Proteins and Peptides in Biological/Clinical Samples
Dr. Patricia Jackson completed her undergraduate education in chemistry, graduating Summa Cum Laude at Cumberland College. Later, she continued her graduate training at Purdue University,working on high field NMR and structural biology in the laboratories of Dr. David Gorenstein. In 1993, she came to UAB as a postdoctoral fellow in the Comprehensive Cancer Center NMR Core Facility, then moved to the UAB Department of Chemistry where she taught organic chemistry and did biophysical-based research until 2000. She then joined the laboratory of Dr. Ed Blalock in the Department of Physiology and Biophysics. In 2009 she moved with Dr. Blalock to the Division of Pulmonary, Allergy & Critical Care Medicine and was promoted to the rank of Assistant Professor of Medicine.
Dr. Jackson's lab is interested the study of proteins and peptides present in biological/clinical samples from diseases involving a heavy neutrophilic inflammation component such as COPD, CF and influenza. To this end, the lab is pursuing new techniques for the detection and quantitation of peptides in these samples specifically using ESI-MS-MS. The lab also seeks to understand the structure, binding and mechanism of action of these peptides and proteins using NMR techniques such as trNOESY. This knowledge of structure activity relationship is then applied in the design of novel agonists and antagonists. The lab is currently focused on the collagen breakdown products such as the chemoattractant peptide PGP, the enzymes involved in its production and degradation as well as its binding to the chemokine receptors CXCR1/CXCR2.
Education & Training
Perdue University, West Lafayette, IN
University of Alabama at Birmingham, Birmingham, AL