AL

Postdoctoral Training:
University of Alabama at Birmingham, Birmingham, AL

Brief Bio

Jessy Deshane received her PhD in Biochemistry and Molecular Genetics from University of Alabama at Birmingham under the mentorship of Dr. Anupam Agarwal. After completing her post-doctoral training in Immunology with Dr. David Chaplin, in Department of Microbiology, she joined the faculty of the Division of Pulmonary, Allergy, and Critical Care Medicine in the Department of Medicine in 2011 as an Assistant Professor.

Academic & Research Interests  
Dr. Deshane is committed to an academic career combining basic and translational research with an emphasis on inflammatory diseases of the airway. She has a strong research interest in myeloid-derived regulatory cells (MDRCs) and their immunoregulatory reoles in chronic inflammatory lung diseases. Asthma is a chronic inflammatory disease of the airways in which innate and adaptive immune cells participate as drivers of the inflammatory response. Free radical species have long been implicated as critical mediators of the asthmatic inflammatory process.  Dr. Deshane's studies in a mouse model of allergic airway inflammation have established that subsets of free radical-producing myeloid-derived regulatory cells (MDRC) are master regulators of airway inflammation. They are potent modulators of both T cell responses and airway hyper-responsiveness.  Dr. Deshane has identified human MDRC with similar function in bronchoalveolar lavage of asthmatics.

Her current research interests are to explore the free radical and cytokine/chemokine mediated mechanisms underlying the differentiation and function of myeloid derived regulatory cells in the establishment of airway inflammation and resolution of inflammation ,to investigate MDRC- mediated regulation of the balance of Tregulatory cells and Th17 cells which control the tolerance vs inflammation, and to understand how environmental pollutants such as tobacco smoke would impact MDRC function and contribute to exacerbation of inflammation in asthmatic smokers. These studies will provide insight into the role of MDRC in tobacco related pathology of the lung.

Key Publications
Walker MM, Novak L, Widener R, Grubbs JA, King J, Hale JY, Ochs MM, Myers LE, Briles DE, Deshane J. PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia. J Immunol. 2016 Feb 1. pii: 1402518. [Epub ahead of print] PubMed PMID: 26829988. PMCID in progress

Liu RM, Eldridge S, Watanabe N, Deshane JS, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert LM, Miyata T, Thannickal VJ. Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 23:ajplung.00217.2015. doi: 10.1152/ajplung.00217.2015. [Epub ahead of print]. PubMed PMID: 26702150. PMCID in progress.

Liu Z, Bone N, Jiang S, Park DW, Tadie JM, Deshane J, Rodriguez CA, Pittet JF, Abraham E, Zmijewski JW. AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury. Molecular Medicine. 2015 Mol Med. 2015 Nov 30. doi: 10.2119/ molmed.2015. 00198. [Epub ahead of print]. PubMed PMID: 26650187 PMCID in progress.

Yu H, Liu Y, McFarland BC, Deshane JS, Hurst DR, Ponnazhagan S, Benveniste EN, Qin H. SOCS3 Deficiency in Myeloid Cells promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells. Cancer Immunol Res. 2015 Feb; pii: canimm.0004.2015. [Epub ahead of print]. PubMed PMID: 25649351 PMCID in progress.

*Deshane JS, Redden DT, Zeng M, Spell MT, Zmijewski JW, Anderson JT, Deshane RJ, Gaggar A, Siegal GP, Abraham EA, Dransfield MT, DD Chaplin. Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease. J. Allergy and Clinical Immunology. 2015 Feb;135(2):413-424.e15 doi: 10.1016/j.jaci.2014. PubMed PMID: 25420684 PMCID: PMC 4323991 (Available on 2016-02-01).

Wang Y, Jin TH, Farhana A, Freeman J, Estell K, Zmijewski JW, Gaggar A, Thannickal V, Schwiebert L, Steyn AJC, Deshane JS. Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness. Laboratory Investigation. 2014 Dec;94(12):1312-1325. doi:10.1038/labinvest.2014.126. PubMed PMID:25365203 PMCID: PMC 4245361(Available on 2015/6/1).

Trevor JL & Deshane JS. Refractory Asthma: mechanisms, targets and therapy. Allergy 2014   Jul ;69(7):817-27, doi: 10.1111/all.12412. PubMed PMID: 24773466 PMCID: PMC 4279947.

Sawant A, Schafer CC, Jin TH, Zmijewski J, Tse HM, Roth J, Sun Z, Siegal GP, Thannickal VJ, Grant SC, Ponnazhagan S, Deshane J. Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways. Cancer Res 2013 Nov 15;73:6609-20. doi: 10.1158/0008-5472. PubMed PMID: 24085788 PMCID:PMC3854493.

Sawant A, Deshane J, Jules J, Lee CM, Harris BA, Feng X, Ponnazhagan S. Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. Cancer Res. 2013 Jan 15;73(2):672-82. doi: 10.1158/0008-5472.CAN-12-2202. Epub 2012 Dec 14. PubMed PMID: 23243021; PubMed Central PMCID: PMC3548966.

Sawant A, Schafer CC, Ponnazhagan S, Deshane J. The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer. Oncoimmunology 2014 Jan 1;3(1):e27401,doi:10.4161/onci.27401. PubMed PMID: 24711958 PMCID: PMC 3976979.

Jiang S, Park DW, Tadie JM, Gregoire M, Deshane J, Pittet JF, Abraham E, Zmijewski JW. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014 May 15;192(10):4795-803. doi: 10.4049/jimmunol.1302764. PubMed PMID: 24719460 PMCID: PMC4018664.

Bae HB, Zmijewski JW, Deshane JS, Zhi D, Thompson LC, Peterson CB, Chaplin DD, Abraham E. Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways. Am J Respir Cell Mol Biol. 2012 Jun;46(6):790-6. doi: 10.1165/rcmb.2011-0187OC. Epub 2012 Jan 26. PubMed PMID: 22281987; PubMed Central PMCID: PMC3380283.

Tadie JM, Bae HB, Deshane JS, Bell CP, Lazarowski ER, Chaplin DD, Thannickal VJ, Abraham E, Zmijewski JW. Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med. 2012 May 9;18:659-68. doi: 10.2119/molmed.2011.00401. PubMed PMID: 22396017; PubMed Central PMCID: PMC3388138.

Deshane J, Zmijewski JW, Luther R, Gaggar A, Deshane R, Lai JF, Xu X, Spell M, Estell K, Weaver CT, Abraham E, Schwiebert LM, Chaplin DD. Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness. Mucosal Immunol. 2011 Sep;4(5):503-18. doi: 10.1038/mi.2011.16. Epub 2011 Apr 6. PubMed PMID: 21471960; PubMed Central PMCID: PMC3694614.

Bae HB, Zmijewski JW, Deshane JS, Tadie JM, Chaplin DD, Takashima S, Abraham E. AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J. 2011 Dec;25(12):4358-68. doi: 10.1096/fj.11-190587. Epub 2011 Sep 1. PubMed PMID: 21885655; PubMed Central PMCID: PMC3236633.

Please click here for Dr. Deshane's complete publications listing.

SOM Epilogue Menu