Tracy Luckhardt, MD

Pulm_Div_Luckhardt

 

 

Assistant Professor of Medicine

Associate Director, UAB Pulmonary and Critical Care Fellowship Program

Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294

 

Board Certifications
2003, American Board of Internal Medicine
2006, American Board of Internal Medicine, Pulmonary Diseases
2007, American Board of Internal Medicine, Critical Care Medicine

Medical School:  Louisiana State University Health Sciences Center, Shreveport, LA, 1996-2000

Internship & Residency:  University of Iowa Hospitals and Clinics, Iowa City, IA, 2000 - 2003

Chief Medical Resident:  University of Iowa Hospitals and Clinics, Iowa city, IA 2003-2004 

Fellowship:  University of Michigan Hospitals and Health Centers, Ann Arbor, MI, 2004-2007

Masters:  Masters in Clinical Research Design and Statistical Analysis, School of Public Health,
University of Michigan Hospitals and Health Centers, Ann Arbor, MI, 2007-2009

Contact Information

   

Campus Address:

 

 THT 433-A

Academic Office location:

 

 THT 433-A

Office Phone:

 

 (205) 934-1283

Office Fax (Academic):

 

 (205) 934-1721

TKC Clinic Phone:

 

 (205) 801-7545

TKC Clinic Fax:

 

 (205) 802-8231

Email Address:

 

 tluck@uab.edu

Beeper #:

 

 7482

Office Assistant:   

Jessica Hargrove
Phone: (205) 996-9405
Fax: (205) 934-1721

Brief Bio

Dr. Luckhardt completed her medical training in May 2000 from the Louisiana State University Health Sciences Center in Shreveport, Louisiana, where she graduated Alpha Omega Alpha.  She completed her Internal Medicine training at the University of Iowa Hospitals and Clinics in 2003.  She was Chief Resident of Internal Medicine at the University of Iowa from 2003-2004.  She then completed her Pulmonary and Critical Care Training at the University of Michigan.  She was appointed as faculty there from 2007 until 2009 when she joined the faculty at UAB.  Dr. Luckhardt has also completed a Masters program at the University of Michigan in 2009 in Clinical Research Design and Biostatistics.  She has served on the American Thoracic Society Training committee, and on the University of Michigan's Pulmonary Fellow's Education committee.

 

Clinical Interests 

Dr. Luckhardt has particular interests in evaluating and treating patients with interstitial lung disease.  She is interested in trying to understand what populations are at risk and how to detect markers that will lead to the progression of these diseases.  She is also interested in conducting studies that will hopefully lead to new treatments for these patients.

Academic & Research Interests

To complement her clinical interest in interstitial lung disease, Dr. Luckhardt has undertaken basic and translational investigations into the pathogenesis of idiopathic pulmonary fibrosis.  In particular, she is interested in the role of herpesviral infections in either the development or progression of pulmonary fibrosis.  She has been able to demonstrate in a mouse model of fibrosis, that a gammaherpesvirus infection can exacerbate established pulmonary fibrosis.  This is likely due to an increase in CCL12 production and recruitment of fibrocytes to the lungs.  She has also demonstrated that TLR9 is important in limiting viral infection in the mouse and preventing viral-induced alveolar epithelial cell injury.  She is currently working on understanding how TLR9 regulates the response of the alveolar epithelial cell to viral infection, and whether or not alterations in TLR9 signaling might be important in the alveolar epithelium of IPF patients.  She also has interest in understanding whether or not a viral infection can influence the fate and plasticity of type II alveolar epithelial cells, and whether or not aging changes the cell's response to viral infection.

Key Publications

1. McMillan TR, Weinberg JB, Vannella KM, Christensen PJ, Fields, WB, van Dyk LF, Toews GB and Moore BB. Exacerbation of Established Pulmonary Fibrosis in a Murine Model by Gammaherpesvirus. Am J Respir Crit Care Med. 2008; 177(7): 771-80.

2. Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S, Martinez FJ, Thannickal VJ. NADPH Oxidase-4 Mediates Myofibroblast Activation and Fibrogenic Responses to Lung Injury. Nature Medicine.

3. Luckhardt TR, Bhan U, Stoolman JS, Vannella DV, Coomes SM, Wilke CA, Standiford TJ, Moore BB, Toews GB. TLR9 Signaling Protects from Gammaherpesvirus-Induced Pulmonary Fibrosis by Limiting Alveolar Epithelial Cell Apoptosis. J Immunol. 2009 (in revision)

4. Vannella KV, Luckhardt TR, Wilke CA, van Dyke LF, Toews GB, Moore BB. Latent Herpesvirus Infection Augments Experimental Pulmonary Fibrosis. Am J Respir Crit Care Med. 2009 (in revision).

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